Effect of Electrolyzed Water on Wound Healing

Yahagi, Naoki; Kono, Michihito; Kitahara, Masaki; Ohmura, Akito; Sumita, Osao; Hashimoto, Toshimasa; Hori, Katsuaki; Chen, Ningjuan; Woodson, Paul B.J.; Kubota, Shôji; Murakami, Arata; Takamoto, Shinichi

doi:10.1046/j.1525-1594.2000.06557-3.x

Cited by 43 publications

(41 citation statements)

References 8 publications

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“…SOW does not cause harmful effect on the human tissues and used for various conditions like wound, skin infections, ulcers and diabetic foot (2,3). The other forms of this formulation were not neutral pH and has a strong acid aqueous ingredient and theoretically may lead to toxic and negative effect on the tissue and subcellular level (4).…”

Section: Introductionmentioning

confidence: 99%

The effect of super-oxidized water on the tissues of uterus and ovary: An experimental rat study

Aras¹,

Karaman²,

Çim³

et al. 2017

Eastern J Med

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Section: Introductionmentioning

confidence: 99%

The effect of super-oxidized water on the tissues of uterus and ovary: An experimental rat study

Aras¹,

Karaman²,

Çim³

et al. 2017

Eastern J Med

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“…Its application has been investigated in medical [13][14][15][16][17], dental, animal husbandry, horticulture, restaurant and other areas where microbial growths are known to present potential health threats [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Disinfecting the acrylic resin plate using electrolyzed acid water and 2% glutaraldehyde: a comparative microbiological study

Jnanadev¹,

Babu²,

Shetty³

et al. 2011

J Indian Prosthodont Soc

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Marked bactericidal activity of the electrolyzed acid water (EAW) and its less undesirable effects on biological tissues and the environment has been successfully utilized in dental practice. A review of literature reveals that not many studies have been performed to determine the disinfection effect of EAW on heat cured acrylic denture bases. The objective of the study is to determine the efficacy of EAW in disinfecting heat cured acrylic resin specimens as compared to the efficacy of disinfecting the specimens using 2% glutaraldehyde. Heat cured acrylic resin plates were immersed in Bacteria suspensions of Staphylococcus aureus and later disinfected using EAW which was produced using a custom made electrolyzing apparatus and 2% glutaraldehyde for different time intervals. The numbers of surviving bacteria were counted. As the control, the bacteria attached on the specimens were counted with out any disinfection treatment. The results obtained were statistically analyzed using ANOVA and post-hoc test. The disinfection potential of 2% glutaraldehyde was better than EAW when the specimens were disinfected for 1 and 3 min. Where as when the disinfection time was increased to 5 min there was no difference between EAW and 2% glutaraldehyde. However considering that the disinfecting time can be easily extended to 5 min, EAW can be effectively used for disinfecting the acrylic denture.

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“…12) Another study testing different waters concluded that the wound healing effect may be due to the free radicals, and the other in vivo study proposed that acidic water enhances epithelialization, collagen deposition and increase of inflammatory cells. 15,16) Despite these studies in relation to wound healing, the exact mechanism of the healing effect is still unknown.…”

mentioning

confidence: 99%

Wound Healing Effect of Slightly Acidic Electrolyzed Water on Cutaneous Wounds in Hairless Mice <i>via</i> Immune-Redox Modulation

You

Fadriquela

Sajo

et al. 2017

Biological & Pharmaceutical Bulletin

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Acidic electrolyzed water is an innovative sanitizer having a wide-spectrum of applications in food industry, and healthcare industry but little is known on its effect and mechanism in wound healing. The study was conducted to identify the effect and mechanism of slightly acidic electrolyzed water (SAEW) on cutaneous wounds in hairless mice. SAEW (pH: 5-6.5, oxidation reduction potential: 800 mV, chlorine concentration: 25 ppm) was prepared through electrolysis of water and was applied to the wounds of hairless mice three times a day for seven days. Wound size, immune response and oxidative stress were explored and compared to conventional agents such as Betadine and alcohol. We found that SAEW-treated group showed the highest wound reduction percentage ( p<0.01). Antioxidant activities such as glutathione peroxidase, catalase and myeloperoxidase activities of SAEW group surpassed the total reactive oxygen species in skin. Nuclear factor erythroid-2-related-factor-2 and aryl hydrocarbon receptor were upregulated in SAEW group. Further, SAEW recruited the production of intracellular calcium and promoted its utilization for faster healing. In line, SAEW treatment decreased pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, keratinocyte chemoattractant, and tumor necrosis factor-α] in serum. Other hallmarks of wound healing, matrixmetalloproteinases (MMP)1 and MMP9 were also upregulated. Collectively, our study indicates that SAEW is effective in wound healing of hairless mice via immune-redox modulation, and heals better/faster than conventional agents.Key words slightly acidic electrolyzed water; wound healing; oxidative stress; immune response Skin injuries, such as cutaneous wounds, need to undergo a complex mechanism to repair the damage. Wound healing is comprised of four sequential but overlapping stages; homeostasis, inflammation, proliferation, and remodeling, strongly regulated with the goal of restoring the integrity of the skin.

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Effect of Electrolyzed Water on Wound Healing

Cited by 43 publications

References 8 publications

The effect of super-oxidized water on the tissues of uterus and ovary: An experimental rat study

The effect of super-oxidized water on the tissues of uterus and ovary: An experimental rat study

Disinfecting the acrylic resin plate using electrolyzed acid water and 2% glutaraldehyde: a comparative microbiological study

Wound Healing Effect of Slightly Acidic Electrolyzed Water on Cutaneous Wounds in Hairless Mice <i>via</i> Immune-Redox Modulation

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