Effect of e-Cigarette Use on Cough Reflex Sensitivity

Dicpinigaitis, Peter V.; Chang, Alfredo Lee; Dicpinigaitis, Alis J.; Negassa, Abdissa

doi:10.1378/chest.15-0817

Cited by 63 publications

(45 citation statements)

References 32 publications

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“…A recent study recruited 30 healthy never smokers and carried out baseline cough reflex sensitivity testing with capsaicin challenge, followed the next day by inhaling 30 puffs from a disposable e-cig (Blu, Classic Tobacco flavor, estimated 1.5-1.8 mg nicotine in 30 puffs). At 15 min postvaping, cough reflex sensitivity was significantly reduced, recovering to baseline levels 24 h later (34). Interestingly, the reduction in cough reflex sensitivity appears to be nicotine dependent, since nonnicotine-containing e-cigs had no effect.…”

Section: Respiratory Physiologymentioning

confidence: 89%

Pulmonary toxicity of e-cigarettes

Chun

Moazed

Calfee

et al. 2017

American Journal of Physiology-Lung Cellular and Molecular Phys

249

211

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Electronic cigarettes (e-cigarettes or e-cigs) are designed to heat and aerosolize mixtures of vegetable glycerin, propylene glycol, nicotine, and flavoring additives, thus delivering nicotine by inhalation in the absence of combustion. These devices were originally developed to facilitate smoking cessation and have been available in the United States for over a decade. Since 2010, e-cig use has expanded rapidly, especially among adolescents, despite a paucity of short- and long-term safety data. Patterns of use have shifted to include never smokers and many dual users of e-cigs and combustible tobacco products. Over the last several years, research into the potential toxicities of e-cig aerosols has grown exponentially. In the interim, regulatory policymakers across the world have struggled with how to regulate an increasingly diverse array of suppliers and products, against a backdrop of strong advocacy from users, manufacturers, and tobacco control experts. Herein we provide an updated review of the pulmonary toxicity profile of these devices, summarizing evidence from cell culture, animal models, and human subjects. We highlight the major gaps in our current understanding, emphasize the challenges confronting the scientific and regulatory communities, and identify areas that require more research in this important and rapidly evolving field.

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Section: Respiratory Physiologymentioning

confidence: 89%

Pulmonary toxicity of e-cigarettes

Chun

Moazed

Calfee

et al. 2017

American Journal of Physiology-Lung Cellular and Molecular Phys

249

211

View full text Add to dashboard Cite

show abstract

“…In general, there is a reduction in the respiratory symptoms of chronic cough, chronic phlegm production, wheezing and shortness of breath following smoking cessation (Gillissen 2011). Recent studies suggest that a single exposure to an ecigarette (nicotine vapour) can enhance the cough reflex which is suppressed in otherwise healthy cigarette smokers (Dicpinigaitis et al 2016).…”

Section: Wheeze Cough and Sputum (W/c/s)mentioning

confidence: 99%

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

Peck

Sanders²,

Scherer

et al. 2018

Biomarkers

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“…The most common acute adverse effects due to EC use were irritation of the respiratory tract (including the mouth and throat), dry throat, cough, and cough reflex suppression (Nides et al 2014;D'Ruiz et al 2015;Salturk et al 2015;Dicpinigaitis et al 2016a;Walele et al 2016). These effects are probably due to the propylene glycol discussed earlier, which is a component of the EC liquid and is a known respiratory irritant.…”

Section: Acute Adverse Effects Caused By Ec Usementioning

confidence: 96%

Electronic cigarettes—A review of the physiological health effects

Zucchet

Schmaltz

2017

FACETS

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Electronic cigarettes (ECs) are devices that are used recreationally or as smoking cessation tools, and have become increasingly popular in recent years. We conducted a review of the available literature to determine the health effects caused by the use of these devices. A heating element in the EC aerosolizes a solution of propylene glycol, glycerol, nicotine (optional), and flavouring (optional). These compounds are generally harmless on their own. However, upon heating, they produce various carcinogens and irritants. We found that concentrations of these toxicants vary significantly depending on the type of EC device, the type of EC liquid, and the smoking behaviour of the user. Exposure to these vapours can cause inflammation and oxidative damage to in vitro and in vivo cells. EC aerosol can also potentially affect organ systems and especially cardiovascular and lung function. We concluded that EC use causes acute effects on health but not as severe as those of conventional cigarettes (CCs). These devices could, therefore, be of use for smokers of CCs wishing to quit. However, as EC aerosol introduces new toxicants not found in CCs, long-term studies are needed to investigate possible chronic effects associated with EC use.

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Effect of e-Cigarette Use on Cough Reflex Sensitivity

Cited by 63 publications

References 32 publications

Pulmonary toxicity of e-cigarettes

Pulmonary toxicity of e-cigarettes

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

Electronic cigarettes—A review of the physiological health effects

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