Effect of dual-task training on cognitive functions in persons with multiple sclerosis: A systematic review and meta-analysis

Abasıyanık, Zuhal; Kahraman, Turhan

doi:10.1016/j.msard.2022.103801

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…This statement is in accordance with the recent findings of a meta-analysis reporting that pwMS benefit from mobility-cognitive DT training which improved gait and cognitive functions. 66 Importantly, the clinical implications mentioned in this section are not only relevant for pwMS, but, also for older adults and others with neurological impairments ( e.g. stroke, Parkinson’s disease) suffering from walking and/or cognitive difficulties.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal hemodynamics during forward and backward walking, with and without a cognitive task, in people with multiple sclerosis

Kupchenko¹,

Dreyer-Alster²,

Broscheid³

et al. 2023

Eur J Phys Rehabil Med

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BACKGROUND Hemodynamics in the prefrontal cortex (PFC) while walking forward and backward, with and without an additional cognitive task (motor single-task [ST] and motor cognitive dual-task [DT]) have not been studied in people with multiple sclerosis (pwMS). AIM To investigate the PFC hemodynamics during forward and as well as backward walking, with and without a cognitive task, in pwMS and healthy controls. DESIGN Observational case-control study SETTING Sheba Multiple Sclerosis Center, Tel-Hashomer, Israel. POPULATION Eighteen pwMS (36.1±11.7 years, 66.6% female) and 17 healthy controls (37.5±13.8 years, 76.5% female). METHODS Each subject completed four walking trials: ST forward walking, DT forward walking, ST backward walking, DT backward walking. PFC activity for all trials was recorded using functional near-infrared spectroscopy (fNIRS). The PFC was subdivided in the frontal eye field (FEF), frontopolar cortex (FPC) and the dorsolateral PFC (DLPFC). RESULTS The relative oxygenated hemoglobin (HbO) concentration was higher during the DT forward walking in all PFC subareas compared with the ST forward walking for both groups. The relative HbO concentration was higher during ST backward walking compared with ST forward walking in pwMS (DLPFC, FEF) and the healthy controls (FEF, FPC), specifically during the initial part of the trial. CONCLUSIONS ST backward walking and DT forward walking impact the hemodynamics at the PFC, although, the difference between pwMS and healthy adults requires further clarification. Future RCT’s are encouraged to examine the impact of an intervention program based on DT forward and backward walking on PFC activity in pwMS. CLINICAL REHABILITATION IMPACT Backward walking increases activity in the PFC region in pwMS. Similarly, when performing a cognitive task while walking forward.

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Section: Discussionmentioning

confidence: 99%

Prefrontal hemodynamics during forward and backward walking, with and without a cognitive task, in people with multiple sclerosis

Kupchenko¹,

Dreyer-Alster²,

Broscheid³

et al. 2023

Eur J Phys Rehabil Med

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“…In this context, the metaverse represent the best choice to train cognition in real-world dual-and multi-tasks and to assess cognitive domains trained with specific DTT (Abasıyanık and Kahraman, 2022). The development of a large number of "deep feeling of presence" environments would allow dual-and multitasking training in all-around immersive situations (e.g., texting while shopping) without leaving home, tailored on the patientreported real-world cognitive deficits (e.g., cooking while having a conversation) and eventually enriched with the opportunity to interact with other connected persons (e.g., relatives, friends, and rehabilitator) and elicit emotions (e.g., happiness, surprise, and disgust).…”

Section: Training Dual-and Multi-tasks and Everyday Life Activities W...mentioning

confidence: 99%

“…The transfer of CR improvements into daily life would require the training in ecological environments with a large variety of tasks reproducing functional everyday life activities. For this purpose, the adoption of different forms of cognitive-motor dualand multi-task training, eventually using virtual environments, will be crucial to train PwMS in a context similar to that of everyday life (Goverover and DeLuca, 2018;Abasıyanık and Kahraman, 2022).…”

Section: Introductionmentioning

confidence: 99%

Cognitive rehabilitation in multiple sclerosis: Three digital ingredients to address current and future priorities

Tacchino

Podda²,

Bergamaschi³

et al. 2023

Front. Hum. Neurosci.

