2010
DOI: 10.1161/atvbaha.110.215350
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Effect of Early Particulate Air Pollution Exposure on Obesity in Mice

Abstract: Objective To evaluate the role of early-life exposure to airborne fine particulate matter (diameter, <2.5 µm [PM2.5]) pollution on metabolic parameters, inflammation, and adiposity; and to investigate the involvement of oxidative stress pathways in the development of metabolic abnormalities. Methods and Results PM2.5 inhalation exposure (6 h/d, 5 d/wk) was performed in C57BL/6 mice (wild type) and mice deficient in the cytosolic subunit of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p47ph… Show more

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Cited by 265 publications
(231 citation statements)
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“…Much of the research conducted for chemical responses employs animal studies, where outcomes and trans-generational responses can be observed in a relatively short period of time. 127,147,148,[174][175][176] Based on the selection scheme detailed in this paper's methodology, only 33% of the studies included in the literature review considered environmental chemical exposures that were not a consequence of prenatal cigarette smoke exposure or physicianprescribed medications. The most common chemical exposures included perfluorinated compounds, phthalates, and outdoor air pollution.…”
Section: Discussionmentioning
confidence: 99%
“…Much of the research conducted for chemical responses employs animal studies, where outcomes and trans-generational responses can be observed in a relatively short period of time. 127,147,148,[174][175][176] Based on the selection scheme detailed in this paper's methodology, only 33% of the studies included in the literature review considered environmental chemical exposures that were not a consequence of prenatal cigarette smoke exposure or physicianprescribed medications. The most common chemical exposures included perfluorinated compounds, phthalates, and outdoor air pollution.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, less is known with regard to the role of NOX2 in adipogenesis and obesity. One report suggested that male mice with inactive NOX2 as a result of p47 phox deficiency are protected against high fatinduced adipose tissue inflammation and systemic insulin resistance (43). Another recent study linked induction of p47phox mRNA expression in differentiated adipocytes in vitro by the obesity-associated ETS transcription factor PU.1 with ROS generation, activation of the MAP kinase JNK, and inhibition of insulin signaling and cytokine production (23).…”
mentioning
confidence: 99%
“…Immunohistochemical staining was performed as previously described. 36,37 The slices were stained with mouse anti-human nuclei (Catalog No. MAB1281, Merck Millipore).…”
Section: Assessment Of Lung Injurymentioning
confidence: 99%