Effect of elcatonin on experimental gastric and duodenal ulcers.

Ohno, Hiroshi; Noguchi, M.; Takayanagi, Noriyasu

doi:10.1254/jjp.37.67

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Intestinal absorption of calcium is increased by CT . Elcatonin, a synthetic eel calcitonin, has been shown to inhibit gastric and duodenal ulcers . Calcitonin receptor‐like receptors have been localized to the human GI tract, and the peptide hormone gastrin, responsible for the secretion of gastric acid by parietal cells, significantly upregulates CT secretion ,,.…”

Section: Physiological Rolessupporting

confidence: 58%

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Kamgar-Parsi

Tolchard

Habenstein

et al. 2016

Israel Journal of Chemistry

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Under appropriate conditions, peptides and proteins can assemble from their native state into prefibrillar oligomers and then mature into fibrillar aggregates. This transition forms the molecular basis of several pathologies, often related to the deposition of these amyloid fibrils. Several hormone peptides involved in fundamental biological processes have the tendency to self‐assemble into amyloid fibrils, resulting in a loss of their native functions, and more importantly, entailing devastating consequences, such as the formation of amyloid depositions. Calcitonin is a 32 amino‐acid hormone peptide that can be considered a molecular paradigm for the central events associated with hormone misfolding. Calcitonin in its native form is involved in various physiological functions, including mediating calcium homeostasis and maintaining bone structure. It is the latter function that has motivated the use of calcitonin as an aqueous therapeutic agent for the treatment of bone‐related pathologies such as osteoporosis and Paget's disease. Despite some success as a therapeutic, calcitonin's ability to control these diseases is limited by its aggregation along the canonical amyloid aggregation pathway, compromising its long‐term stability as a therapeutic agent. A better understanding of the misfolding process would not only provide the structural basis to improve calcitonin's long‐term stability and activity as a therapeutic, but also provide valuable insights into pathological aggregation of other amyloids. In this work, we review the physiological roles of calcitonin, its structure, and aggregation process, and consider the effects of calcitonin's structure on its role as a therapeutic.

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Section: Physiological Rolessupporting

confidence: 58%

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Kamgar-Parsi

Tolchard

Habenstein

et al. 2016

Israel Journal of Chemistry

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“…These results suggest that this peripheral activity of (Asu1,7) eel-Calcitonin does not involve a direct interference with cholinergic, histaminergic or serotoninergic pathways at gastric level. At the same time Ohno et al 20 For the sake of historical justice, it should be noted that the gastroprotective effect (by pylorus ligation) of salmon calcitonin was discovered back in 1983 in the USSR 23 , but remained invisible to the scientific community, probably because of the iron curtain.…”

Section: Discussionmentioning

confidence: 99%

Relationships between neuro-endocrine, electrocardiogram, and gastric mucosal damage parameters in naїve and stressed rats

Fihura,

Melnyk,

Ruzhylo

et al. 2023

J Educ Health Sport

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Introduction The first scientific publication on general adaption syndrome, or as we know today biologic stress has been published in Nature in 1936 by the 29-year old Hans Selye.1 Szabo et al2 in the anniversary review "Stress" is 80 Years Old” conclude that despite the extensive and multidisciplinary research on stress during the last 80 years, a lot of basic and clinical research is needed to better understand the manifestations, central and peripheral molecular regulators of stress response, especially the modes of prevention/management of distress or its transformation into eustress and the treatment of stress-related diseases. In the vast majority of publications on stress, the HPA-, HPG- and autonomous systems are the objects of research, while the place in the general adaptation syndrome of such important hormones as calcitonin and PTH has been studied only in a few publications. Another methodological shortcoming of most studies is that the subjects of analysis are limited to a single neuro-endocrine system. Therefore, we set ourselves the goal: to analyze relationships between some adaptation hormones, HRV, calcitonin, and PTH as well as electrocardiogram and gastric mucosal damage in naїve and post stressed rats. Material and methods Ethics approval All animals were kept in room having temperature 22±2ºC, and relative humidity of 44-55% under 12/12 hours light and dark cycle with standard laboratory diet and water given ad libitum. Studies have been conducted in accordance with the rules and requirements of the “General Principles for the Work on Animals” approved by the I National Congress on Bioethics (Kyїv, Ukraine, 2001) and agreed with the provisions of the “European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes” (Council of Europe No 123, Strasbourg 1985), and the Law of Ukraine “On the Protection of Animals from Cruelty” of 26.02.2006. The removal of animals from the experiment was carried out under light inhalation (ether) anesthesia by decapitation. Participants The experiment is at 38 rats Wistar line: 18 males (Weight Mean=227 g; SD=25 g) and 20 females (Mean=214 g; SD=27 g). Study design and procedure Due to the purposeful formation of groups, the potential predictors of post-stress reactions of the neuro-endocrine-immune complex and the metabolome3,4,5 were almost identical both in mean values and, to a lesser extent, in variance (SD). In particular, the hypoxic test (sec) was: 136±59 and 133±81; swimming test (min): 19±11 and 19±17; HRV Stress index4 (units) as (AMo/2*Mo*MxDMn)1/3: 0,14±0,08 and 0,14±0,05 in intact animals and those exposed to acute stress. Results and discussion Adhering to the algorithm of the Truskavetsian Scientific School of Balneology, we recalculated the current values of the parameters in Z-scores. This approach makes it possible to adequately compare deviations from the norm of parameters expressed in different units and with different variability.10,11,12 This is all the more important in view of sexual dimorphism in endocrine parameters. In addition to drastically higher levels of testosterone (41.8±1.7 vs 3.53±0.24 nM/L), males have higher levels of calcitonin (36±6 vs 21±4 ng/L), but lower levels of parathyroid hormone (154±12 vs 185±3 ng/L), adrenals mass (44±5 vs 65±5 mg), corticosterone (340±45 vs 466±57 nM/L), and aldosterone (587±8 vs 639±24 pM/L). Conclusion The condition of the gastric mucosa and myocardium as essential targets of stressors is determined by the damaging and protective effects of adaptive hormones and the autonomic nervous system.

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“…Elcatonin has been shown to prevent experimental ulcer formation (5,6), without any significant inhibition of histamine or bethanechol-induced acid secretion (7). Pos sible mechanisms of its action seem, there fore, to be different from that of H2-receptor antagonists or anticholinergics.…”

mentioning

confidence: 99%

Antiulcer activity of eel-calcitonin (elcatonin) is associated with enhanced gastric mucosal PGE2 generation in the rat.

Gotō

Ohno

1990

Jpn.J.Pharmacol

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Abstract-Elcatonin is a newly synthetized peptide that prevents experimental ulcer formation.In this study, we examined the influence of elcatonin on endogenous prostaglandin biosynthesis by the gastric mucosa with respect to its antiulcer ac tivity. Control levels of PGE2 generation for the fundic and antral mucosa were 302±12 and 465±28 ng/g tissue/min, respectively. Pretreatment with elcatonin resulted in a dose-dependent increment in gastric mucosal PGE2 generation. We conclude that the antiulcer effect of elcatonin is probably due to its ability to enhance endogenous prostaglandin synthesis in the gastric mucosa.

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Effect of elcatonin on experimental gastric and duodenal ulcers.

Cited by 7 publications

References 15 publications

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation

Relationships between neuro-endocrine, electrocardiogram, and gastric mucosal damage parameters in naїve and stressed rats

Antiulcer activity of eel-calcitonin (elcatonin) is associated with enhanced gastric mucosal PGE2 generation in the rat.

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