Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis: a single-blind, randomized pilot study

Giordano, Nicola Giuseppe; Battisti, Emilio; Geraci, Simone; Fortunato, Marco; Santacroce, Clorinda; Rigato, M.; Gennari, Luigi; Gennari, C

doi:10.1016/s0011-393x(01)80030-8

Cited by 53 publications

(61 citation statements)

References 17 publications

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“…There have been a number of experiments in animal models of osteopenia that support such a beneficial effect after mechanical unloading [Bassett et al, 1979;Cruess and Bassett, 1983;Rubin et al, 1989;Skerry et al, 1991;Shen and Zhao, 2010] or ovariectomy [Zati et al, 1993;Bilotta et al, 1994;Chang and Chang, 2003]. On the other hand, we found only a few reports of the attempt to improve bone density in humans using low frequency or PEMFs in osteoporosis [Tabrah et al, 1990[Tabrah et al, , 1998Bilotta et al, 1994;Giordano et al, 2001], or in other situations [Eyres et al, 1996;Garland et al, 1999] but they were generally small and/or not well controlled.…”

Section: Introductionmentioning

confidence: 83%

Electromagnetic effects on forearm disuse osteopenia: A randomized, double-blind, sham-controlled study

Spadaro

Short

Sheehe

et al. 2010

Bioelectromagnetics

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A randomized, double-blind, sham-controlled, feasibility and dosing study was undertaken to determine if a common pulsing electromagnetic field (PEMF) treatment could moderate the substantial osteopenia that occurs after forearm disuse. Ninety-nine subjects were randomized into four groups after a distal radius fracture, or carpal surgery requiring immobilization in a cast. Active or identical sham PEMF transducers were worn on the distal forearm for 1, 2, or 4 h/day for 8 weeks starting after cast removal ("baseline") when bone density continues to decline. Bone mineral density (BMD) and bone geometry were measured in the distal forearm by dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) at entry ("baseline") and 8, 16, and 24 weeks later. Significant average BMD losses after baseline were observed in the affected forearm at all time points (5-7% distally and 3-4% for the radius/ulna shaft). However, after adjusting for age, gender, and baseline BMD there was no evidence of a positive effect of active versus sham PEMF treatment on bone loss by DXA or pQCT for subjects completing all visits (n = 82, ∼20 per group) and for an intent-to-treat analysis (n = 99). Regardless of PEMF exposure, serum bone-specific alkaline phosphatase (BSAP) was normal at baseline and 8 weeks, while serum c-terminal collagen teleopeptide (CTX-1) was markedly elevated at baseline and less so at 8 weeks. Although there was substantial variability in disuse osteopenia, these results suggested that the particular PEMF waveform and durations applied did not affect the continuing substantial disuse bone loss in these subjects.

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Section: Introductionmentioning

confidence: 83%

Electromagnetic effects on forearm disuse osteopenia: A randomized, double-blind, sham-controlled study

Spadaro

Short

Sheehe

et al. 2010

Bioelectromagnetics

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“…Trials to apply ELFMFs for clinical use have been also investigated, and the clinical efficacy of various types of ELFMFs (from the perspectives of frequency, intensity, and waveform) has been recently demonstrated in the treatment of osteoporosis [Giordano et al, 2001], osteoarthritis of the knee [Jacobson et al, 2001], and Parkinsonism [Sandyk, 1996]. Giordano et al demonstrated that a significant increase in serum osteocalcin and serum procollagen type I C-terminal peptide was observed by treatment with 100 Hz pulsed electromagnetic fields in women outpatients with postmenopausal osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Sakurai

Yoshimoto

Koyama

et al. 2007

Bioelectromagnetics

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To evaluate the effects of extremely low frequency magnetic field (ELFMF) on beta-cell survival and function, we cultured a hamster-derived insulin-secreting cell line (HIT-T15), which exhibits responsiveness to glucose in a semi-physiological range, under exposure to sham and ELFMF conditions, and assessed cell survival and function. We used our previously developed ELFMF exposure unit (a sinusoidal magnetic field at a frequency of 60 Hz, 5 mT) to culture cells under exposure to ELFMF conditions. We found that exposure to ELFMF for 5 days in the absence of glucose increased cell number, exposure for 2 days in the absence of glucose and for 5 days with 100 mg/dl glucose increased the insulin secretion to the culture medium, and exposure for 2 and 5 days with 40 and 100 mg/dl glucose increased intracellular insulin concentration in HIT-T15 cells. The increase in cell number under apoptotic culture conditions by exposure to ELFMF could lead to new therapeutic concepts in the treatment of diabetes. The ELFMF-induced increase in intracellular insulin concentration could be utilized to develop culture conditions to enhance intracellular insulin concentration in insulin-secreting cells that would be useful for cell transplantation to cure diabetes mellitus.

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“…Previously, the beneficial effects of magnetic fields on inflammation [2], osteoporosis [3], wound healing [4], and pain reduction [5] have been demonstrated by a plenty of intriguing studies using laboratory animals in vivo. Meanwhile, the frequency of exposure to SMFs has also increased rapidly, such as magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) [6], which have been used in hospitals as noninvasive diagnostic tools.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Static Magnetic Fields Affects Insulin Secretion in INS Cells

Mao

Guo

Wang

et al. 2015

Lecture Notes in Electrical Engineering

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The exposure to static magnetic fields (SMFs) has rapidly increased and is recently accompanied with the wide use of more and more electrical appliances. Although few researches have been reported on other types of magnetic fields that may have the effects on clinical therapy of diseases, it is rarely seen reports on the effects of moderate static magnetic fields on human health. In this study, in order to evaluate the influence of exposure to moderate static magnetic fields on biological systems, we cultured the INS-1 under exposure to moderate intensity of 400 mT and sham conditions for different times from 6 to 18 h, insulin secretion to medium and mRNA expression will be tested after exposure. Insulin secretion has significantly increased after exposed to SMFs with moderate intensity of 400 mT for 18 h compared with the sham condition. Furthermore, similar to the insulin secretion, insulin 1 and insulin 2 mRNA expression also increased after exposure. These results suggest that exposure to SMFs at 400 mT position for specific times might have positive stimulation in both insulin secretion and insulin mRNA expression, and these will be used hopefully in further investigations in vitro, even in the therapy clinically.

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Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis: a single-blind, randomized pilot study

Cited by 53 publications

References 17 publications

Electromagnetic effects on forearm disuse osteopenia: A randomized, double-blind, sham-controlled study

Electromagnetic effects on forearm disuse osteopenia: A randomized, double-blind, sham-controlled study

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Exposure to Static Magnetic Fields Affects Insulin Secretion in INS Cells

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