Effect of dopexamine hydrochloride in the early stages of experimental myocardial infarction and comparison with dopamine and dobutamine

Role of β1- and β2-adrenergic receptors in regulation of Cl−and Ca2+channels in guinea pig ventricular myocytes

“…Our results suggest that they are not functionally coupled to the cAMP-dependent regulation of ion channels. The observation that ␤ 1 -and ␤ 2 -adrenergic receptor stimulation can have distinctly different effects on electrical activity is important because it may help explain previous H1675 ␤ 1 -AND ␤ 2 -ADRENERGIC REGULATION OF CARDIAC ION CHANNELS reports indicating that ␤ 1 -adrenergic stimulation is much more likely to be arrhythmogenic (4,19).…”

“…Although some studies have examined the role that ␤ 1 -and ␤ 2 -adrenergic receptors may play in regulating contractile function, the results have not been consistent (14,25). Even fewer studies have looked at the role of ␤-receptor subtypes in regulating electrical activity (1,4,19,24,25).…”

Postcardiac surgery low cardiac output syndrome: dopexamine or dopamine?

“…This was observed even though the dopexamine group contained generally higher risk patients: a larger number of females and patients with poorer left ventricular function prior to surgery [5]. In this model, dopexaminetreated rats had less ventricular ectopic activity than those treated with dopamine [7]. However, in achieving increased cardiac output it is important not to put the patients at further risk of cardiac dysrhythmias or increased cardiac work.…”

Arrhythmogenic potential of dopexamine hydrochloride during halothane anaesthesia in dogs

“…Similar haemodynamic data from anaesthetized dogs were reported by other investigations. 1,3,15 Despite extensive investigation, the exact mechanism by which catecholamines induce arrhythmias during halothane anaesthesia has not been established. Katz et al s,lt reported that stimulation of myocardial beta adrenoreceptors 131 and 132 was mainly responsible for these arrhythmias.…”