Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi

Tubbs, L; Tingle, Malcolm D.

doi:10.1016/j.aquaculture.2006.09.013

Cited by 14 publications

(8 citation statements)

References 19 publications

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“…Muscle plus skin tissue samples of S. aurata were prepared according to Tubbs & Tingle (2006). Briefly, tissue sample was sheared, and subsequently 1 g of ground sample was placed in a 50 mL centrifuge tube.…”

Section: Sample Preparationmentioning

confidence: 99%

Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Kogiannou

Rigos

2020

Medit. Mar. Sci.

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The depletion pattern of praziquantel (PZQ) from gilthead sea bream (Sparus aurata) muscle plus skin was determined in this study. Fish averaging 100.2 ± 17.7 g and kept at 25oC received a PZQ-dosing of 150 mg/kg fish for 3 days. Muscle plus skin of each of ten fish were collected on days 1, 2, 3, 4, and 6 days post-treatment. Depletion of PZQ from the edible gilthead sea bream tissues was rapid, as its concentrations declined to 0.04 μg/g as early as 24 h post-treatment, while was undetectable at 72 h. This information confirms the fact that PZQ is depleted fast from farmed animals including fish such as the gilthead sea bream and its levels in edible tissues failed below the detection limit in approximately 75 dd.

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Section: Sample Preparationmentioning

confidence: 99%

Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Kogiannou

Rigos

2020

Medit. Mar. Sci.

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“…In the aquarium industry, PZQ has been used to treat trematode, cestode and monogene infestations in both freshwater ( Forwood, Harris & Deveney, 2013 ; Iles, Archdeacon & Bonar, 2012 ; Mitchell & Darwish, 2009 ; Mitchell, 2004 ; Santamarina et al, 1991 ) and marine fish and elasmobranchs ( Chisholm & Whittington, 2002 ; Ishimaru et al, 2013 ; Janse & Borgsteede, 2003 ; Shirakashi et al, 2012 ; Thoney, 1990 ; Tubbs & Tingle, 2006a ; Tubbs & Tingle, 2006b ; Yamamoto et al, 2011 ). Though this drug can be administered to fish orally ( Forwood, Harris & Deveney, 2013 ; Janse & Borgsteede, 2003 ; Tubbs, Mathieson & Tingle, 2008 ; Tubbs & Tingle, 2006a ; Tubbs & Tingle, 2006b ), it is also common for it to be dissolved in the water in which the infested animal lives ( Chisholm & Whittington, 2002 ; Forwood, Harris & Deveney, 2013 ; Iles, Archdeacon & Bonar, 2012 ; Mitchell & Darwish, 2009 ; Mitchell, 2004 ). “Bath” treatments can range in duration from several minutes to several days to effectively remove parasites.…”

Section: Introductionmentioning

confidence: 99%

Praziquantel degradation in marine aquarium water

Amber

Dawson

Ellis

et al. 2016

PeerJ

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Praziquantel (PZQ) is a drug commonly utilized to treat both human schistosomiasis and some parasitic infections and infestations in animals. In the aquarium industry, PZQ can be administered in a “bath” to treat the presence of ectoparasites on both the gills and skin of fish and elasmobranchs. In order to fully treat an infestation, the bath treatment has to maintain therapeutic levels of PZQ over a period of days or weeks. It has long been assumed that, once administered, PZQ is stable in a marine environment throughout the treatment interval and must be mechanically removed, but no controlled experiments have been conducted to validate that claim. This study aimed to determine if PZQ would break down naturally within a marine aquarium below its 2 ppm therapeutic level during a typical 30-day treatment: and if so, does the presence of fish or the elimination of all living biological material impact the degradation of PZQ? Three 650 L marine aquarium systems, each containing 12 fish (French grunts: Haemulon flavolineatum), and three 650 L marine aquariums each containing no fish were treated with PZQ (2 ppm) and concentrations were measured daily for 30 days. After one round of treatment, the PZQ was no longer detectable in any system after 8 (±1) days. The subsequent two PZQ treatments yielded even faster PZQ breakdown (non-detectable after 2 days and 2 ± 1 day, respectively) with slight variations between systems. Linear mixed effects models of the data indicate that day and trial most impact PZQ degradation, while the presence of fish was not a factor in the best-fit models. In a completely sterilized marine system (0.5 L) PZQ concentration remained unchanged over 15 days, suggesting that PZQ may be stable in a marine system during this time period. The degradation observed in non-sterile marine systems in this study may be microbial in nature. This work should be taken into consideration when providing PZQ bath treatments to marine animals to ensure maximum drug administration.

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“…However, the duration of EB efficacy was reported to be 3-4 months [12,13], while PZQ is rapidly absorbed and eliminated in 24 h after an oral administration in yellowtail kingfish (Seriola lalandi) [14,15] and in Pacific bluefin tuna (Thunnus orientalis) [16]. In Japanese amberjack, concentrations of PZQ in plasma, skin mucus, muscle liver, and kidney decrease to below detectable limits within 48 h of oral administration of 150 mg/kg for 3 days [17].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Monitoring of Praziquantel in Water and Sediments at a Japanese Amberjack (Seriola quinqueradiata) Aquaculture Site

Ido

Kanemaru²,

Tanioka³

2019

Fishes

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Praziquantel (PZQ), an active compound against Platyhelminthes, is an essential anthelmintic for the aquaculture industry. However, there are few reports of the environmental risks of PZQ use in aquaculture. In this study, we monitored PZQ in water and sediment at an aquaculture site of Japanese amberjack, also called yellowtail (Seriola quinqueradiata). Although PZQ was detected in water during treatment and 3 days post-treatment, PZQ levels were below the detectable limit in water 60 m from the net pen during the treatment, and in all sediment samples. In this preliminary study, we could not detect residue of PZQ from sediments in the aquaculture site, and no evidence about environmental effect of PZQ administration was obtained.

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Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi

Cited by 14 publications

References 19 publications

Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Praziquantel degradation in marine aquarium water

Preliminary Monitoring of Praziquantel in Water and Sediments at a Japanese Amberjack (Seriola quinqueradiata) Aquaculture Site

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