Effect of Dose on Antibody Response to Subunit Influenza Vaccine

Feery, Brian J.; Hampson, Alan W.; Forsyth, J. R. L.; Evered, Maurice G.

doi:10.5694/j.1326-5377.1977.tb99166.x

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…The results of this study confirm previous reports that substantial homologous antibody responses follow one dose of subunit vaccine in adults (Feery et al 1976(Feery et al , 1977. The study also demonstrates the fact that substantial increases in titre occur to each of the vaccine components at the dosage used in this trial.…”

Section: Discussionsupporting

confidence: 88%

“…The study also demonstrates the fact that substantial increases in titre occur to each of the vaccine components at the dosage used in this trial. The response to the influenza B component of the vaccine was lower than the response to the influenza A components as in previous studies (Feery et al 1976(Feery et al , 1977, but 23 of 32 achieved a titre > 40. In a protection study in Australia in 1970, Gill et al (1971) found little or no vaccine-induced protection against influenza B infection, but the results of this study suggest that protective antibody titres have been induced in this group (Hobson et al 1972).…”

Section: Discussionsupporting

confidence: 63%

“…This difference could not be related to the age of the vaccinees in this particular study. In a previous study in third-year medical students in which the A component of a similar vaccine was A/Victoria/3/75, a similar boosting to the earlier variants of the Hong Kong H3N2 series was demonstrated, but there was minimal boosting to the H2N2 strains (Feery et al 1977). It is possible that the difference between these studies resulted from the difference in the age and experience of the participants, but it is also possible that it is due to a closer antigenic relationship between the A/Scotland/840/74 component and the earlier Asian strains.…”

Section: Discussionmentioning

confidence: 69%

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Homologous and heterologous antibody responses to subunit influenza virus vaccine

Feery¹,

Evered²,

Hayes

1978

J. Hyg.

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In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (HON1). There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 69%

See 1 more Smart Citation

Homologous and heterologous antibody responses to subunit influenza virus vaccine

Feery¹,

Evered²,

Hayes

1978

J. Hyg.

Self Cite

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“…The responses to the B component were lower in all groups than those induced by the H3N2 component as in previous studies, and the response to tlie larger dose in the monovalent B vaccine was signiflcantly greater than that induced by the smaller dose in the trivalent vaccine. Although it is not valid to draw conclusions from a comparison between responses to a monovalent and a trivalent vaccine, these results are similar to those in an earlier dose response study (Feery et al, 1977) which suggested that the response to immunization with influenza B viruses is dose-related, and that the optimum dose is yet to be determined.…”

Section: Discussionsupporting

confidence: 52%

Antibody Responses to Influenza Vaccines Containing a/Ussr/90/77

Feery¹,

Gallichio²,

Rodda³

et al. 1979

Aust J Exp Biol Med

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Summary. Studies were undertaken in adult groups aged 17-24 years, 25-64 years and 66-100 years to determine the haemagglutination-inhibiting antibody responses to sub-unit influenza vaccines containing A/USSR/90/77 (HlNl). Antibody responses to A/USSR/90/77 were low in all groups. The young adult group (17-24 years) produced a primary response to A/USSR/90/77 and showed a significant response to a second dose of vaccine, whereas their responses to the A/Texas/1/77 (H3N2) and B/Hong Kong/8/73 components were of the anamnestic type and showed no significant increase to a second dose. The adult (25-64 years) and aged (66-100 years) groups responded anamnestically to all three vaccine components. There was no impairment of the antibody response in the aged group in comparison with the response in the adult group. A comparative assay in microtitre trays and WHO plates showed two-to fourfold differences in antibody titre to A/USSR/90/77 in these systems.

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“…The effect of dose on serum antibody responses to whole virus and subunit influenza vaccines has been investigated previously. In general, small increments in dose (less than or equal to two-to fourfold) fail to elicit significantly higher levels of serum antibodies (5,8,13,20,21,27). Higher increments (10-fold or greater than standard doses) consistently have been shown to enhance serum antibody responses (15,16,18,19,23), although the slope of the dose-response curve is rather flat.…”

Section: Discussionmentioning

confidence: 95%