Effect of Dopamine Infusion on Hemodynamics after Hepatic Denervation

Wise, Paul E.; Wiley, David H.; Drougas, James G.; Marsh, John; Feurer, Irene D.; Chapman, William C.; Blair, K.Taylor; Wright, J. Kelly; Eddy, Virginia A.; Pinson, C. Wright

doi:10.1006/jsre.2000.6064

Cited by 3 publications

(7 citation statements)

References 19 publications

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“…In addition, denervation effects were previously studied in combination with pharmacologic modulation. One study reported an increase of HAF after hepatic denervation in pigs during dopamine infusion but no increase of THF (or PVF) 16. Denervation caused blunting of PVF increase during systemic dopamine administration compared with control subjects in another study 32.…”

Section: Discussionmentioning

confidence: 90%

“…This variation could indicate that the basal autonomic tone in the portal vein is sometimes very low, and PVF is primarily dependent on splanchnic blood flow, which is influenced by the vasomotor tone of the superior mesenteric artery 50. There is also discrepancy concerning the effects of denervation on HAF, but in most studies, an increment of HAF was reported after denervation 16, 50–54…”

Section: Discussionmentioning

confidence: 98%

“…The hepatic artery provides 15–30% of the blood flow to the liver, and the portal vein contributes 70–85% 16, 26, 27. Accordingly, there is mixture of the high‐pressure, well‐oxygenated arterial inflow and the low‐pressure, less‐oxygenated but nutrient‐laden portal inflow.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, some controversies exist concerning the effects of different catecholamines particularly on splanchnic vasculature. Effects of dopamine have been assessed in multiple studies,16–18 with the kidney being the most studied intraabdominal organ 19. In contrast, data on epinephrine (Epi) or norepinephrine (NorEpi) effects on perfusion of visceral organs are rather scarce 15, 20.…”

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confidence: 99%

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Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Mehrabi¹,

Golling²,

Kashfi³

et al. 2005

Liver Transpl

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Catecholamines are often administered during and after liver transplantation (LTx) to support systemic perfusion and to increase organ oxygen supply. Some vasoactive agents can compromise visceral organ perfusion. We followed the hypothesis that the vasculature of transplanted livers presents with a higher sensitivity, which leads to an increased vulnerability for flow derangement after application of epinephrine (Epi) or norepinephrine (NorEpi).

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Mehrabi¹,

Golling²,

Kashfi³

et al. 2005

Liver Transpl

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“…Atta et al [19] demonstrated that liver denervation resulted in a significant increase in the hepatic arterial flow and a decrease in the portal venous flow, thus resulting in no change in the total liver blood flow. On the other hand, Wise et al [20] demonstrated liver denervation to result in a significant increase in both the hepatic arterial flow and the portal venous flow. Our experiment showed results that were similar to the latter, although we only measured total hepatic flow.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Denervation on Liver Regeneration in Partially Hepatectomized Rats

Hamada

Eguchi

Yanaga

et al. 2007

Journal of Surgical Research

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Transplanted liver: Consequences of denervation for liver functions

et al. 2004

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Following liver transplantation, all hepatic nerves are transected; thus, liver allografts are completely isolated from neural control of their hosts. Despite this absolute denervation, liver allograft function does not appear to be significantly impaired after successful transplantation. In experimental animal models, hepatic denervation has no major effects on bile acid production and biotransformation, while it increases blood pressure and salt retention; decreases the number of hepatic progenitor cells, cholangiocyte proliferation, and liver regeneration; and influences the hepatic microcirculation, diet behavior, and glycemic control. In humans, hepatic denervation after liver transplantation has no major deleterious effects on bile secretion, liver regeneration, and hepatic blood flow. Insulin resistance and postprandial hyperglycemia, changes in ingestion behavior, and reduced stimulation of hepatic progenitor cells in the canals of Hering are the major side effects of absent liver innervation. Despite these abnormalities, patients can lead a new life with improved quality of life. © 2004 Wiley-Liss, Inc. Key words: liver transplantation; denervation; function; hepaticLiver transplantation is the ultimate treatment for patients with acute fulminant and chronic liver failure. The results of liver transplantation are good, with a 1-year survival of 90 -95% and a 10-year survival of 50 -60%. Because of a shortage in cadaveric donors, living-related liver transplantation is a good option to overcome this problem.The autonomic nerves of the liver are formed by an anterior plexus (around the hepatic artery) and a posterior plexus (surrounds portal vein and bile duct). Parasympathetic nerves are derived from the vagus nerve and the sympathetic fibers from the celiac ganglion. Sensory nerve endings are present in the liver capsule, central veins, and bile ducts. Most of the afferent nerves from the liver run via the vagus and splanchnic nerves, but some also to the right phrenic nerve. The afferent nerves register information from nocireceptors, osmo-and baroreceptors, as well as ionic and metabolic receptors (Bathal and Grossman, 1999).Following liver transplantation, the hepatic nerves are inevitably transected below the porta hepatis or at the hepatoduodenal ligament; thus, liver allografts are completely isolated from the neural control of their hosts. Despite this absolute denervation, the liver allograft does not appear to be significantly compromised after successful transplantation. There is no obvious deficiency in the regulation of liver metabolism (production of proteins such as albumin and coagulation factors, metabolization) and bile production. At first blush, it seems that under normal circumstances, hormones and substrates reaching the liver by circulation are responsible for control of the organ function, and that the role of hepatic nerves is mainly restricted to situations of physiological stress.However, a more profound search revealed that hepatic denervation has a lot of consequences...

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Effect of Dopamine Infusion on Hemodynamics after Hepatic Denervation

Cited by 3 publications

References 19 publications

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

The Effect of Denervation on Liver Regeneration in Partially Hepatectomized Rats

Transplanted liver: Consequences of denervation for liver functions

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