Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma

Harris, Alon; Jonescu-Cuypers, Christian P.; Kagemann, Larry; Nowacki, Elizabeth Anne; Garzozi, Hanna J.; Cole, Craig; Martin, Bruce

doi:10.1016/s0002-9394(01)01158-8

Cited by 55 publications

(40 citation statements)

References 15 publications

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“…These results are in contrast with some clinical studies 40 but agree with those reported in a previous study 39 conducted by our group on the haemodynamic effects of timolol monotherapy vs fixed combination D/T in POAG patients, where we observed a nonsignificant increase in HRF parameter values at the peripapillary retina and neuroretinal rim after the switch from timolol monotherapy to D/T.…”

Section: Discussionsupporting

confidence: 88%

“…The fixed combination of timolol and dorzolamide (D/T) has been proven to be as effective in lowering IOP as the concomitant use of the two molecules and more effective than either in monotherapy. 23,[37][38][39][40] Additionally, it has been reported that AVP time (superior temporal artery) was significantly accelerated using D/T as compared to timolol in glaucoma patients 40 and that the D/T fixed combination significantly increased POBF in POAG patients. 41 The aim of the present study was to evaluate the effect of dorzolamide 2% and timolol 0.5% in monotherapy and dorzolamide/timolol fixed combination on IOP and on retinal and ONH blood flow in early and moderate POAG patients to better define the therapeutic potential of these drugs.…”

Section: Introductionmentioning

confidence: 99%

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The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP) and retinal and optic nerve head haemodynamics in primary open-angle glaucoma patients. Methods Twenty-eight patients with early-moderate glaucomatous damage treated with b-blockers (46 months) with IOP values ranging from 18 to 22 mmHg at trough participated in this trial. After a 4-week washout period, patients were randomized in two groups: group I started with dorzolamide 2% monotherapy and group II with timolol 0.50% monotherapy for 4 weeks. After this period, both groups switched to dorzolamide/ timolol fixed combination for 4 weeks. IOP, ocular diastolic perfusion pressure (ODPP), heart rate, and Scanning Laser Doppler Flowmetry measurements at the peripapillary retina and neuroretinal rim were taken at T0 (enrolment), T1 (wash out), T2 (monotherapy), and T3 (dorzolamide/timolol). Data were compared between different study times. Statistical analysis was conducted using a paired t-test. Results Between T1 and T3, IOP decreased significantly in group I (À21.40%) (Po0.001) and in group II (À21.25%) (Po0.001). At the same time intervals, blood flow increased significantly at rim level for group I ( þ 30.03%) (Po0.05) and also when all patients were considered (rim þ 17.99%) (Po0.05). Between T1 and T3, we also observed a significant increase of ODPP in group I ( þ 7.24%) (Po0.01) and in group II ( þ 6.08%) (Po0.05) and when all patients were considered ( þ 8.43%) (Po0.01). Conclusions Dorzolamide/timolol fixed combination increased blood flow significantly at the neuroretinal rim showing a combination of hypotensive and haemodynamic effects.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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“…Regarding dorzolamide, positive effects on ocular haemodynamics are reported. [13][14][15] With the results from the present study, we were able to reproduce the previously described accelerating effects of dorzolamide on ocular blood flow and reduction of resistance in the SPCA, but, in contrast, could not determine a change in vCDI readings. This is a further indicator that vCDI in its present form is not applicable for use as a clinical diagnostic tool or for scientific purposes.…”

Section: Discussionsupporting

confidence: 68%

“…(4) Finally, in 15 patients, the capacity of the method to identify changes of ocular perfusion was tested by topically applying dorzolamide, an inhibitor of the carbonic anhydrase, which has been shown to increase ocular perfusion in glaucoma patients. [13][14][15] The study was performed under blinded conditions. Thus, evaluation of all four steps of the study was performed after completion of the entire data collection.…”

Section: Study Protocolmentioning

confidence: 99%

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Zeitz

Vilchez

Matthiessen

et al. 2005

Eye

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Purpose Disturbed ocular haemodynamics are discussed to contribute to the pathogenesis of glaucoma. Up to now there is no method available allowing direct determination of blood flow, which is the most relevant dimension for studies on haemodynamics. In this study, volumetric colour Doppler imaging (vCDI) is evaluated systematically in glaucoma patients. Methods A Siemens Elegra ultrasound set-up with a linear 7.5 MHz probe was used for all CDI measurements. For vCDI, the crosssectional area of a vessel and the flow velocity is determined. From both these parameters blood flow can be calculated. Ocular pulse amplitude (OPA) was assessed by the method of Langham using a pneumatic applanation tonometer. Results (1) Velocity measurements using CDI in the ophthalmic artery and central retinal artery were highly reproducible (n ¼ 20). In contrast, reproducibility of vCDI measurements was low (n ¼ 20). Reproducibility improved if five vCDI measures were averaged. (2) Results from two different CDI-operators did not differ regarding the velocity measurements, but there was a difference in vCDI measurements (n ¼ 20). (3) Results from vCDI did not correlate with measurements of OPA in 69 patients. (4) In 15 patients, vCDI failed to detect changes of ocular perfusion induced by the application of dorzolamide. Conclusion vCDI is not applicable in ophthalmology at present.

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“…In multiple studies, we also failed to detect significant changes in CDI parameters. [2][3][4][5] The present findings support the existing literature suggesting that arterio-venous passage times are more sensitive to changes in retinal haemodynamics than CDI.…”

Section: Sirsupporting

confidence: 89%

The clinical utility of colour Doppler imaging

Kagemann

Harris

2007

Eye

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Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma

Cited by 55 publications

References 15 publications

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

The clinical utility of colour Doppler imaging

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