Effect of drug-induced pathomorphosis on oral cavity organs and tissues in chronic obstructive pulmonary disease combined with coronary heart disease: A clinical case

Emelyanova, Nataliya; Komir, I.

doi:10.15419/bmrat.v8i1.657

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Table 3 shows that the control group subjects had a significantly deeper periodontal sulcus than the main group subjects. However, loss of epithelial attachment in somatically healthy individuals is practically absent, while in the main group it is significant and differs from control values [36,37] .…”

Section: Discussionmentioning

confidence: 62%

Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis

Еmelyanov

Petrushanko

Emelyanova

2022

International Journal of Bone Fragility

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Purpose: This study is to determine the quantitative level of Porphyromonas gingivalis (P. gingivalis) in the periodontal pocket and its gingipain virulence factor in patients with non-alcoholic fatty liver disease (NAFLD). Methods: Dental status, composition of P. gingivalis, and levels of gingipain and blood endotoxin were studied in patients with NAFLD and in a control group. The quantitative composition of P. gingivalis was determined by the real-time quantitative polymerase chain reaction method (qRT-PCR). Gingipain K concentration in oral fluid was determined by an immunoenzymatic method. Results: The level of individual oral hygiene in the NAFLD patients was found to be unsatisfactory. Structurally, periodontal pathology was represented mainly by chronic grade B periodontitis. When analysing the correlation interaction, a positive dynamic was found between P. gingivalis and the presence of generalized periodontitis (GP) (r=0.652; p=0.000) and between gingipain and GP (r=0.510; p=0.006). The endotoxemia value correlated positively with the quantitative index of P. gingivalis (r=0.695; p=0.004), which is explained by the fact that periodontopathogen endotoxin (LPS), when entering the vascular bed, increases the systemic endotoxin level in general. Inflammation-causing cytokines and LPS in NAFLD contribute to the formation of an anaerobic environment in the periodontium that favours the quantitative growth of P. gingivalis. Conclusion: The highest levels of P. gingivalis and gingipain were recorded in patients with NAFLD, which is consistent with a background of decreased periodontal adaptive capabilities. The P. gingivalis/gingipain correlation ratio can allow the dentist to monitor the treatment of periodontal patients.

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Section: Discussionmentioning

confidence: 62%

Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis

Еmelyanov

Petrushanko

Emelyanova

2022

International Journal of Bone Fragility

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“…[16]. As a result, during xerostomia, the oral mucosa is affected, burning sensations appear, taste changes and bad breath appears, and the risk of periodontal disease increases [17]. The pH of the oral fluid is decreased, that contributes to the accumulation of plaque.…”

Section: Discussionmentioning

confidence: 99%

Results of Questioning Patients With Non-Alcoholic Fatty Liver Disease in the Conditions of Dental Practice

Еmelyanov

2021

Wiad Lek

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The aim: Is to develop and test questionnaires allowing systematization of the main dental complaints and knowledge on hygienic oral care in patients with non-alcoholic fatty liver disease (NAFLD) given their individual characteristics. Materials and methods: The developed questionnaires and database have been tested on 36 patients with NAFLD and 10 patients of the control group. Results: As a result of the study, it appears that the main dental complaints in patients with NAFLD are dry mouth and the associated need for frequent mouth rinsing with water, bleeding gums, mainly during teeth brushing, distortion of taste and bad breath. It has been noted that only 33.3% of patients regularly brush their teeth every morning and evening, while 25.0% of respondents brush their teeth only once a day. It is also characteristic that more than 25.0% of patients with NAFLD use mainly carbohydrate foods in their diet, and the smoking rate among this group is at least 58.0%. Conclusions: The use of this questionnaire makes it necessary to take into account all the “bottlenecks” in selection of measures for dental disease prevention in NAFLD, which currently is of high relevance and necessity.

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Effect of drug-induced pathomorphosis on oral cavity organs and tissues in chronic obstructive pulmonary disease combined with coronary heart disease: A clinical case

Cited by 2 publications

References 13 publications

Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis

Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis

Results of Questioning Patients With Non-Alcoholic Fatty Liver Disease in the Conditions of Dental Practice

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