Effect of Duloxetine on Opioid Use and Pain After Total Knee Arthroplasty: A Triple-Blinded Randomized Controlled Trial

YaDeau, Jacques T.; Mayman, David J.; Jules-Elysée, Kethy M.; Lin, Yi Hsin; Padgett, Douglas E.; DeMeo, Danya; Gbaje, Ejiro; Goytizolo, Enrique A.; Kim, David H.; Sculco, Thomas P.; Kahn, Richard L.; Haskins, Stephen C.; Brummett, Chad M.; Zhong, Haoyan; Westrich, Geoffrey H.

doi:10.1016/j.arth.2022.02.022

Cited by 21 publications

(65 citation statements)

References 11 publications

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“…Qualitative review of outcome data demonstrated a high degree of heterogeneity, variable success, and robust safety profile. Most notably, among the studies that specified their primary outcome (ie, trial registration or published protocol), only 3 studies fully achieved their primary aim [ 17 , 25 , 26 ]. A fourth study was partially successful [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…[ 10 ], which found lower postoperative opioid use with duloxetine at 24 and 48 hours in patients undergoing elective orthopaedic surgery. The nonsignificant difference in 24-hour opioid use in this meta-analysis is due to the inclusion of unpublished data from a recently published study [ 26 ]. The safety data and lack of severe adverse events observed presently is also consistent with other reviews, which have shown that duloxetine is generally safe and well-tolerated, with few serious side effects reported, particularly at doses not exceeding 60 mg/d [ [27] , [28] , [29] , [30] ].…”

Section: Discussionmentioning

confidence: 99%

“…Further support for the importance of dosing schedule comes from the largest study included in this review [ 26 ]. Patients were given a 60-mg dose for 14 days starting on POD 0.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, YaDeau et al. [ 26 ] dosed patients for 14 days after surgery and found significant improvements in opioid consumption. The apparent difference suggests that managing pain in the postoperative period may be more important than in the preoperative period for limiting pain sensitization.…”

Section: Discussionmentioning

confidence: 99%

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Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

Jones¹,

Talehakimi²,

Murphy³

et al. 2023

Arthroplasty Today

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Further support for the importance of dosing schedule comes from the largest study included in this review [ 26 ]. Patients were given a 60-mg dose for 14 days starting on POD 0.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

Jones¹,

Talehakimi²,

Murphy³

et al. 2023

Arthroplasty Today

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“…Meta-analysis of VAS at movement. Six studies [6,12,[26][27][28][29] including 517 patients reported VAS at postoperative 24 hours, and compared with the control group, the duloxetine group reduced VAS (MD = −1.22; 95% CI, [−2.12-−0.32]; P < .05. Fig.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials

Zhang

Fang

et al. 2023

Medicine

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Background: Postoperative pain is one of the most feared complications of total knee arthroplasty. Recently, randomized controlled trials have compared the efficacy of duloxetine in patients undergoing total knee arthroplasty. However, there is no definite answer as to the efficacy and safety of duloxetine. Methods: Randomized controlled trials about relevant studies were searched from PubMed (1996 to July 2022), Embase (1996 to July 2022), and Cochrane Library (CENTRAL, July 2022). Results: Six high-quality studies containing 532 patients met the inclusion criteria. Results show patients in the duloxetine group had better performance in terms of visual analog scale (P < .05), equivalent morphine consumption (P < .05), and length of stay (P < .05). Conclusion: Duloxetine can be used to reduce pain after knee arthroplasty in selected patients.

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Effect of duloxetine on pain and opioid consumption after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials

Zhong¹,

Li²,

Chen³

et al. 2023

Int J Clin Pharm

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Effect of Duloxetine on Opioid Use and Pain After Total Knee Arthroplasty: A Triple-Blinded Randomized Controlled Trial

Cited by 21 publications

References 11 publications

Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials

Effect of duloxetine on pain and opioid consumption after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials

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