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Multiple sclerosis (MS) is a neurological chronic disease with autoimmune demyelinating lesions and one of the most common disability causes in young adults. People with MS (PwMS) experience cognitive impairments (CIs) and clinical evidence shows their presence during all MS stages even in the absence of other symptoms. Cognitive rehabilitation (CR) aims at reducing CI and improving PwMS’ awareness of cognitive difficulties faced in their daily living. More defined cognitive profiles, easier treatment access and the need to transfer intervention effects into everyday life activities are aims of utmost relevance for CR in MS. Currently, advanced technologies may pave the way to rethink CR in MS to address the priority of more personalized and effective, accessible and ecological interventions. For this purpose, digital twins, tele-cognitive-rehabilitation and metaverse are the main candidate digital ingredients. Based on scientific evidences, we propose digital twin technology to enhance MS cognitive phenotyping; tele-cognitive-rehabilitation to make feasible the cognitive intervention access to a larger number of PwMS; and metaverse to represent the best choice to train real-world dual- and multi-tasking deficits in virtual daily life environments. Moreover, multi-domain high-frequency big-data collected through tele-cognitive-assessment, tele-cognitive-rehabilitation, and metaverse may be merged to refine artificial intelligence algorithms and obtain increasingly detailed patient’s cognitive profile in order to enhance intervention personalization. Here, we present how these digital ingredients and their integration could be crucial to address the current and future needs of CR facilitating the early detection of subtle CI and the delivery of increasingly effective treatments.

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“…It occurs with greater frequency in the age group of 20-50 years, with twice the probability of occurrence of the disease in the female sex [1,[3][4][5]. Severe fatigue, muscle weakness, spasticity, paresthesias, motor dysfunctions, communication disorders, balance disorders, and reduced motor coordination in the lower limbs (LLs), resulting in 2 of 10 gait disturbance and falls as a consequence, are some of the clinical characteristics of the disease [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Validity and Reliability of the Lower Extremity Motor Coordination Test (LEMOCOT) in Patients with Multiple Sclerosis

Zarbouti,

Manola,

Christakou

et al. 2024

Applied Sciences

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The validity and reliability of the Lower Extremity Motor Coordination Test (LEMOCOT) were assessed in patients with multiple sclerosis (MS). The study involved 60 participants diagnosed with MS (mean age: 48.13 years, range: 24–80 years). Intra-rater reliability was assessed within-day (n = 12), and inter-rater reliability was assessed within-day (n = 45) and between-days (n = 22). For known-groups validity, test scores were compared between participants of different sexes; for convergent validity, test scores were correlated with age, the Five-Repetition Sit-to-Stand test (FSTS), the Berg Balance Scale (BBS), the Lower Extremity Functional Scale (LEFS), and the Expanded Disability Status Scale (EDSS). To test the discriminant validity, the LEMOCOT test scores were correlated with the Mini-Mental State Evaluation (MMSE) and compared according to social history (living alone or not). The LEMOCOT test was tested under three different conditions and found to be very reliable (intraclass correlation coefficient, ICC2,1 > 0.94) with an acceptable error level (standard error of the measurement, SEM, between 1.39 and 3.47 targets and 95% minimum detectable change; MDC95%, between 3.84 and 9.58 targets). Convergent validity was verified, as the LEMOCOT registered very strong correlations with the FSTS test (r = −0.851) and the BBS scale (r = 0.815), a strong correlation with the LEFS scale (r = 0.78), a moderate correlation with the EDSS scale (r = −0.634), all highly significant (p < 0.001), and a weak correlation with age (r = −0.332, p < 0.01). Discriminant validity was also confirmed, as the LEMOCOT demonstrated a weak correlation with the MMSE scale (r = 0.365, p = 0.017) and no differences relative to living environment or sex. The LEMOCOT demonstrated excellent reliability and validity for patients with MS.

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Effect of dual-task training on cognitive functions in persons with multiple sclerosis: A systematic review and meta-analysis

Cited by 6 publications

References 36 publications

Prefrontal hemodynamics during forward and backward walking, with and without a cognitive task, in people with multiple sclerosis

Prefrontal hemodynamics during forward and backward walking, with and without a cognitive task, in people with multiple sclerosis

Cognitive rehabilitation in multiple sclerosis: Three digital ingredients to address current and future priorities

Validity and Reliability of the Lower Extremity Motor Coordination Test (LEMOCOT) in Patients with Multiple Sclerosis

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