Effect of electron beam irradiation dose on the properties of commercial biodegradable poly(lactic acid), poly(butylenes adipate-co-terephthalate) and their blends

Enhanced Photodegradation Stability in Poly(butylene adipate-co-terephthalate) Composites Using Organically Modified Layered Zinc Phenylphosphonate

“…Under irradiation, the exposed aromatic rings can be oxidized to phenoxy radicals, which cause the yellowing of the polymer due to their strong absorbance in the visible region. The yellowing phenomenon of the PBAT, which follows a similar mechanism, was reported [ 42 , 43 , 44 ]. The yellowing phenomenon is due to the oxidation of the benzene ring, and the dYI is used to determine the photodegradation of the PBA.…”

Sterilization of Polymeric Implants: Challenges and Opportunities

“…Similar effects of E-beam sterilization on polymeric scaffold porosity, 41,50,52 degradation profiles, 34,53,54 mechanical integrity, 50,54 and thermosensitive behaviors have been reported. 50,54 Despite their utility in sterilizing some degradable polymers, the vulnerability of labile linkages and cross-links such as ester bonds to high energy irradiation should always be considered and evaluated case by case. If these class A sterilization methods are to be implemented, the physical, mechanical, and biological properties of the material poststerilization should be fully characterized and reported.…”

“…Marked reduction in osteoinductive properties has also been documented on allogenic bone grafts post-gamma-irradiation sterilization, ,, likely due to damage to the chemical and structural integrity of osteoinductive/angiogenic protein factors and other naturally occurring biopolymers, resulting in poorer osteointegration of the grafts. Similar effects of E-beam sterilization on polymeric scaffold porosity, ,, degradation profiles, ,, mechanical integrity, , and thermosensitive behaviors have been reported. , Despite their utility in sterilizing some degradable polymers, the vulnerability of labile linkages and cross-links such as ester bonds to high energy irradiation should always be considered and evaluated case by case. If these class A sterilization methods are to be implemented, the physical, mechanical, and biological properties of the material poststerilization should be fully characterized and reported.…”

How to Sterilize Polylactic Acid Based Medical Devices?

“…E-beam sterilization uses high-energy beams from accelerators to irradiate biomaterials or medical devices in their final packages and inactivates micro-organisms by the same mechanisms as gamma irradiation [ 3 , 4 ]. It is important to note that for this sterilisation, the correct dose is one of the most essential factors as it is directly related to the sterility assurance level of the biomedical device and to the penetration of the electrons, as higher doses are needed for thicker products due to their lower penetration capacity [ 48 ].…”

“…Zhao et al also demonstrated that the decrease in molecular weight is induced by irradiation. They studied the effect of dose ranging frome 25 up to 100 kGy and found a severe reduction of glass transition and melting temperatures, as well as a severe reduction in the mechanical properties of commercial PLA, when subjected to higher doses of electron beam irradiation [ 48 ]. In other articles focussed on sterilization by e-beam radiation, the samples were irradiated with the aid of one or two linear electron accelerators with 10 MeV energy and with radiation doses of 25 kGy, according to ISO 11137-2:2006 [ 27 , 37 ].…”