Effect of eicosapentaenoic acid on the platelet aggregation and composition of fatty acid in man A double blind study

Nagakawa, Yuzo; Orimo, Hajime; Harasawa, M; Morita, Ikuo; Yashiro, Koji; Murota, Sei‐itsu

doi:10.1016/0021-9150(83)90073-4

Cited by 96 publications

(18 citation statements)

References 12 publications

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“…The reason for this finding remains uncertain, but in some cases, poor responses can be explained by poor adherence to diet. Many studies have indicated that changes in fatty acids of dietary fat led to changes in fatty acids of serum and cell lipids, and, consequently, said studies pointed out the importance of dietary habits on the blood fatty acids composition (30)(31)(32). Therefore, we can suppose that the subjects of the HRT group and the HRT+DIET group may have progressively departed from the prescribed balanced diet, but failed to report these behavioral changes in their dietary diaries.…”

Section: Discussionmentioning

confidence: 94%

“…Also, both their plasma and platelet lipids have a similar fatty acid pattern to that found in their diet (29). Therefore, it has been suggested that a shift in dietary fatty acids composition towards the Greenland Eskimo pattern may prevent certain cardiovascular disorders, especially by reducing � the risk of thrombosis (30). In the present study, at week 4, with the changes in the dietary fat composition after the dietary fat modification, serum phospholipid (PL) P/S ratios increased by 52.4% in the DIET group, and increased by 85.0% in the HRT+DIET group (p<0.05).…”

Section: Discussionmentioning

confidence: 99%

“…The n-3 fatty acids replace some of the arachidonic acid in the platelet membranes, decreasing its availability for eicosanoid formation. As a result, less TXA2 is produced in response to activation, and the tendency for the platelets to aggregate is reduced (30,38). In this present study, at week 4, the ratios of C20:5/C20:4 in serum PL increased, but plasma TXB2 levels, metabolites of TXA2 (39), decreased by 35.0% in the DIET group (p<0.05) and decreased by 18.8% in the HRT +DIET group (NS).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB Level in Korean Postmenopausal Women with Hypercholesterolemia

et al. 2002

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The purpose of this study was to observe the effects of dietary intervention, through the modification of dietary fatty acids composition and antioxidant vitamins, on plasma thromboxane B2 (TXB2) levels in postmenopausal women with hypercholesterolemia. The subjects were treated for 12 weeks with one of three methods: hormone replacement therapy (HRT group, n=8), dietary intervention (DIET group, n=8), or HRT combined with dietary intervention (HRT+DIET group, n=8). Changes in serum phospholipid fatty acids composition, serum peroxides, and plasma TXB2 levels were measured at weeks 0, 4 and 12. The P/S ratio increased and the n-6/n-3 ratio decreased in the DIET and the HRT+DIET group at week 4 (p<0.05). The ratio of C20:5/C20:4 in serum phospholipid increased in the DIET (p<0.05) and the HRT+DIET groups (NS) at week 4. Plasma TXB2 levels decreased in the DIET (-35%, p<0.05) and the HRT+DIET groups (-18.8%, NS) at week 4. Serum lipid peroxides levels significantly decreased by 10.5% and 15.2% in the DIET group at weeks 4 and 12, and by 10.8% in the HRT+DIET group only at week 12 (p<0.05). Dietary intervention may lower thrombotic risks in Korean postmenopausal women by changing the serum fatty acid composition, serum lipid peroxides levels and plasma thromboxane B2 levels.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB Level in Korean Postmenopausal Women with Hypercholesterolemia

et al. 2002

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“…Though some studies using fish oil and other lipid-lowering regimes suggest that those patients with hyperlipidaemia might show the largest reductions of lipids, no consistent pattern was seen in our study. Previ ous studies in normal volunteers have shown similar lipid changes with an oily fish diet [25], cod liver oil [26], purified EPA [27], and MaxEPA [28], as well as reduction of in vitro platelet aggregability [25,27], The mechanism by which MaxEPA and other fish oils exert their effects on lipids is unclear. The relationship between dietary fat and platelet function has been extensively reviewed by Sanders [28].…”

Section: Discussionmentioning

confidence: 99%

Fish Oil Modifies Lipids and Reduces Platelet Aggregability in Haemodialysis Patients

