Effect of donor/recipient body weight ratio, donor weight, recipient weight and donor age on kidney graft function in children

Spaténka, J; Seeman, Tomáš; Foltynová, Eva; Burkert, Jan; Dušek, Jiří; Vondrák, Karel; Janda, Jan; Habrmanová, Anna; Krejčová, Jana; Matoušovic, K

doi:10.1093/ndt/gfr319

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…A surrogate measure such as donor weight‐to‐recipient weight ratio or allograft mass‐to‐recipient size ratio can be good predictors for the post‐transplantation renal function . In particular, a study by Špatenkaet al (2012) has postulated that the surrogate measurement of donor‐to‐recipient body weight ratio is directly correlated with eGFR in the early and late pediatric post–renal transplant periods . Furthermore, a previous study by Hugen et al (2011) assessed the relationship of the RAV/rBSA and post‐transplant renal function among adult living kidney donors and showed a similar correlation of RAV/rBSA to nadir serum creatinine levels at 1 year post‐transplant .…”

Section: Discussionmentioning

confidence: 95%

“…The current literature on adult and PRT has described the physiology of the donor nephron's mass volume needed to attain the metabolic requirements of the recipient. A surrogate measure such as donor weight‐to‐recipient weight ratio or allograft mass‐to‐recipient size ratio can be good predictors for the post‐transplantation renal function . In particular, a study by Špatenkaet al (2012) has postulated that the surrogate measurement of donor‐to‐recipient body weight ratio is directly correlated with eGFR in the early and late pediatric post–renal transplant periods .…”

Section: Discussionmentioning

confidence: 99%

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Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant

Chua

Kim

Gnech

et al. 2018

Pediatric Transplantation

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Our study aims to assess the clinical implication of RAV/rBSA ratio in PRT as a predictor for attained renal function at 1 year post‐transplantation and its association with surgical complications. A retrospective cohort was performed for PRT cases from January 2000 to December 2015 in our institution. Extracted clinical information includes the recipient's demographics, donor type, renal allograft characteristics, arterial, venous and ureteral anastomoses, vascular anastomosis time while kidney off ice, overall operative time, and estimated blood loss. The RAV/rBSA was extrapolated and assessed for its association with renal graft function attained in 1 year post‐transplantation and surgical complications within 30‐day post‐transplantation. A total of 324 PRTs cases were analyzed. The cohort consisted of 187 (52.4%) male and 137 (42.3%) female recipients, with 152 (46.9%) living donor and 172 (53.1%) deceased donor renal transplants, and an overall median age of 155.26 months (IQR 76.70‐186.98) at time of renal transplantation. The receiver operating characteristic identified that a RAV/rBSA ratio of 135 was the optimal cutoff in determining the renal graft function outcome. Univariate and multivariate analyses revealed the relative OR for RAV/rBSA ≥ 135 ratio in predicting an eGFR ≥ 90 attained within 1 year post‐transplant was highest among younger pediatric recipients (<142.5 months) of deceased kidney donors (OR = 11.143, 95% CI = 3.156‐39.34). Conversely, Kaplan‐Meier analysis revealed that RAV/rBSA ratio ≥ 135 is associated with lower odds of having eGFR <60 (OR = 0.417, 95% CI = 0.203‐0.856). The RAV/rBSA ratio was not associated nor predictive of transplant‐related surgical complications. Our study determined that the RAV/rBSA ratio is predictive of renal graft function at 1‐year PRT, but not associated with any increased surgical complications.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant

Chua

Kim

Gnech

et al. 2018

Pediatric Transplantation

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“…Other study which showed a positive correlation between high dkw/rbw ratio and graft function is by Spatenka et al . [14]…”

Section: Discussionmentioning

confidence: 99%

A study to evaluate the effect of ratio of donor kidney weight to recipient body weight on renal graft function

et al. 2014

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Aim and Objectives:To study the effect of the ratio of donor kidney weight (dkw) to recipient body weight (rbw) on short and long term graft function in live donor kidney transplant patients.Materials and Methods:It was a prospective study of 79 live donor kidney transplant recipients. Patients were divided into three groups depending on the ratio of dkw in grams to rbw in kilograms. Serum creatinine in milligrams percent on the day of surgery, 7th day, 1 month, 6 months, 1 year, and 3 years after the surgery was recorded and their means compared.Results:The comparison showed that the decrease in mean creatinine level was more in group three patients as compared with group 2 and one patients at 7 days (1.04,1.44 and 1.59 in group 3,2 and 1 respectively) and 30 days (1.12,1.36 and 1.45 in group 3,2 and 1 respectively), showing that higher dkw/rbw ratio is beneficial with respect to the early graft function. However this decrease was not statistically significant (P value –0.256 and 0.358 respectively on 7th and 30th day). Furthermore long-term function was not different among these three groups.Conclusion:The ratio of dkw to rbw does not have a significant effect on long-term graft function inspite of an early improvement in the function with increased dkw to rbw ratio.

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“…A number of living donor factors such as older donor age, lower nephron dose estimated by donor recipient body weight ratio, lower donor estimated glomerular filtration rate (eGFR) and human leukocyte antigen (HLA) match had been considered as key influential determinants on the short and long‐term graft and patient outcomes in developed countries . However, little is known about the prognostic factors that may impact on the overall graft and patient survival in emerging economies, where living donors are the major sources of donor organs.…”

mentioning

confidence: 99%

“…6,7 A number of living donor factors such as older donor age, lower nephron dose estimated by donor recipient body weight ratio, lower donor estimated glomerular filtration rate (eGFR) and human leukocyte antigen (HLA) match had been considered as key influential determinants on the short and long-term graft and patient outcomes in developed countries. [8][9][10][11][12][13][14][15] However, little is known about the prognostic factors that may impact on the overall graft and patient survival in emerging economies, where living donors are the major sources of donor organs. A key dilemma faced by physicians and in particular, younger patients with ESRD in the developing world is the choice of accepting a kidney from an older donor such as parents/grandparents or from a younger sibling within the family.…”

mentioning

confidence: 99%

Living donor risk model for predicting kidney allograft and patient survival in an emerging economy

et al. 2018

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Similar to findings in high income countries, our study suggests that donor characteristics such as age, nephron dose, creatinine clearance and HLA match are important factors that determine the long-term patient and graft survival in low income countries. However, other crucial but undefined factors may play a role in determining the overall risk of graft failure and mortality in living kidney donor transplant recipients.

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Effect of donor/recipient body weight ratio, donor weight, recipient weight and donor age on kidney graft function in children

Abstract: In paediatric renal transplants, the value of D/R BWR directly correlated with eGFR in the early and late posttransplant periods. However, this correlation was mainly influenced by the recipient weight, while the donor weight played only a minor or negligible role.

Cited by 11 publications

References 23 publications

Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant

Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant

A study to evaluate the effect of ratio of donor kidney weight to recipient body weight on renal graft function

Living donor risk model for predicting kidney allograft and patient survival in an emerging economy

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