Abstract:The self-association of amylogenic proteins to the fibril form is considered a pivotal factor in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). PD causes unintended or uncontrollable movements in its common symptoms. α-synuclein is the major cause of PD development and thus has been the main target of numerous studies to suppress and sequester its expression or effectively degrade it. Nonetheless, to date, there are no efficient and proven ways to prevent pathological prote… Show more
“…Razzokov et al performed molecular dynamics (MD) simulations on extremely hazardous α-synuclein fibrils to obtain a molecular-level understanding of fibril disruption mechanisms. Their findings revealed that the applied external electric field significantly alters the structure of αsyn fibrils, in addition to highlighting the critical electric field intensity at which the hydrophobic core of αsyn fibrils can be fully opened [ 17 ].…”
“…Razzokov et al performed molecular dynamics (MD) simulations on extremely hazardous α-synuclein fibrils to obtain a molecular-level understanding of fibril disruption mechanisms. Their findings revealed that the applied external electric field significantly alters the structure of αsyn fibrils, in addition to highlighting the critical electric field intensity at which the hydrophobic core of αsyn fibrils can be fully opened [ 17 ].…”
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