Effect of eating on colonic motility and transit in patients with functional diarrhea

Bazzocchi, Gabriele; Ellis, Jonathan; Villanueva‐Meyer, Javier; Reddy, S. N.; Mena, I; Snape, William J.

doi:10.1016/0016-5085(91)90080-5

Cited by 99 publications

(82 citation statements)

References 25 publications

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“…The accelerated transit of colonic contents in these patients may result in increased stool water due to diminished contact time of the luminal contents with the colonic mucosa (27,28). The numbers of fasting-and postprandial-propagated contractions of the colon were increased in patients with diarrhea compared with results in healthy subjects (3).…”

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confidence: 64%

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Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Nakade¹,

Fukuda²,

Iwa³

et al. 2007

American Journal of Physiology-Gastrointestinal and Liver Physi

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Although restraint stress accelerates colonic transit via a central corticotropin-releasing factor (CRF), the precise mechanism still remains unclear. We tested the hypothesis that restraint stress and central CRF stimulate colonic motility and transit via a vagal pathway and 5-HT3 receptors of the proximal colon in rats. 51Cr was injected via the catheter positioned in the proximal colon to measure colonic transit. The rats were subjected to a restraint stress for 90 min or received intracisternal injection of CRF. Ninety minutes after the administration of 51Cr, the entire colon was removed, and the geometric center (GC) was calculated. Four force transducers were sutured on the proximal, mid, and distal colon to record colonic motility. Restraint stress accelerated colonic transit (GC of 6.7 ± 0.4, n = 6) compared with nonrestraint controls (GC of 5.1 ± 0.2, n = 6). Intracisternal injection of CRF (1.0 μg) also accelerated colonic transit (GC of 7.0 ± 0.2, n = 6) compared with saline-injected group (GC of 4.6 ± 0.5, n = 6). Restraint stress-induced acceleration of colonic transit was reduced by perivagal capsaicin treatment. Intracisternal injection of CRF antagonists (10 μg astressin) abolished restraint stress-induced acceleration of colonic transit. Stimulated colonic transit and motility induced by restraint stress and CRF were significantly reduced by the intraluminal administration of 5-HT3 antagonist ondansetron (5 × 10−6 M; 1 ml) into the proximal colon. Restraint stress and intracisternal injection of CRF significantly increased the luminal content of 5-HT of the proximal colon. It is suggested that restraint stress stimulates colonic motility via central CRF and peripheral 5-HT3 receptors in conscious rats.

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confidence: 64%

“…It has been suggested that the primary alteration of mucosal absorption and secretion may not contribute to the frequent stools in patients with functional diarrhea (3). The accelerated transit of colonic contents in these patients may result in increased stool water due to diminished contact time of the luminal contents with the colonic mucosa (27,28).…”

mentioning

confidence: 99%

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Nakade¹,

Fukuda²,

Iwa³

et al. 2007

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Colonic propagating contractions with high amplitude and long duration are referred to as giant migrating con tractions (GMCs), which are closely associated with the provocation of urgency and defecation (1,2). Recently, Bazzocchi et al, using both the manometric and the scinti graphic method simultaneously, demonstrated that these colonic contractions are the motor equivalents of colonic peristalsis or the rapid and massive movements of the colonic contents (2).…”

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confidence: 99%

“…Recently, Bazzocchi et al, using both the manometric and the scinti graphic method simultaneously, demonstrated that these colonic contractions are the motor equivalents of colonic peristalsis or the rapid and massive movements of the colonic contents (2). On the other hand, glycerol enema that is clinically used for the treatment of chronic consti pation (3) or paralytic ileus (4) has been known to induce GMCs (5)(6)(7).…”

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confidence: 99%

Colonic Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats

Tomaru

Ishii

Kishibayashi

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-Colonic motility was measured with three catheter pressure transducers that were inserted into the descending colon at the distance of 4 cm, 6 cm and 8 cm from the anal verge in anesthetized rats. Colonic infusion of glycerol (65%, 2 ml/kg) induced large phasic pressure changes with high amplitude and long duration. Some of the pressure changes propagated over all the three recording sites, appearing to be equivalent to giant migrating contractions. These glycerol-induced large propulsions were abolished by lido caine (5%, 2 ml/kg, intracolon), hexamethonium (10 mg/kg, i.v.) or clonidine (30 pg/kg, i.v.); and they were almost entirely suppressed by atropine (3 mg/kg, i.v.), suggesting the principal involvement of the cholinergic neural pathway.

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“…Diarrhea also occurs as a Ogata/Shibata consequence of abnormal motility of intestine [1,9,10]. For instance, hypermotility of the intestine is found in some types of functional diarrheas, such as irritable bowel syndrome [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Activity of Wood Creosote: Inhibition of Muscle Contraction and Enterotoxin-Induced Fluid Secretion in Rabbit Small Intestine

Ogata¹,

Shibata²

2001

Pharmacology

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Wood creosote has long been used as an antidiarrheal agent, but its mechanism of action is not well understood. To elucidate the mechanism of its antidiarrheal activity, we have addressed questions whether it inhibits fluid secretion induced by Escherichia coli heat-stable enterotoxin (STa) in rabbit jejunum in vivo, and whether it inhibits muscle contraction of isolated rabbit ileum ex vivo. Wood creosote (10–100 mg/l) instilled in a ligated loop of jejunum inhibited STa-induced fluid secretion (p < 0.05). It also inhibited the spontaneous phasic, acetylcholine-induced tonic and Ba²⁺-induced tonic contractions of longitudinal and circular muscles of ileum dose-dependently with IC₅₀ values of 130–530 mg/l. These data provide further evidence that the antidiarrheal activity of wood creosote is attributable to its antisecretory and antimotility effects.

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Effect of eating on colonic motility and transit in patients with functional diarrhea

Cited by 99 publications

References 25 publications

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Colonic Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats

Antidiarrheal Activity of Wood Creosote: Inhibition of Muscle Contraction and Enterotoxin-Induced Fluid Secretion in Rabbit Small Intestine

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Effect of eating on colonic motility and transit in patients with functional diarrhea

Cited by 99 publications

References 25 publications

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats

Colonic Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats

Antidiarrheal Activity of Wood Creosote: Inhibition of Muscle Contraction and Enterotoxin-Induced Fluid Secretion in Rabbit Small Intestine

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Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT₃ receptors in conscious rats