Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3 years: The road towards new recommendations

Abou-Jaoudé, Maroun M; Hage, Said El; Akiki, Dany; Araman, Rita

doi:10.1016/j.trim.2021.101490

Cited by 2 publications

(2 citation statements)

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“…Overall, infections are the predominant cause for hospital readmission within the first year following KT (49%, n = 202/296) 41 . Bacterial infections are most frequent after KT, followed by viral infections, with fungal and parasitic infections being much rarer 34,36,42,43 . UTI after KT are the most common infectious complication, albeit with decreasing prevalence since the 1990s 34,42,44,45 .…”

Section: Resultsmentioning

confidence: 99%

“…41 Bacterial infections are most frequent after KT, followed by viral infections, with fungal and parasitic infections being much rarer. 34,36,42,43 UTI after KT are the most common infectious complication, albeit with decreasing prevalence since the 1990s. 34,42,44,45 In a meta-analysis of 13 studies (n = 3 364), the pooled prevalence of UTIs in KT recipients was 38.0% (95% CI, 29%-47%; p < .01).…”

Section: Rdscmentioning

confidence: 99%

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Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review

Magyar,

Gretener,

Baldi

et al. 2024

Clinical Transplantation

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IntroductionSolid organ transplantation (SOT) is a lifesaving treatment for end‐stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear.MethodsA scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation. All studies up to February 2023 were included.ResultsMultiple studies published between 1998 and 2022 show that RDSC is an important factor affecting the outcome after organ transplantation. Male recipients of SOT have a higher risk of mortality and graft failure than female recipients. Differences regarding the causes of death are observed. Female recipients on the other hand are more susceptible to infections after SOT.ConclusionDifferences in underlying illnesses as well as age, immunosuppressive therapy and underlying biological mechanisms among male and female SOT recipients affect the post‐transplant outcome. However, the precise mechanisms influencing the interaction between RDSC and post‐transplant outcome remain largely unclear. A better understanding of how to identify and modulate these factors may improve outcome, which is particularly important in light of the worldwide organ shortage. An analysis for differences of etiology and causes of graft loss or mortality, respectively, is warranted across the RDSC groups.Practitioner points Recipient and donor sex combinations affect outcome after solid organ transplantation. While female recipients are more susceptible to infections after solid organ transplantation, they have higher overall survival following SOT, with causes of death differing from male recipients. Sex‐differences should be taken into account in the post‐transplant management.

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Section: Resultsmentioning

confidence: 99%