Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence

Liu, Zhishun; Liu, Yan; Xu, Haiyan; He, Liyun; Chen, Yuelai; Fu, Lei; Li, Ning; Lu, Yonghui; Su, Tongsheng; Sun, Jianhua; Wang, Jie; Yue, Zeng-Hui; Zhang, Wei; Zhao, Jiping; Zhou, Zhongyu; Wu, Jiani; Zhou, Kehua; Ai, Yanke; Zhou, Jing; Pang, Ruoming; Wang, Yang; Qin, Zongshi; Yan, Shiyan; Li, Hongjiao; Luo, Lin; Liu, Baoyan

doi:10.1001/jama.2017.7220

Cited by 276 publications

(222 citation statements)

References 35 publications

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“…Electroacupuncture (EA), the application of a pulsating electrical current to acupuncture needles for acupuncture point stimulation, is a modern way of administering acupuncture in clinical practice and for research. EA has been shown to be effective in the treatment of various gastrointestinal diseases, including POI …”

Section: Introductionmentioning

confidence: 99%

Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice

Yang

Tian

et al. 2020

Neurogastroenterology Motil

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Postoperative ileus (POI) is a frequent complication of abdominal surgery characterized by transient hypomotility of the gastrointestinal tract and presents as an inability to tolerate enteral nutrition, nausea, and lack of passage of flatus and stool, along with abdominal distension. 1 Acute early activation of inhibitory neural pathways and secondary late inflammatory responses are considered to be the main pathological mechanisms of POI. 2 This condition accounts for prolonged hospitalization and increased risks of aspiration and infectiousAbstract Background: Electroacupuncture (EA) is widely used in various gastrointestinal diseases around the world, including POI. Here, we investigated different therapeutic effects of EA using lower limb and abdomen acupoints. Methods: Intestinal manipulation was performed in 88 mice, and eight mice underwent a sham operation. Forty mice were randomly divided into model group and four EA groups receiving stimulation at ST36 (2, 10, 30, 100 Hz). The most effective frequency was then used in the following experiments. Forty-eight mice were randomly divided into six groups receiving EA treatment at ST37, ST39, ST25, CV4, CV12, and a non-acupuncture point. Gastrointestinal motility and plasma TNF-α, IL-6 were evaluated in all mice. The local immune response and α-smooth muscle actin (α-SMA) expression were assessed by immunofluorescence, ELISA, and HE staining.Results: ST36 stimulated with 10 or 30 Hz EA significantly increased the gastrointestinal motility and attenuated peripheral inflammation; however, ST36 stimulated with 2 or 100 Hz did not induce any effect. The therapeutic effects on motility and inflammation of 10 Hz EA in the ST36 group were similar in the ST36, ST37, ST39, or CV4 groups, but when applied to ST25, CV12 or non-acupoint had no significant differences. EA at ST36, ST37, ST39, or CV4 significantly inhibited local MPO activity, immune cells infiltration, and increased α-SMA.Conclusions: EA at lower limb and abdomen acupoints with the same stimulation parameters had different therapeutic effects on postoperative dysmotility and inflammation. Furthermore, EA protected SMC to improve gastrointestinal transit by reducing local inflammation in the intestinal musculature in POI. K E Y W O R D Sacupoints, gastrointestinal motility, myeloperoxidase, α-SMA

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Section: Introductionmentioning

confidence: 99%

Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice

Yang

Tian

et al. 2020

Neurogastroenterology Motil

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“…The evidence around the role of acupuncture for UI is increasing, and positive trials exist for the management of SUI . However, the explicit mechanisms and factors affecting such efficacy remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The participants, outcome assessors and statisticians were blinded to interventions. Details of the study sample, methods and primary results have been published elsewhere . Of 252 patients assigned to the EA group, we identified 86 as obese and 166 as non‐obese in the secondary analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The evidence around the role of acupuncture for UI is increasing, and positive trials exist for the management of SUI. 16,17,36 However, the explicit mechanisms and factors affecting such efficacy remain unknown. Causing muscle contraction and simulating PFMT by stimulating S3 via BL33 (Zhongliao) and the pudendal nerve via BL35 (Huiyang) have been considered as a plausible explanation of acupuncture for SUI.…”

Section: International Consultation On Incontinence Questionnaire-shortmentioning

confidence: 99%

“…We have conducted two separate randomised controlled trials of electroacupuncture (EA) for the treatment of SUI and S‐MUI. In a randomised controlled trial of EA vs sham EA (SA) for SUI, we found that EA involving the lumbosacral region led to a greater reduction in the amount of urine leakage than SA. In the second trial of EA vs PFMT plus solifenacin for MUI, we observed that EA involving the same acupoints was not inferior to PFMT plus solifenacin at decreasing the 72‐hours incontinence episode frequency (IEF) for S‐MUI.…”

Section: Introductionmentioning

confidence: 97%

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Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Wang

Liu

et al. 2019

Int J Clin Pract

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Objective To explore whether obesity patients with a body mass index (BMI) of ≥25 kg/m2 who suffer from stress urinary incontinence (SUI) or stress‐predominant mixed urinary incontinence (S‐MUI) show less improvement in urinary incontinence (UI) symptoms after electroacupuncture (EA) treatment compared with non‐obese counterparts. Methods This study was a secondary analysis of existing data. About 252 SUI patients and 250 S‐MUI patients treated with the same EA regimen were assigned to one of the two groups: the obesity group for BMI ≥25 kg/m2 and the non‐obesity group for BMI <25 kg/ m2. The primary outcome was the proportion of treatment responders, defined as patients exhibiting a ≥50% reduction in 72‐hours incontinence episode frequency, as measured by a 72‐hours bladder diary at week 6 compared with baseline. Results Of the 1004 randomised women, 129 obese women (86 SUI and 43 S‐MUI) and 255 non‐obese women (166 SUI and 89 S‐MUI) treated with EA were included in a secondary analysis. The primary outcome was that 58.3% (74/127) of patients in the obesity group and 60.7% (150/247) of patients in the non‐obesity group (difference 0.55%; 95% confidence interval, −10.01 to 11.11; P = .919) responded to treatment. Conclusion This study suggests that EA treatment may safely improve UI symptoms in both obese and non‐obese patients, regardless of BMI category. Additionally, obesity status may not affect the efficacy of EA treatment on SUI or S‐MUI among Chinese women.

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Acupuncture for Stress Urinary Incontinence

Wang¹

2017

JAMA

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Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence

Abstract: clinicaltrials.gov Identifier: NCT01784172.

Cited by 276 publications

References 35 publications

Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice

Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice

Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Acupuncture for Stress Urinary Incontinence

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