Effect of (—)Eburnamonine, Papaverine and UDP-Glucose on Cerebral Energy State during and after Experimental Hypoxia and Ischaemia in Beagle Dog

Abstract

The effect of (—)eburnamonine, papaverine and UDP-glucose intracarotid perfusion has been evaluated in the brain of beagle dogs during various conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischaemia, hypoxia plus complete ischaemia), and after 3, 15 or 30 min of the post-hypoxic recovery and recirculation. The behaviour of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), of the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge potential of the brain were evaluated in the motor area of the cerebral cortex. The different pharmacological effects of (—)eburnamonine, papaverine and UDP-glucose are discussed with regard to the biochemical changes taking place during the physiopathological conditions tested.

Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles

“…Dihydropyrido [1,2-a]indolone (DHPI) skeletons are commonly found in natural products and pharmaceutical compounds (Figure 1) [1][2][3], which exhibit a wide range of biological and pharmaceutical activities [4]. For example, mersicarpine has been found to inhibit protein translation and induce apoptosis [5] and vinburnine acts as a vasodilator for the treatment of cerebrovascular insufficiency [6,7].…”

Experimental Clinical Studies on the Effect of Eburnamonine in Cerebrovascular Disorders

“…Eburnamonine or vincamone (empirical forrnula C l9 H22N02) is structurally similar to vincamine, vincanol and vinpocetine. In various species and under various hypoxie conditions Eburnamonine exerts an antihypoxic activity (Linnee et al, 1977, Villa et al, 1978. Pharrnacological studies have shown that Eburnamonine improves cerebral circulation and cerebral metabolism more effectively and for a longer time than vincamine (Laeroix et al, 1979;Linnee et al, 1980).…”