Effect of Embryo Fragment Removal of Day 3 Embryos in Recurrent Implantation Failure

Gürgan, Timur; Sarı, Tamer; BenKhalifa, Mustapha

doi:10.1016/j.fertnstert.2005.07.738

Cited by 1 publication

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“…This fragmentation could represent an effort of the embryos to discard defective blastomeres that could impede correct embryo development ( 7 ). Other theories involve cell apoptosis and chromosome abnormalities ( 6 ); however, no consensus exists to explain the origin of the fragments found in developing embryos.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Pregnancy after Elimination of Embryo Fragments Before Fresh Cleavage-Stage Embryo Transfer

Sordia-Hernández

Morales-Martínez

Frazer-Moreira

et al. 2020

JFRH

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Objective: To determine if the elimination of fragments in cleavage-stage embryos, before fresh transfer, improves pregnancy rates in in vitro fertilization cycles. Materials and methods: This is a Prospective observational case-control study carried out at a University Reproductive Center. We included Twenty-six infertile patients divided into two groups. Group one: 13 patients with embryos classified as grade B and C (embryos with fragments) according to the Hill classification, and Group two: 13 patients with grade A embryos (embryos with no fragments). Embryo Defragmentation was performed in embryos of group one 65 to 68 hours after conventional fertilization. Fresh embryo transfer was made after two hours post fragments removal. Reproductive results were evaluated and compared between both groups. Results: The total number of clinical pregnancies was nine. In group one there were 5 (38.5 %); in group two, there were 4 (30.8%). The difference was not statistically significant (p = 0.68). Two abortions were reported in the study, both in group one; were fragment elimination was performed. This represents an abortion rate of 40% in patients who got pregnant in this group. These patients had twice the probability of suffering an abortion (OR 2.1; 95% CI 1.4-3.37). Ongoing pregnancies were similar in both groups. Conclusion: Removal of fragments in freshly transferred day three embryos could be an alternative to increase clinical pregnancy and ongoing pregnancy rates in patients who have only poor-quality embryos. Despite the relationship with a higher abortion rate, this strategy could represent a real alternative for this type of patient.

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Section: Discussionmentioning

confidence: 99%

“…The formation of fragments has been related to a variety of factors. Among these, inadequate embryo culture, poor egg and/or sperm quality, advanced maternal age, apoptosis, and oxidative stress in embryos ( 6 ).…”

Section: Introductionmentioning

confidence: 99%