Effect of drag-reducing polymers on the structure of the stagnant zones and eddies in models of constricted and branching blood vessels

Kameneva, Marina V.; Polyakova, M. S.; Fedoseeva, E. V.

doi:10.1007/bf01049712

Cited by 15 publications

(16 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using glass models of bifurcating vessels and measuring the flow velocity profiles in the vicinity of bifurcations at laminar flow with Reynolds numbers ranging from 1 to $250 (Kameneva, Polyakova, & Fedoseeva, 1990;Kameneva, Polyakova, & Gvozdkova, 1988), we demonstrated that DRPs reduced flow separations and vortex size, and delayed the development of vortices at vessel bifurcations (Fig. 9).…”

Section: Drp Effects On Flow Separations At Vessel Bifurcations At Lomentioning

confidence: 91%

“…9. Schematic presentation of the DRP effects on flow separations and eddies at blood vessel bifurcations in the vascular system prompted by the results of in vitro experiments (Kameneva, Polyakova, & Fedoseeva, 1990;Kameneva, Polyakova, & Gvozdkova, 1988) performed in glass models of bifurcating tubes using an automated Doppler anemometer to measure flow velocity profiles in neighborhood of bifurcations (Left: no DRP, right: DRP). Illustration by author.…”

Section: Drp Effects On Blood Flow In Microchannels In Vitromentioning

confidence: 99%

See 1 more Smart Citation

Microrheological effects of drag-reducing polymers in vitro and in vivo

Kameneva¹

2012

International Journal of Engineering Science

View full text Add to dashboard Cite

Section: Drp Effects On Flow Separations At Vessel Bifurcations At Lomentioning

confidence: 91%

Section: Drp Effects On Blood Flow In Microchannels In Vitromentioning

confidence: 99%

Microrheological effects of drag-reducing polymers in vitro and in vivo

Kameneva¹

2012

International Journal of Engineering Science

View full text Add to dashboard Cite

“…Although DRPs have been tested and used primarily in nonbiological settings (e.g., to reduce energy requirements for pumping petroleum) (10), several studies have shown that microvascular perfusion in the mammalian circulation is improved after intravenous injection of synthetic or natural DRPs (11-14, 20, 21). Although many investigators have attributed their in vivo results to decreased turbulence after injection of the DRPs, blood flow in the mammalian circulation is thought to be largely laminar (except for the aorta and great vessels during exercise) (22,23). Thus, although the mechanisms underlying the beneficial effects of DRPs on blood circulation remain to be identified, they are most likely different from the original Toms drag-reducing effect because there is minimal turbulent flow in the vascular system.…”

Section: Table 1 Effect Of Hemorrhage and Resuscitation With Vehiclementioning

confidence: 96%

“…It has been demonstrated that DRP reduces the size and delays the development of flow separations and vortices at vessel bifurcations under flow conditions corresponding to realistic vascular hemodynamics with Reynolds numbers 1 Յ Re Յ 400 (23). In vivo, this effect may reduce pressure loss in arterial vessels and thus increase precapillary pressure, promoting increased perfusion of blood through the capillary network.…”

Section: Table 1 Effect Of Hemorrhage and Resuscitation With Vehiclementioning

confidence: 96%

Survival in a Rat Model of Lethal Hemorrhagic Shock Is Prolonged Following Resuscitation With a Small Volume of a Solution Containing a Drag-Reducing Polymer Derived From Aloe Vera

