Effect of Dose Rate on Local Control and Complications in Definitive Irradiation of T1-2 Squamous Cell Carcinomas of Mobile Tongue and Floor of Mouth with Interstitial Iridium-192

Floor of mouth carcinoma: Surgery still the dominant mode of treatment

“…Local control rates of 85-95% for T1, and 80-85% for T2 disease are recorded. 1,3 Soft tissue necrosis can occur in up to 30% of patients, 12 although this ultimately heals in nearly all patients. Tumour abutting up to and/or involving the mandibular arch is contraindicated for brachytherapy given the significant risk of bone necrosis.…”

Swallow recovery in an oral cancer patient following surgery, radiotherapy, and hyperthermia

“…8 Complications following radiotherapy for treatment of primary and recurrent tongue base and oropharyngeal tumors, including external beam radiotherapy, hyperthermia, and/or interstitial implantation, have been well-documented in the literature, including soft tissue necrosis. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] However, few studies have documented the effects on swallow functioning of radiotherapy as primary treatment for tongue base and oropharyngeal tumors.lg This study examined the effects of combined treatment with interstitial hyperthermia and radiotherapy in a previously external beam irradiated and surgically treated oral cancer patient. The patient described had initially demonstrated excellent swallow recovery using maneuvers following surgery and external beam irradiation.…”

Influencia de la tasa de dosis absorbida en el tratamiento del melanoma de uvea posterior con braquiterapia epiescleral

“…En braquiterapia de baja tasa en sobreimpresiones de mama, se han obtenido resultados contradictorios. Por una parte, se ha encontrado mejor control local a favor de las tasas de dosis superiores a 60 cGy/h [190] y por otra no se han encontrado diferencias entre 30 y 100 cGy/h [191].…”

“…Para una serie de pacientes con tumores de lengua y suelo de boca tratados con baja tasa de dosis se ha evidenciado que la corrección de dosis en función de la tasa de dosis puede llevar a un descenso en el control local sin beneficio en la tolerancia de la mucosa o los huesos entre 30 y 90 cGy/h. Sin embargo, la tolerancia en los tejidos sanos era mejor en los tratamientos con los límites inferiores de este rango [190]. No hay muchos trabajos que estudien la relación de la tasa de dosis absorbida en el punto de prescripción con el seguimiento de los pacientes.…”