Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstructive pulmonary disease: A prospective randomized controlled trial

Ogasawara, Takashi; Marui, S.; Miura, Eriko; Sugiura, Masayuki; Matsuyama, Wataru; Aoshima, Yoichiro; Kasamatsu, Norio; Ogiku, Masahito; Ikematsu, Yoshito

doi:10.1016/j.clnesp.2018.09.076

Cited by 22 publications

(16 citation statements)

References 18 publications

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“…No RCT addressing the same specific aims as the Matsuyama study has been published to date. The evidence base has grown slowly over time and there are now four published RCTs in the general area of omega-3 polyunsaturated fatty acids and COPD; two specifically investigated oral nutritional supplements that contained omega-3 polyunsaturated fatty acids with other supplements such as vitamin D in cachectic COPD patients (Calder et al 2018;van de Bool et al 2017), the third focused on COPD exacerbations (Ogasawara et al 2018) and the fourth was a feasibility study (Fulton et al 2017). It should be noted that the largest RCT (> 25,000 participants) investigating both vitamin D and fish oil alone and in combination on respiratory symptoms and acute exacerbations in COPD, is expected to be completed in November 2020 (Gold et al 2016;NCT01728571: LungVITamin D and OmegA-3 Trial (LungVITAL), n.d.).…”

Section: Case Studymentioning

confidence: 99%

Continued post-retraction citation of a fraudulent clinical trial report, 11 years after it was retracted for falsifying data

Schneider

Hill

et al. 2020

Scientometrics

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This paper presents a case study of long-term post-retraction citation to falsified clinical trial data (Matsuyama et al. in Chest 128(6):3817–3827, 2005. 10.1378/chest.128.6.3817), demonstrating problems with how the current digital library environment communicates retraction status. Eleven years after its retraction, the paper continues to be cited positively and uncritically to support a medical nutrition intervention, without mention of its 2008 retraction for falsifying data. To date no high quality clinical trials reporting on the efficacy of omega-3 fatty acids on reducing inflammatory markers have been published. Our paper uses network analysis, citation context analysis, and retraction status visibility analysis to illustrate the potential for extended propagation of misinformation over a citation network, updating and extending a case study of the first 6 years of post-retraction citation (Fulton et al. in Publications 3(1):7–26, 2015. 10.3390/publications3010017). The current study covers 148 direct citations from 2006 through 2019 and their 2542 second-generation citations and assesses retraction status visibility of the case study paper and its retraction notice on 12 digital platforms as of 2020. The retraction is not mentioned in 96% (107/112) of direct post-retraction citations for which we were able to conduct citation context analysis. Over 41% (44/107) of direct post-retraction citations that do not mention the retraction describe the case study paper in detail, giving a risk of diffusing misinformation from the case paper. We analyze 152 second-generation citations to the most recent 35 direct citations (2010–2019) that do not mention the retraction but do mention methods or results of the case paper, finding 23 possible diffusions of misinformation from these non-direct citations to the case paper. Link resolving errors from databases show a significant challenge in a reader reaching the retraction notice via a database search. Only 1/8 databases (and 1/9 database records) consistently resolved the retraction notice to its full-text correctly in our tests. Although limited to evaluation of a single case (N = 1), this work demonstrates how retracted research can continue to spread and how the current information environment contributes to this problem.

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Section: Case Studymentioning

confidence: 99%

Continued post-retraction citation of a fraudulent clinical trial report, 11 years after it was retracted for falsifying data

Schneider

Hill

et al. 2020

Scientometrics

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“…Body Mass Index (BMI) was assessed before and after using supplementation in six out of 24 studies. (23, 27, 32, 34, 36, 38) BMI significantly increased in the supplementation group when compared to the placebo group in three studies. (27, 32, 38) Three studies reported no significant difference in BMI between participants who received nutritional supplementation with PR compared to PR only.…”

Section: Resultsmentioning

confidence: 93%

“…(27, 32, 38) Three studies reported no significant difference in BMI between participants who received nutritional supplementation with PR compared to PR only. (23, 34, 36) One RCT at the lowest risk of bias showed no improvement in BMI with carnitine. (34) In contrast, Gurgun et al reported that BMI significantly increased after receiving nutritional supplement.…”

Section: Resultsmentioning

confidence: 99%

Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review

Aldhahir

Rajah

Aldabayan

et al. 2019

Preprint

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Uptake of nutritional supplementation during pulmonary rehabilitation (PR) for people with chronic obstructive pulmonary disease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. Our objective were to report and summarise the current evidence supporting use of nutritional supplementation to improve outcomes during pulmonary rehabilitation in stable COPD patients. A systematic search was conducted up to May 7th, 2019 (registration number CRD42018089142). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Six databases were included: Medical Literature Analysis and Retrieval System Online or MEDLARS Online (Medline), Allied and Complementary Medicine Database (AMED), the Cochrane Database of Systematic Reviews, Excerpta Medica dataBASE (Embase), Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Web of Science. This systematic search generated 580 initial matches, of which 24 studies (1035 COPD participants) met the pre-specified criteria and were included. Our analysis does not confirm an impact of nutritional supplementation during PR, but studies, supplements and PR programmes were heterogeneous in nature. There is currently insufficient evidence on the effect of nutritional supplementation on improving outcomes during PR in patients with COPD. Therefore, controversy remains and further research is needed.

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“…Each of the following interventions was assessed by one RCT: caloric supplement vs usual diet; 37 caloric and a protein supplement vs placebo (non-caloric fluid, vanilla flavored water); 43 and high fat low carbohydrate diet vs usual diet 42 ; and omega-3 fatty acid enriched diet vs usual diet. 32 There were no significant associations between any of the interventions and effectiveness outcomes and AEs.…”

Section: Dietary Interventionsmentioning

confidence: 84%

Nonpharmacologic Therapies in Patients With Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review With Meta-Analysis

Dobler

Morrow

Farah

et al. 2020

Mayo Clinic Proceedings

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Objective: To evaluate the effectiveness and adverse events of non-pharmacological interventions in patients with exacerbation of COPD. Patients and Methods: We searched Embase, MEDLINE, Cochrane databases, Scopus and clinicaltrials.gov from database inception to January 2, 2019, for randomized controlled trials (RCTs) that enrolled adults with exacerbation of COPD and evaluated the effect of nonpharmacological interventions on clinical outcomes and/or lung function. Results: We included 30 RCTs with 2,643 participants. Improvement in 6-minute walking distance was associated with resistance training (WMD (weighted mean difference) 74.42;

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Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstructive pulmonary disease: A prospective randomized controlled trial

Cited by 22 publications

References 18 publications

Continued post-retraction citation of a fraudulent clinical trial report, 11 years after it was retracted for falsifying data

Continued post-retraction citation of a fraudulent clinical trial report, 11 years after it was retracted for falsifying data

Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review

Nonpharmacologic Therapies in Patients With Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review With Meta-Analysis

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