Effect of duration of diabetes mellitus type 1 in children and adolescents on urinary N-acetyl-B-D-glucosaminidase excretion

Matica, Jasminka; Rački-Čargonja, Višnja; Dvornik, Štefica

doi:10.11613/bm.2006.007

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“…9,[30][31][32] Studies have shown that u-NAG excretion increases even before microalbuminuria commences. 32,33 However in the present study, u-NAG activity was found to increase in parallel with MA, which is evident from significant positive correlation between NAG and MA. Our finding is in agreement with that reported by Cohen-Bucay A et al 34 The location and function of the brush-border membrane make it a good target for the primary involvement in the pathogenesis of diabetic renal complications.…”

Section: Discussioncontrasting

confidence: 64%

Urinary brush border enzymes for early diagnosis of tubular dysfunction in patients with type 2 diabetes mellitus

2019

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Background: Diabetic nephropathy is a major cause of premature morbidity and mortality in type 1 and type 2 diabetes mellitus (T2DM) and hence new markers with better sensitivities are being investigated. The study was taken up to investigate whether urinary activities of N-acetyl-β-D-glycosaminidase (NAG), alkaline phosphatase (ALP), lactate dehydrogenase LDH) and Gamma glutamyl transferase (γ-GT) can be used as screening markers of renal dysfunction in patients suffering from T2DM.Methods: One hundred and four patients with T2DM along with 30 age- and gender-matched healthy individuals were included in the study. Patients were divided into three groups based on their u-MA levels i.e. normoalbuminuric (group1), micro albuminuric (group 2) and macroalbuminuric (group 3).Results: Urinary enzymes activity was significantly higher in patients with T2DM compared to controls (p<0.05). NAG, ALP, LDH, and GGT were significantly higher in group 3 compared to group1 and group 2 (p<0.0001). NAG, ALP, LDH and GGT showed significant positive correlation with MA (p=0.0001, r=0.308; p=0.0001, r=0.369; p=0.002, r=0.304, p=0.044, r=0.202 respectively). GGT and LDH showed highest sensitivity (86.21%, 84.00% respectively) and specificity (78.57%,53.49% respectively) for diagnosing renal dysfunction in patients with normoalbuminuria.Conclusions: The study suggests that u-GGT and LDH can be useful markers for assessing renal dysfunction in T2DM patients even before microalbuminuria manifests.

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Section: Discussioncontrasting

confidence: 64%

Urinary brush border enzymes for early diagnosis of tubular dysfunction in patients with type 2 diabetes mellitus

2019

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Effect of duration of diabetes mellitus type 1 in children and adolescents on urinary N-acetyl-B-D-glucosaminidase excretion

Abstract: Jas min ka Ma ti ca, Viš nja Rač ki-Čar go nja, Šte fi ca Dvor nik KBC Ri je ka, Za vod za la bo ra to rij sku di jag nos ti ku, Ri je ka Uni ver si ty Hos pi tal Cen tre Ri je ka, De par tme nt of La bo ra to ry Diag nos ti cs, Ri je ka, Croa tia

Cited by 1 publication

References 2 publications

Urinary brush border enzymes for early diagnosis of tubular dysfunction in patients with type 2 diabetes mellitus

Urinary brush border enzymes for early diagnosis of tubular dysfunction in patients with type 2 diabetes mellitus

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