Effect of Dose of Fat and Fat Content of the Maintenance Diet on Postprandial Serum Triglyceride in Rats

Abstract

Postprandial blood triglyceride is believed to be a risk factor for coronary artery disease. In this study, rats were fed a fat emulsion orally to study the effect of daily diet on postprandial blood triglyceride. First, rats were fed different volumes of dairy cream or corn oil emulsions. The resulting serum triglyceride levels were influenced by time and dose. Second, the maintenance diet for rats was switched to a high-fat or a low-fat diet, and an oral fat tolerance test was conducted. A few days of high-fat feeding hastened the peak of serum triglyceride after administration. Two weeks of high-fat feeding elevated basal serum triglyceride, and the peak of postprandial triglyceride was submerged. The short-and medium-term fat content of the daily diet clearly affects the results of a fat loading test.

The Sex-Dependent Impact of Chronic Clozapine and Haloperidol Treatment on Characteristics of the Metabolic Syndrome in a Rat Model

“…Compared to cholesterol, triglyceride concentrations show a high variability and can be nutritionally aff ected. Kimura et al [ 64 ] discovered that time and intake amounts of fat infl uence triglyceride levels. So we assume that triglyceride levels, which presumably remain unchanged by antipsychotic drug application, are caused by the animals' overnight fasting, the time period in which rats normally have the main food intake.…”