Effect of electroacupuncture at ST36 on the cerebral metabolic kinetics of rheumatoid arthritis rats

Liang, Fangyuan; Lei, Du; Rao, Xiaoping; Li, Ying; Long, Wei; Tian, Jie; Zhu, Xinhong; Zou, Ai-Ping; Lü, Wei; Wan, Bi-jiang

doi:10.1016/j.brainresbull.2023.110700

Cited by 2 publications

(2 citation statements)

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“…Electroacupuncture, a type of acupuncture, offers enhanced ease of operation, increased objectivity and reproducibility in comparison with manual acupuncture. 42 The selection of acupuncture points plays a pivotal role in the effectiveness of acupuncture treatment. Research has demonstrated that stimulation at Zusanli (ST36) can activate the body's endogenous regulatory system to combat inflammation by inhibiting the increase in macrophage M1/M2 ratio and the expression of pro-inflammatory cytokines.…”

Section: ■ Introductionmentioning

confidence: 99%

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Self-Assembled Multilayer-Modified Needles Simulate Acupuncture and Diclofenac Sodium Delivery for Rheumatoid Arthritis

Wang,

Cheng,

Song

et al. 2024

ACS Appl. Mater. Interfaces

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A novel therapeutic approach combining acupuncture and diclofenac sodium (DS) administration was established for the potential treatment for rheumatoid arthritis (RA). DS is a commonly used anti-inflammatory and analgesic drug but has short duration and adverse effects. Acupoints are critical linkages in the meridian system and are potential candidates for drug delivery. Herein, we fabricated a DS-loaded multilayer-modified acupuncture needle (DS-MMAN) and investigated its capacity for inhibiting RA. This DS-MMAN possesses sustained release properties and in vitro anti-inflammatory effects. Experimental results showed that the DS-MMAN with microdoses can enhance analgesia and efficiently relieve joint swelling compared to the oral or intraarticular administration of DS with gram-level doses. Moreover, the combination of acupoint and DS exerts a synergistic improvement in inflammation and joint damage. Cytokine and T cell analyses in the serum indicated that the application of DS-MMAN suppressed the levels of pro-inflammatory factors and increased the levels of anti-inflammatory factors. Furthermore, the acupoint administration via DS-MMAN could decrease the accumulation of DS in the liver and kidneys, which may express better therapeutic efficiency and low toxicity. The present study demonstrated that the acupuncture needle has the potential to build a bridge between acupuncture and medication, which would be a promising alternative to the combination of traditional and modern medicine.

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Section: ■ Introductionmentioning

confidence: 99%

“…Electroacupuncture, a type of acupuncture, offers enhanced ease of operation, increased objectivity and reproducibility in comparison with manual acupuncture . The selection of acupuncture points plays a pivotal role in the effectiveness of acupuncture treatment.…”

Section: Introductionmentioning

confidence: 99%