Macias¹,

Kameneva

Tenhunen³

et al. 2004

Shock

View full text Add to dashboard Cite

Drag-reducing polymers (DRP) increase tissue perfusion at constant driving pressure. We sought to evaluate the effects of small-volume resuscitation with a solution containing a DRP in a rat model of hemorrhage. Anesthetized rats were hemorrhaged at a constant rate over 25 min. In protocol A, total blood loss was 2.45 mL/100 g, whereas in protocol B, total blood loss was 3.15 mL/100 g. Five minutes after hemorrhage, the animals were resuscitated with 7 mL/kg of either normal saline (NS) or NS containing 50 microg/mL of an aloe vera-derived DRP. In protocol B, a third group (CON) was not resuscitated. Whole-body O2 consumption (Vo2) and CO2 production (Vco2) were measured using indirect calorimetry. In protocol A, 5/10 rats in the NS group and 8/10 rats in the DRP group survived for 4 h (P = 0.14). Mean arterial pressure was higher in the DRP-treated group than in the NS-treated group 45 min after resuscitation (89 +/- 8 vs. 68 +/- 5 mmHg, respectively; P < 0.05). In protocol B, survival rates over 2 h in the DRP, NS, and CON groups were 5/15, 1/14, and 0/7, respectively (P < 0.05). Compared with NS-treated rats, those resuscitated with DRP achieved a higher peak Vo2 (9.0 +/- 1.0 vs. 6,3+/- 1.0 mL/kg/min) and Vco2 (9.0 +/- 1.1 vs. 6.0 +/- 1.0 mL/kg/min) after resuscitation. We conclude that resuscitation with a small volume of DRP prolongs survival in rats with lethal hemorrhagic shock.

show abstract

“…Many studies of polymer solutions in channels with complex geometries [102,103] in the Reynolds number regime relevant for arteries have shown that recirculation regions and the corresponding stagnation zones near contractions, expansions, and branches are reduced in size by polymer additives. Since these zones are at increased risk for atherogenesis [104], their reduction is a likely reason for the observed in vivo reduction in plaque deposition and atherosclerotic lesions.…”

Section: Effect Of Plasma Rheology On Cell Distributionmentioning

confidence: 99%

Cell Distribution and Segregation Phenomena During Blood Flow

Kumar

Graham

2014

Complex Fluids in Biological Systems

View full text Add to dashboard Cite

Blood is the archetype of a biological complex fluid. It is complex in the microstructural and mechanical sense, as a multiphase non-Newtonian viscoelastic fluid, and also in the biological sense, as a tissue that has a wide range of functions from delivery of oxygen and nutrients to response to injury and inflammation. These forms of complexity are interconnected, as the physical nature of blood as a multiphase fluid is intimately related to its biological functions. In the present chapter, we summarize basic features of the structure and biology of blood as well as observations of its dynamics during flow in the body. Emphasis will be put on flow at small scales, where the particulate nature of blood as a suspension of many different types of cells becomes important both physically and functionally. The first part of the chapter describes the nature and biological functions of the various components of blood, as well as the distribution of these components in blood vessels. In particular, it has long been observed that the various cellular components of blood are distributed very nonuniformly, a phenomenon that is physiologically important as well as fascinating from the fluid-dynamical point of flow. The second part of the chapter focuses on computational and theoretical approaches for predicting and understanding the distribution and segregation of blood cells in flow. Various numerical methods are described, with a focus on one of the most widely used for multiphase small-scale flows, the boundary integral method. Computational results for model suspensions are presented that allow careful study of the basic mechanisms underlying segregation phenomena and a model framework is introduced that incorporates these mechanisms in an idealized way. This framework is a stepping stone toward a unified understanding of these segregation phenomena that will hopefully be useful in aiding the development of therapies to modify and exploit blood flow phenomena for disorders as varied as cancer, sickle cell disease, and hemorrhage.

show abstract

Effect of drag-reducing polymers on the structure of the stagnant zones and eddies in models of constricted and branching blood vessels

Cited by 15 publications

References 2 publications

Microrheological effects of drag-reducing polymers in vitro and in vivo

Microrheological effects of drag-reducing polymers in vitro and in vivo

Survival in a Rat Model of Lethal Hemorrhagic Shock Is Prolonged Following Resuscitation With a Small Volume of a Solution Containing a Drag-Reducing Polymer Derived From Aloe Vera

Cell Distribution and Segregation Phenomena During Blood Flow

Contact Info

Product

Resources

About