Effect of emamectin benzoate on transcriptional expression of cytochromes P450 and the multidrug transporters (Pgp and MRP1) in rainbow trout (Oncorhynchus mykiss) and the sea lice Caligus rogercresseyi

Frequent haplotypes of caged Caligus rogercresseyi in the austral south of Chile: The result of a long term serial passage experiment?

“…The results here are similar to those of SPEs, which are characterized by repeated population bottlenecks (Ebert, 1998). As previously mentioned, the loss of sensitivity to EMB has been demonstrated in C. rogercresseyi (Bravo et al, 2008), and a doubling in the expression of its cytochrome CYP3A27 occurs when it is exposed to this substance (Cárcamo et al, 2011). In its host, treatment with EBM regulates the transcriptional expression of proteins involved in metabolism, distribution and elimination of endobiotics and xenobiotics, such as hormones and drugs, and could even affect the pharmacokinetics of EMB in the same treatment.…”

Emamectin benzoate (Proclaim®) mediates biochemical changes and histopathological damage in the kidney of male Wistar rats (Rattus norvegicus)

“…Avermectin has previously been reported to be a potent inhibitor of P-glycoprotein, which is extremely important in transport regulation and elimination of a wide range of xenobiotics, including pesticides [35]. Cárcamo et al [36] showed that exposure of rainbow trouts to pharmacological EMB concentrations altered the transcriptional responses of xenobiotic biotransformation proteins and extrusion transporters. EMB increases CYP3A expression in kidney and intestine samples and it is wellknown that CYP3A enzymes participate strongly in drug interactions [37,38].…”

Transcriptomic responses to emamectin benzoate in Pacific and Atlantic Canada salmon lice Lepeophtheirus salmonis with differing levels of drug resistance

“…However, EMB‐induced fold change may be moderate; Chilean EMB‐resistant Caligus rogercresseyi only had moderate differences in expression of detoxification (e.g., cytochrome P450s) or transport genes ( multidrug resistance protein 1 (mrp1); Pgp1) as detected by semi‐quantitative PCR (Cárcamo et al. ).…”

“…EMB‐resistant Chilean C. rogercresseyi did not upregulate heat‐shock protein from EMB (Cárcamo et al. ), and no stress response was identified in the spot prawn Pandalus platyceros exposed to EMB, although other biological functions were affected (e.g., transcription/translation control; Veldhoen et al. ).…”