Effect of Electrical Stimulation on Nerve-Guided Facial Nerve Regeneration

Choe, Goeun; Han, Ul Gyu; Ye, Seongryeol; Kang, Sujee; Yoo, Jin; Cho, Young Sang; Jung, Youngmee

doi:10.1021/acsbiomaterials.3c00222

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Effective proliferation and differentiation of seed cells, cell-cell interactions, and stimulation and regulation of biological molecules provide great help for the process of facial nerve regeneration [30,31]. In addition, the conductivity [32], plasticity and degradability of the conduits should also be considered.…”

Section: Requirements Of the Tissue Engineering Nerve Conduitsmentioning

confidence: 99%

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Sun,

Cao,

Pan

et al. 2024

Molecules

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The prevalence of facial nerve injury is substantial, and the restoration of its structure and function remains a significant challenge. Autologous nerve transplantation is a common treatment for severed facial nerve injury; however, it has great limitations. Therefore, there is an urgent need for clinical repair methods that can rival it. Tissue engineering nerve conduits are usually composed of scaffolds, cells and neurofactors. Tissue engineering is regarded as a promising method for facial nerve regeneration. Among different factors, the porous nerve conduit made of organic materials, which has high porosity and biocompatibility, plays an indispensable role. This review introduces facial nerve injury and the existing treatment methods and discusses the necessity of the application of porous nerve conduit. We focus on the application of porous organic polymer materials from production technology and material classification and summarize the necessity and research progress of these in repairing severed facial nerve injury, which is relatively rare in the existing articles. This review provides a theoretical basis for further research into and clinical interventions on facial nerve injury and has certain guiding significance for the development of new materials.

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Section: Requirements Of the Tissue Engineering Nerve Conduitsmentioning

confidence: 99%

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Sun,

Cao,

Pan

et al. 2024

Molecules

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“…Overall, we believe that ideal NGCs should possess a certain degree of porosity. In addition to porosity, functional NGCs with specific properties have increasingly emerged as effective strategy to enhance PNR by providing external neural stimulation, such as electrical [79,80], magnetic [81,82], piezoelectric [83,84], photoacoustic [85],and ultrasound [86, 87] stimulations, or enabling controlled release of drugs and growth factors with the aid of external magnetic field [88, 89], ultrasound stimulation [90, 91], and photothermal effect [92,93].…”

Section: Other Propertiesmentioning

confidence: 99%

Scaffold design considerations for peripheral nerve regeneration

Yu,

Bennett,

Lin

et al. 2024

J. Neural Eng.

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Peripheral nerve injury (PNI) represents a serious clinical and public health problem due to its high incurrence and poor spontaneous recovery. Compared to autograft, which is still the best current practice for long-gap peripheral nerve defects in clinics, the use of polymer-based biodegradable nerve guidance conduits (NGCs) has been gaining momentum as an alternative to guide the repair of severe PNI without the need of secondary surgery and donor nerve tissue. However, simple hollow cylindrical tubes can barely outperform autograft in terms of the regenerative efficiency especially in critical sized PNI. With the rapid development of tissue engineering technology and materials science, various functionalized NGCs have emerged to enhance nerve regeneration over the past decades. From the aspect of scaffold design considerations, with a specific focus on biodegradable polymers, this review aims to summarize the recent advances in NGCs by addressing the onerous demands of biomaterial selections, structural designs, and manufacturing techniques that contributes to the biocompatibility, degradation rate, mechanical properties, drug encapsulation and release efficiency, immunomodulation, angiogenesis, and the overall nerve regeneration potential of NGCs. In addition, several commercially available NGCs along with their regulation pathways and clinical applications are compared and discussed. Lastly, we discuss the current challenges and future directions attempting to provide inspiration for the future design of ideal NGCs that can completely cure long-gap peripheral nerve defects.

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“…PNI can lead to lifelong disability in patients with neuropathic pain, depending on the severity of the injury (Yi et al, 2019;Davoli-Ferreira et al, 2020;Idrisova et al, 2022;Sharifi et al, 2023;Xiong et al, 2023). As the regeneration rate of damaged peripheral nerves is approximately 1 mm per day, the strategies and outcomes of clinical treatment on PNI usually depend on the different types of injury and the distances of the gaps (Seddon et al, 1943;Sunderland, 1947;Juckett et al, 2022;Zhang et al, 2023a;Choe et al, 2023). Moreover, patients may need multiple surgeries and extended hospitalizations, which places a financial burden on the healthcare system (Padovano et al, 2022;Dong et al, 2023).…”

mentioning

confidence: 99%

Progress in methods for evaluating Schwann cell myelination and axonal growth in peripheral nerve regeneration via scaffolds

Ling,

He,

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Peripheral nerve injury (PNI) is a neurological disorder caused by trauma that is frequently induced by accidents, war, and surgical complications, which is of global significance. The severity of the injury determines the potential for lifelong disability in patients. Artificial nerve scaffolds have been investigated as a powerful tool for promoting optimal regeneration of nerve defects. Over the past few decades, bionic scaffolds have been successfully developed to provide guidance and biological cues to facilitate Schwann cell myelination and orientated axonal growth. Numerous assessment techniques have been employed to investigate the therapeutic efficacy of nerve scaffolds in promoting the growth of Schwann cells and axons upon the bioactivities of distinct scaffolds, which have encouraged a greater understanding of the biological mechanisms involved in peripheral nerve development and regeneration. However, it is still difficult to compare the results from different labs due to the diversity of protocols and the availability of innovative technologies when evaluating the effectiveness of novel artificial scaffolds. Meanwhile, due to the complicated process of peripheral nerve regeneration, several evaluation methods are usually combined in studies on peripheral nerve repair. Herein, we have provided an overview of the evaluation methods used to study the outcomes of scaffold-based therapies for PNI in experimental animal models and especially focus on Schwann cell functions and axonal growth within the regenerated nerve.

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Effect of Electrical Stimulation on Nerve-Guided Facial Nerve Regeneration

Cited by 4 publications

References 37 publications

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Scaffold design considerations for peripheral nerve regeneration

Progress in methods for evaluating Schwann cell myelination and axonal growth in peripheral nerve regeneration via scaffolds

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