Rylance

Gordge

Saynor

et al. 1986

Nephron

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Haemodialysis patients have an exceptionally high incidence of death from cardiovascular causes, related in part to abnormalities of lipids and platelets. Eskimos, however, have a low incidence of myocardial infarction and have a high dietary intake offish, rich in ω-3 polyunsaturated fatty acids. We have, therefore, studied the effect of a fish oil MaxEPA, containing 3.6 g of the ω-3 polyunsaturated fatty acid eicosapentaenoic acid on lipids and platelet function in haemodialysis patients. Following 8 weeks of therapy there was a 35% fall in triglycerides, a 10% rise of high-density lipoprotein (HDL) cholesterol, a 36% rise of HDL₂ cholesterol fraction and a 54% rise of the HDL₂:HDL₃ cholesterol ratio. The platelet aggregation to adenosine diphosphate and collagen was significantly reduced. The activated whole-blood clotting time was prolonged from 141 to 153 s, and 69% of patients showed a reduction of factor VIII related antigen which is usually elevated in haemodialysis patients and is thought to be a marker of endothelial damage. The blood pressure fell from 147/82 to 124/74. We have thus shown that a dietary supplement of eicosapentaenoic acid produces potentially beneficial effects on lipids, platelets, and blood pressure and may help to protect against atheroma and thus cardiovascular mortality in high-risk haemodialysis patients.

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“…It is well known that n-3 fatty acids decrease platelet aggregability in nontransplanted patients. 53 - 54 Because fish oil supplementation has been shown to inhibit atherosclerosis in a cyclosporine-treated heart allograft model in the rat, 55 the influence of n-3 fatty acids should be investigated further as potential agents to decrease the accelerated coronary disease of transplanted hearts.…”

Section: Platelet Aggregation Relation To Other Clinical and Biologicmentioning

confidence: 99%

Platelet function and composition in heart transplant recipients compared with nontransplanted coronary patients.

Lorgeril

Dureau

Boissonnat

et al. 1992

Arterioscler Thromb

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Accelerated coronary artery disease seems to be the main condition limiting long-term survival after heart transplantation. Ninety-one heart transplant recipients were compared with 94 nontransplanted coronary artery disease patients in an attempt to identify the factors responsible for the accelerated form of coronary artery disease occurring after heart transplantation. Among the parameters examined, heart transplant recipients exhibited a higher plasma level of insulin (8.5±0.5 versus 62±03 mIU/1, p=0.002), a lower plasma level of vitamin E (14.8±0.4 versus 16.9±0.7 mg/1, p=0.03), a higher platelet cholesterol-to-phospholipid ratio (8.9±0J versus 7.6±0«3, p=0.007), and an increased response to ADP-induced platelet aggregation (for the first wave, 29.1±0.9% of maximal aggregation versus 25.1±1.0%, />=0.002; for the second wave, 21.4±1.4% versus 15.9±1.1%, p=0.002, after adjustment for hematocrit), but no untoward changes in the level of fibrinogen, plasminogen activator inhibitor-1, antithrombin III, or lipoprotein(a). In addition, platelet aggregation in patients who required retransplantation as a result of severe coronary artery disease was similar before and after retransplantation. This suggests that severe coronary artery disease is not the cause of platelet hyperaggregability. In multiple-regression analysis, ADP-induced platelet aggregation in heart transplant recipients was significantly positively related to blood glucose (r=0.50, p<0Ml) and inversely related to n-3 fatty acids from platelet phospholipids (r=0.40,p<0.01). These results are consistent with the view that a platelet disorder associated with or responsible for the increased thrombotic tendency could play a role in the pathogenesis of the disease. However, further studies are needed to investigate the mechanism of this platelet hyperaggregability, which is possibly related to a lipid peroxidation process (low plasma vitamin E) and/or to a diabetes-associated platelet lipid disorder (high insulin level). (Arteriosclerosis and Thrombosis 1992;12:222-230)

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Effect of eicosapentaenoic acid on the platelet aggregation and composition of fatty acid in man A double blind study

Cited by 96 publications

References 12 publications

The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB Level in Korean Postmenopausal Women with Hypercholesterolemia

The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB Level in Korean Postmenopausal Women with Hypercholesterolemia

Fish Oil Modifies Lipids and Reduces Platelet Aggregability in Haemodialysis Patients

Platelet function and composition in heart transplant recipients compared with nontransplanted coronary patients.

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