Effect of Drug Vehicle on Human Ocular Retention of Topically Applied Tetracycline

Massey, James Y.; Hanna, Calvin; Goodart, Roy; Wallace, Thomas

doi:10.1016/0002-9394(76)90726-1

Cited by 26 publications

(2 citation statements)

References 5 publications

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“…Owing to the wide range of properties, tetracyclines find therapeutic application not only in ophthalmic infections but also in other ophthalmic conditions such as dry eye syndrome (Federici, 2011). Tetracycline in aqueous or oily solution applied topically fails to provide sufficient aqueous humor levels; however, ointment formulation succeeds in achieving aqueous humor levels at bacteriostatic concentration (Massey et al, 1976). Systemic administration of tetracycline in rabbits was also shown to provide relatively low aqueous humor levels compared to vascular structures in eye.…”

Section: Antibacterial Drugsmentioning

confidence: 98%

Liposomes in topical ophthalmic drug delivery: an update

et al. 2014

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Topical route of administration is the most commonly used method for the treatment of ophthalmic diseases. However, presence of several layers of permeation barriers starting from the tear film till the inner layers of cornea make it difficult to achieve the therapeutic concentrations in the target tissue within the eye. In order to circumvent these barriers and to provide sustained and targeted drug delivery, tremendous advances have been made in developing efficient and safe drug delivery systems. Liposomes due to their unique structure prove to be extremely beneficial drug carriers as they can entrap both the hydrophilic and hydrophobic drugs. The conventional liposomes had several drawbacks particularly their tendency to aggregate, the instability and leakage of entrapped drug and susceptibility to phagocytosis. Due to this reason, for a long time, liposomes as drug delivery systems did not attract much attention of researchers and clinicians. However, over recent years development of new generation liposomes has opened up new approaches for targeted and sustained drug delivery using liposomes and has rejuvenated the interest of researchers in this field. In this review we present a summary of current literature to understand the anatomical and physiological limitation in achieving adequate ocular bioavailability of topically applied drugs and utility of liposomes in overcoming these limitations. The recent developments related to new generation liposomes are discussed.

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Section: Antibacterial Drugsmentioning

confidence: 98%

Liposomes in topical ophthalmic drug delivery: an update

et al. 2014

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“…In this study, we show that doxycycline not only decreased cell migration, proliferation, and contraction, but also suppressed the activity levels of MMPs and p38 MAPK in the human RPE cell line, ARPE-19. A previous study showed that topical tetracycline ointment can produce drug levels in the aqueous humor [ 42 ]. Therefore, we also used a combination of IVI doxycycline and topical tetracycline treatment in the PVR mouse model.…”

Section: Introductionmentioning

confidence: 99%

Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice

Chen

Lin

Wang

et al. 2021

IJMS

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After successful surgeries for patients with rhegmatogenous retinal detachment, the most common cause of retinal redetachment is proliferative vitreoretinopathy (PVR), which causes severe vision impairment and even blindness worldwide. Until now, the major treatment for PVR is surgical removal of the epiretinal membrane, while effective treatment to prevent PVR is still unavailable. Therefore, we investigated the potential of doxycycline, an antibiotic in the tetracycline class, to treat PVR using a mouse model. We used the human retinal pigment epithelial cell line, ARPE-19, for in vitro and in vivo studies to test doxycycline for PVR treatment. We found that doxycycline suppressed the migration, proliferation, and contraction of ARPE-19 cells with reduced p38 MAPK activation and total MMP activity. Intravitreal doxycycline and topical tetracycline treatment significantly ameliorated the PVR severity induced by ARPE-19 cells in mice. PVR increased the expression of MMP-9 and IL-4 and p38 MAPK phosphorylation and modestly decreased IL-10. These effects were reversed by doxycycline and tetracycline treatment in the mouse retina. These results suggest that doxycycline will be a potential treatment for PVR in the future.

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A Continuous-Wear Hydrophilic Lens

Binder¹

1976

Arch Ophthalmol

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Effect of Drug Vehicle on Human Ocular Retention of Topically Applied Tetracycline

Cited by 26 publications

References 5 publications

Liposomes in topical ophthalmic drug delivery: an update

Liposomes in topical ophthalmic drug delivery: an update

Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice

A Continuous-Wear Hydrophilic Lens

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