Effect of Dose, Binding Affinity and Molecular Size on Tumour Uptake of Antibody or Ligand

Thomas, GD; Chappell, M. J.; Dykes, P.W.; Ramsden, D.; Godfrey, K.R.; Ellis, John R.; Bradwell, Arthur R.

doi:10.1042/cs076026p

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 The transcapillary flow from the central vascular spaces to the interstitial space of the "rest" was fixed. 24 To reduce complexity, total blood flow to liver is not divided into arterial and venous from the GI system and spleen.…”

Section: Iib Pbpk Modelsmentioning

confidence: 99%

Differences in predicted and actually absorbed doses in peptide receptor radionuclide therapy

et al. 2012

View full text Add to dashboard Cite

Purpose: An important assumption in dosimetry prior to radionuclide therapy is the equivalence of pretherapeutic and therapeutic biodistribution. In this study the authors investigate if this assumption is justified in sst2‐receptor targeting peptide therapy, as unequal amounts of peptide and different peptides for pretherapeutic measurements and therapy are commonly used. Methods: Physiologically based pharmacokinetic models were developed. Gamma camera and serum measurements of ten patients with metastasizing neuroendocrine tumors were conducted using111In‐DTPAOC. The most suitable model was selected using the corrected Akaike information criterion. Based on that model and the estimated individual parameters, predicted and measured 90Y‐DOTATATE excretions during therapy were compared. The residence times for the pretherapeutic (measured) and therapeutic scenarios (simulated) were calculated. Results: Predicted and measured therapeutic excretion differed in three patients by 10%, 31%, and 7%. The measured pretherapeutic and therapeutic excretion differed by 53%, 56%, and 52%. The simulated therapeutic residence times of kidney and tumor were 3.1 ± 0.6 and 2.5 ± 1.2 fold higher than the measured pretherapeutic ones. Conclusions: To avoid the introduction of unnecessary inaccuracy in dosimetry, using the same substance along with the same amount for pretherapeutic measurements and therapy is recommended.

show abstract

Section: Iib Pbpk Modelsmentioning

confidence: 99%