Effect of embryo glue transfer medium during fresh and frozen-thawed embryo transfer

Tomari, Hiroyuki; Honjou, K.; Kunitake, K.; Nishimura, K.; Hidaka, Naomi; Nagata, Y.

doi:10.1016/j.fertnstert.2014.07.1062

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meta-analyses of Japanese studies involving nearly 10,000 cycles show increased implantation and pregnancy rates from fresh and cryo transfers, after the use of EG medium. 12,13 Their results confirm the previous conclusions of the Cochrane report. HA-enriched media may increase the implantation rate 14 and clinical pregnancies in patients with previous failed implants and in the third or more attempts after cryo ET.…”

Section: Discussionsupporting

confidence: 88%

“…10,15 They also report that clinical pregnancies and implantation rates were higher in embryos after cryo ET, indicating that the viscosity of the EG medium physically protects embryos after assisted hatching. 13 Zhang et al 16 and Wu et al 17 investigated whether EG has an impact on pregnancy outcome during in vitro fertilisation compared to G2 medium. In conclusion, they cite EG as a transfer medium that can improve the rate of implantation and pregnancy in the IVF program.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Pavlović-Vasić¹,

Sibinčić²,

Milaković³

et al. 2021

Scripta Medica

View full text Add to dashboard Cite

Introduction: Thanks to ever-growing advances in medical science, couples who are in the in vitro fertilisation (IVF) now have more options than ever to encase their chances at a successful pregnancy. One of the options is the use of EmbryoGlue (EG), that creates a bridge between the embryo and the uterus and provides protection to the embryo itself during the transfer process. Aim of this study was to determine whether EG medium is of greater importance for embryo implantation than conventional medium in assisted reproductive technology and compare the rate of embryo implantation with EG and conventional medium in relation to the quality of the embryo, the age of the patients and tobacco smoking. Methods: The retrospective study included 50 patients who used EG medium in embryo transfer (ET) and 50 patients in the control group using conventional medium. All patients underwent ET after stimulation of the cycle according to a short protocol. ETs were done on Day 2, 3, or 5 in the blastocyst stage. Age and smoking status were recorded. Results: Out of a total of 100 patients, 42 patients had successful implantation and positive b-hCG 15 days after ET. In a control group 38 % had positive b-hCG and in the group of patients who used EG 46 %. A higher rate of embryo implantation success was observed on the second day of transfer in the group of patients using EG. In the EG group a significant increase in the embryo implantation rate was observed in patients older than 35. In tobacco smokers the implantation rate was higher if they used EG during ET. Conclusion: EG medium had a positive effect on the second day of ET, patients above the age of 35 and patients who were tobacco smokers.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Pavlović-Vasić¹,

Sibinčić²,

Milaković³

et al. 2021

Scripta Medica

View full text Add to dashboard Cite

show abstract

Hyaluronic acid in embryo transfer media for assisted reproductive technologies

Heymann

Vidal²,

et al. 2020

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

STUDY QUESTION Does the addition of hyaluronic acid (HA) to embryo transfer medium improve pregnancy outcomes in both autologous and oocyte donation IVF cycles? SUMMARY ANSWER The best available evidence indicates that the addition of HA to embryo transfer medium is clinically beneficial in cycles with autologous oocytes. WHAT IS KNOWN ALREADY There is a known clinical benefit of HA addition to embryo transfer media but it is not known if HA affects donor and autologous oocyte cycles differently. STUDY DESIGN, SIZE, DURATION A systematic review with meta-analysis was performed. The Cochrane Gynaecology and Fertility Group Trials Register, CENTRAL via Cochrane Register of Studies Online (CRSO), MEDLINE, Embase and PsycINFO electronic databases (until 8 January 2020) were searched for randomized controlled trials (RCTs) examining the effect of HA in embryo transfer medium on pregnancy outcomes. PARTICIPANTS/MATERIALS, SETTING, METHODS RCTs with separate donor and autologous oocyte data that compared embryo transfer medium with functional HA concentrations (0.5 mg/ml) to those containing no or low HA concentrations (0.125 mg/ml) were included. Two review authors independently selected trials for inclusion, extracted data and assessed the included studies using the Cochrane risk of bias assessment tool. Pooled risk ratios and 95% CIs were calculated. A summary of findings table was generated using Grading of Recommendations, Assessment, Development and Evaluation criteria. Judgements about evidence quality were justified and incorporated into the reported results for each outcome. MAIN RESULTS AND THE ROLE OF CHANCE Fifteen studies, totalling 4686 participants, were analysed. In autologous oocyte cycles, live birth increased from 32% to 39% when embryo transfer media contained functional HA concentrations (risk ratio (RR) 1.22, 95% CI 1.11–1.34; nine studies, 3215 participants, I2 = 39%, moderate-quality evidence (number needed to treat (NNT) 14). HA-enriched media increased clinical pregnancy and multiple pregnancy rates by 5% and 8%, respectively (RR 1.11, 95% CI 1.04–1.18; 13 studies, 4014 participants, I2 = 0%, moderate-quality evidence, NNT 21) and (RR 1.49, 95% CI 1.27–1.76; 5 studies, 2400 participants, I2 = 21%, moderate-quality evidence, number needed to harm 13). Conversely, in donor oocyte cycles, HA addition showed little effect on live birth and clinical pregnancy (RR 1.12 95% CI 0.86–1.44; two studies, 317 participants, I2 = 50%, low-quality evidence) and (RR 1.06, 95% CI 0.97–1.28; three studies, 351 participants, I2 = 23%, low-quality evidence). There was insufficient available information on multiple pregnancy in donor oocyte cycles and on total adverse effects in both groups to draw conclusions. LIMITATIONS, REASONS FOR CAUTION There were limited studies with separate data on donor oocyte cycles and limited information on oocyte quality. Additionally, one-third of the included studies did not include the main outcome, live birth rate. WIDER IMPLICATIONS OF THE FINDINGS There is a moderate level of evidence to suggest that functional HA concentration in embryo transfer medium increases clinical pregnancy, live birth and multiple pregnancy rates in IVF cycles using autologous oocytes. This effect was not seen in donor oocyte cycles, indicating either intrinsic differences between donor and autologous oocytes or lack of statistical power. The combination of HA addition to transfer media in cycles using autologous oocytes and a single embryo transfer policy might yield the best combination, with higher clinical pregnancy and live birth rates without increasing the chance of multiple pregnancies. STUDY FUNDING/COMPETING INTEREST(S) No financial assistance was received. The authors have no competing interests. REGISTRATION NUMBER N/A.

show abstract

Effect of embryo glue transfer medium during fresh and frozen-thawed embryo transfer

Cited by 4 publications

References 0 publications

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Hyaluronic acid in embryo transfer media for assisted reproductive technologies

The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis

Contact Info

Product

Resources

About