Effect of Electrical Field Stimulation on Dorsal Root Ganglion Neuronal Function

Dorsal Root Ganglion Stimulation for Chronic Pelvic Pain: A Case Series and Technical Report on a Novel Lead Configuration

“…Similarly, stimulation of the S2 DRG will interrupt signals from the lower portion of the lumbar (L5/S1) plexus, the entire sacral plexus and S2–3; this should provide sufficient coverage to disrupt afferent input from the foot and toes as well as pelvic pain originating from pudendal nerve (S2‐S4) and sacral splanchnic sympathetic plexus. At the dorsal horn, upstream from the DRG, DRGS reduces the hyperexcitable sodium channels and increases the calcium ion influx, thus decreasing the firing of both Aδ and C fibers that innervate lamina I (marginal zone) and lamina II (substantia gelatinosa) in the anterolateral system .…”

The Dorsal Root Ganglion in Chronic Pain and as a Target for Neuromodulation: A Review

“… wrote that “a change in neuronal activity (electrical stimulation) can alter the expression of sodium channel genes in a subtype‐specific manner.” Koopmeiners et al. showed that electrical field stimulation of the DRG increases Ca ++ influx into DRG neurons, decreases the frequency of multiple action potentials within DRG neurons, and significantly reduces conduction velocity when compared with baseline before stimulation. Figure and Table summarize this hypothesis of the mechanism of action of electrical stimulation of the DRG for the control of aberrant pain.…”

Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial

“…Animal models of chronic pain have shown that pathophysiologic changes occur in the DRG, including altered electrophysiological membrane properties, altered expression of integral membrane proteins, and altered expression of various genes that contribute to the hyperexcitability of neurons. 15 The combination of the DRG's sensory function and accessibility through familiar epidural approaches make it an ideal target for neurostimulation. Pain therapies targeting the DRG included radiofrequency frequency ablation, steroid injections, and ganglionectomy.…”