Effect of early body weight and moderate dietary restriction on the survival of the sprague-dawley rat

Laroque, Philippe; Kp, Keenan; Ka, Soper; Dorian, C; Gerin, G; Hoe, CM; Duprat, Pierre

doi:10.1016/s0940-2993(97)80135-2

Cited by 25 publications

(24 citation statements)

References 21 publications

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“…Similar carefully balanced studies in Fischer 344 rats with the restriction of dietary fat or minerals without caloric restriction demonstrate no survival benefit (Maeda et al, 1985;Masoro et al, 1991). Studies with Sprague-Dawley rats and Wistar rats fed diets with modified protein and fiber content have led to similar conclusions, since these modifications did not improve survival if the animals were allowed AL food intake (Gumprecht et al, 1993;Keenan et al, 1992Keenan et al, , 1994aKeenan et al, , 1994bKeenan et al, , 1995aKeenan et al, , 1995bKeenan et al, , 1996Keenan et al, , 1997Laroque et al, 1997;Roeetal., 1995).…”

Section: Control Of Specific Nutrients and Contaminantsmentioning

confidence: 90%

“…Control rodent survival at 24 mo during the 1980s and 1990s has become highly variable Hart et al, 1995;Haseman & Rao, 1992;Keenan et al, 1992Keenan et al, , 1994aKeenan et al, , 1994bKeenan et al, , 1995aKeenan et al, , 1995bKeenan et al, , 1996Keenan et al, , 1997Lang, 1991;Laroque et al, 1997;Rao et al, 1990;Roe, 1994;Turturro et al, 1995Turturro et al, , 1996. For example, male Sprague-Dawley rat survival ranged from 7 to 73%, male Fischer 344 rats from 36 to 85%, male CD-I mice from 20 to 80%, and male B6C3F1 mice from 40 to 97% Haseman & Rao 1992;Keenan et al, 1994b;Lang, 1991;Rao et al, 1990;Turturro et al, 1995Turturro et al, , 1996.…”

Section: Decreased Survivalmentioning

confidence: 99%

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Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies

Keenan

Laroque

Dixit

1998

Journal of Toxicology and Environmental Health, Part B

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The conditions under which laboratory animals are maintained can powerfully influence the results of toxicological studies utilized for risk assessment. Nutrition is of importance in toxicological bioassays and research, because diet composition and the conditions under which it is fed can affect the metabolism and activity of xenobiotic test substances and alter the results and reproducibility of long-term studies. It is known that ad libitum (AL) overfed sedentary laboratory rodents suffer from an early onset of degenerative disease and diet-related tumors that lead to poor survival in chronic bioassays. AL-fed animals are not well-controlled subjects for any experimental studies. Examination of study-to-study variability in food consumption, body weight, and survival in carcinogenicity studies for the same strain or stock of rodents shows tremendous laboratory-to-laboratory variability. However, a significant correlation between average food (calorie) consumption, adult body weight, and survival has been clearly established. The use of moderate dietary restriction (DR) results in a better controlled rodent model with a lower incidence or delayed onset of spontaneous diseases and tumors. Operationally simple, moderate DR significantly improves survival, controls adult body weight and obesity, reduces age-related renal, endocrine, and cardiac diseases, increases exposure time, and increases the statistical sensitivity of these expensive, chronic bioassays to detect a true treatment effect. A moderate DR regimen of 70-75% of the maximum unrestricted AL food intake is recommended as a nutritionally intelligent, well-established method in conducting well-controlled toxicology and carcinogenicity studies.

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Section: Control Of Specific Nutrients and Contaminantsmentioning

confidence: 90%

Section: Decreased Survivalmentioning

confidence: 99%

Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies

Keenan

Laroque

Dixit

1998

Journal of Toxicology and Environmental Health, Part B

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“…The most poorly controlled variable in rodent bioassays is excessive ad libitum (AL) food (caloric) intake (24)(25)(26)(27)(28)32). It is also the main cause of early development of spontaneous tumors and severe degenerative diseases, resulting in poor 2-year survival (4, 21, 26-28, 32, 46, 51).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague—Dawley Rats

et al. 2001

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This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on aged-related degenerative and proliferative changes of the endocrine pancreas in Sprague-Dawley (SD) rats. SD rats were fed Purina Certi ed Rodent Diet AL (group 1), DR at 72-79% of AL (group 2), DR at 68-72% of AL (group 3) or DR at 47-48% of AL (group 4) for 106 weeks. Interim necropsies were performed at 13, 26, and 53 weeks, after a 7-day 5-bromo-2-deoxyuridin e (BrdU)-lled minipump implantation. Before each necropsy, glucose and serum insulin levels were measured. In addition to the routine histopathologi c examination performed in both sexes, determination of 9 pancreatic islet stereologic parameters was done in males at 13, 26, and 53 weeks. In AL-fed rats, early changes in the islet morphology occurred, which resulted in a high incidence of islet brosis, focal hyperplasias and adenomas by two years. DR was dose-proportionall y associated with decreased glucose and serum insulin levels, and delayed the onset, and decreased the incidence and severity of islet brosis and hyperplasia. Results of the stereology supported the histopathologi c and clinical chemistry ndings. It demonstrated that, compared to AL-fed rats, DR-fed rats had smaller pancreas, smaller pancreatic islets, smaller insulin secreting cell volumes, a lower degree of islet brosis and a lower islet cell BrdU labeling index, which correlated with a lower incidence of islet adenoma and carcinoma at study termination. Moderate and marked degrees of DR delayed the onset and severity of islet hyperplasia and brosis in a temporal-and dose-related manner. In contrast to marked DR, which dramatically prevented these changes, moderate DR delayed but not prevented onset of islet tumors. These ndings support the concept that moderate DR results in a better-controlled animal model with a lower incidence or delayed onset of chronic spontaneou s endocrine diseases in the rat bioassay.

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“…Spontaneous chronic nephropathy is the most common non-neoplastic cause of death in 2-year studies with F344 rats and various stocks of Wistar and SD rats AL-fed a variety of diets (17,24,29,42,43). Early unscheduled deaths from nephropathy complicate survival-adjusted statistical analyses of tumors and modify the context of observations used in those statistical evaluations (17,23,25).…”

Section: Introductionmentioning

confidence: 99%

Chronic Nephropathy in Ad Libitum Overfed Sprague-Dawley Rats and Its Early Attenuation by Increasing Degrees of Dietary (Caloric) Restriction to Control Growth

et al. 2000

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Effect of early body weight and moderate dietary restriction on the survival of the sprague-dawley rat

Cited by 25 publications

References 21 publications

Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies

Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague—Dawley Rats

Chronic Nephropathy in Ad Libitum Overfed Sprague-Dawley Rats and Its Early Attenuation by Increasing Degrees of Dietary (Caloric) Restriction to Control Growth

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