Effect of Education on Alzheimer’s Disease-Related Neuroimaging Biomarkers in Healthy Controls, and Participants with Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-Sectional Study

Wada, Masataka; Noda, Yoshihiro; Shinagawa, Shunichiro; Chung, Jun Ku; Sawada, Kyosuke; Ogyu, Kamiyu; Tarumi, Ryosuke; Tsugawa, Sakiko; Miyazaki, Takahiro; Yamagata, Bun; Graff‐Guerrero, Ariel; Mimura, Masaru; Nakajima, Shinichiro

doi:10.3233/jad-171168

Cited by 37 publications

(23 citation statements)

References 24 publications

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“…Studies have shown that good education and cultural background have a positive effect on the ability of concept formation, vocabulary expression, spatial structure perception and memory, while cultural restriction may contribute to a negative effect [40]. Highly educated people often have a high reserve of neurons [41]. The more people receive education, the better subjective initiative and ability to adapt to the external environment, which may stimulate brain cells [42].…”

Section: Clinical Risk Factors For Preoperative Cognitive Impairmentmentioning

confidence: 99%

Preoperative assessment of cognitive function and risk assessment of cognitive impairment in elderly patients with orthopedics: a cross-sectional study

Gan

et al. 2020

BMC Anesthesiol

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Background: Preexisting cognitive impairment is emerging as a predictor of poor postoperative outcomes in seniors. Nevertheless, cognitive impairment in a large proportion of geriatric patients has not been well identified and diagnosed. Methods: This is a cross-sectional study. Mini-mental state examination scale was used to assess the cognitive function of elderly patients aged ≥65 years undergoing orthopedic surgery preoperatively. The baseline, living habits and laboratory examination results of two groups were compared, and a multivariable logistic regression model was used to identify independent predictors of preoperative cognitive impairment. Results: A total of 374 elderly patients with orthopedic surgery indications met the inclusion criteria, and 28.61% of them had preoperative cognitive impairment. Multivariable logistic regression analysis showed that age (OR = 1.089, P < 0.001), subjective sleep disorders (OR = 1.996, P = 0.021), atherosclerosis (OR = 2.367, P = 0.017), and high cholesterol level (OR = 1.373, P = 0.028) were independent risk factors for preoperative cognitive impairment, while high education level performed as a protective factor (compared with the illiterate group, primary school group: OR = 0.413, P = 0.009; middle school or above group: OR = 0.120, P < 0.001). Conclusions: The prevalence of preoperative cognitive dysfunction in geriatric elective orthopedic surgical patients was high. Our study identified venerable age, low level of education, subjective sleep disorders, atherosclerosis, and high cholesterol level as risk factors for preoperative cognitive impairment in these patients. Understanding these risk factors contributes to assisting in prevention and directed interventions for the high-risk population.

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Section: Clinical Risk Factors For Preoperative Cognitive Impairmentmentioning

confidence: 99%

Preoperative assessment of cognitive function and risk assessment of cognitive impairment in elderly patients with orthopedics: a cross-sectional study

Gan

et al. 2020

BMC Anesthesiol

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“…The evidence regarding the association between education and amyloid deposition has been more limited. A recent study using data from the Alzheimer’s Disease Neuroimaging Initiative found that education duration was not correlated with amyloid deposition[5]. Additionally, findings from the Epidemiological Clinicopathological Studies in Europe (EClipSE)[6] showed education was associated with lower likelihood of dementia at death and greater brain volume, but not associated to neurodegeneration or vascular pathologies.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Rawlings

Sharrett

Mosley

et al. 2019

JAD

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We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography(PET). We used data from the Atherosclerosis Risk in Communities(ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR)>1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer’s Disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

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“…Interestingly, this pattern was distinct from the sex effect, which was found in the head of the hippocampus, in which inward displacement was associated with low education and female sex. Education has often been considered an influential factor in cognitive performance and hippocampal volume or microstructure (Piras et al 2011) as well as a protective factor against mild cognitive impairment (Wada et al 2018) and AD dementia (Meng and D’Arcy 2012; Groot et al 2018). Gender inequality with regards to education is predictable since older women from our datasets were born in a socioeconomic period when they were less encouraged to pursue higher education than men (Permanyer and Boertien 2019).…”

Section: Discussionmentioning

confidence: 99%

Hippocampus shape across the healthy lifespan and its relationship with cognition

Bussy

Plitman

Tullo

et al. 2020

Preprint

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The study of the hippocampus across the healthy adult lifespan has rendered inconsistent findings. While volumetric measurements have often been a popular technique for analysis, more advanced morphometric techniques have demonstrated compelling results that highlight the importance and improved specificity of shape-based measures. Here, the MAGeT Brain algorithm was applied on 134 healthy individuals aged 18-81 years old to extract hippocampal subfield volumes and hippocampal shape measurements, notably : local surface area (SA) and displacement. We used linear, second or third order natural splines to examine the relationships between hippocampal measures and age. In addition, partial least squares analyses were performed to relate measurements with cognitive and demographic information. Volumetric results indicated a relative preservation of the right cornus ammonis 1 with age and a global volume reduction linked with older age, female sex, lower levels of education and cognitive performance. Vertex-wise analysis demonstrated an SA preservation in the anterior hippocampus with a peak during the sixth decade, while the posterior hippocampal SA gradually decreased across lifespan. Overall, SA decrease was linked to older age, female sex and, to a lesser extent lower levels of education and cognitive performance. Outward displacement in the lateral hippocampus and inward displacement in the medial hippocampus were enlarged with older age, lower levels of cognition and education, indicating an accentuation of the hippocampal C shape with age. Taken together, our findings suggest that vertex-wise analyses have higher spatial specifity and that sex, education and cognition are implicated in the differential impact of age on hippocampal subregions throughout its antero-posterior and medial-lateral axes.

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Effect of Education on Alzheimer’s Disease-Related Neuroimaging Biomarkers in Healthy Controls, and Participants with Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-Sectional Study

Abstract: Our findings suggest that education may exert a protective effect on total brain volume in the MCI stage but not in HC or AD. Thus, education may play an important role in preventing the onset of dementia through brain reserve in MCI.

Cited by 37 publications

References 24 publications

Preoperative assessment of cognitive function and risk assessment of cognitive impairment in elderly patients with orthopedics: a cross-sectional study

Preoperative assessment of cognitive function and risk assessment of cognitive impairment in elderly patients with orthopedics: a cross-sectional study

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Hippocampus shape across the healthy lifespan and its relationship with cognition

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