Effect of domperidone on apomorphine-induced growth hormone secretion in normal men

Lal, Samarthji; Nair, N.P.V.; Iskandar, Hani; Étienne, Pierre; Wood, Paul L.; Schwartz, George J.; Guyda, H.

doi:10.1007/bf01249280

Cited by 32 publications

(5 citation statements)

References 44 publications

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“…7). We have found that pramipexole, like other D 2 dopamine receptor agonists (Lal et al, 1975;Müller et al, 1991; for review see Müller et al, 1999), increased GH secretion in agreement with a previous report (pramipexole : Schilling et al, 1992). It is believed that the GH release-promoting effect of the dopaminomimetic drugs is due primarily to a reduction in the release of SS (Vance et al, 1987;Giustina and Veldhuis, 1998).…”

Section: Discussionsupporting

confidence: 90%

Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers

Samuels

Hou²,

Langley³

et al. 2006

J Psychopharmacol

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The noradrenergic locus coeruleus is a major wakefulness-promoting nucleus of the brain, which is also involved in the regulation of autonomic and endocrine functions. The activity of the locus coeruleus is believed to be tonically enhanced by a mesocoerulear dopaminergic pathway arising from the ventral tegmental area of the midbrain. Both modafinil, a wakefulness-promoting drug, and pramipexole, a D(2)/D(3)receptor agonist with sedative properties, may act on this pathway, with modafinil increasing and pramipexole decreasing locus coeruleus activity. The aim of this study was to compare the two drugs on alertness, autonomic and endocrine functions in healthy volunteers. Pramipexole (0.5mg), modafinil (200mg), and their combination were administered to 16 healthy males in a double-blind, placebo-controlled design. Methods included tests of alertness (pupillographic sleepiness test, critical flicker fusion frequency, visual analogue scales), autonomic functions (resting pupil diameter, light and darkness reflex responses, heart rate, blood pressure, salivation, core temperature), and endocrine functions (blood concentrations of prolactin, growth hormone, and thyroid stimulating hormone). Data were analysed by ANOVA. Pramipexole reduced alertness, caused pupil dilatation, increased heart rate, reduced prolactin and thyroid stimulating hormone, and increased growth hormone level. Modafinil caused small increases in blood pressure and core temperature, and reduced prolactin levels. The sedative effect of pramipexole and the autonomic effects of modafinil are consistent with altered activity in the mesocoerulear pathway; the pupil dilatation following pramipexole suggests reduced dopaminergic excitation of the Edinger-Westphal nucleus.

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Section: Discussionsupporting

confidence: 90%

Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers

Samuels

Hou²,

Langley³

et al. 2006

J Psychopharmacol

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“…This APO-induced penile erection and yawning was shown to be inhibited by central dopamine receptor antagonists such as sulpiride, 16 haloperidol 17 and metoclopramide, 18 but not by peripheral dopamine receptor antagonists such as domperidone which cannot pass the blood ± brain barrier. 19,20 These ®ndings would suggest that APO-induced penile erection is mediated by central mechanisms that involves activation of dopamine receptors. One site of central action of APO is believed to be the paraventricular nucleus of the hypothalamus, since APO-induced penile erection is abolished in the presence of paraventricular nucleus lesions 21 while direct administration of APO into the paraventricular nucleus causes penile erection.…”

Section: Discussionmentioning

confidence: 99%

Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit

et al. 2000

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Clitoral and vaginal engorgement during sexual stimulation depend in part on the increase of arterial in¯ow. It has been shown that apomorphine (APO), a non-selective dopamine receptor agonist, produces penile erection by activating dopaminergic receptors in the central nervous system. Our aim was to study whether systemic administration of APO improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit.Female New Zealand white rabbits (3.5 ± 4 kg, n 6) were anesthetized. To examine sexual arousal function, the vaginalaclitoral branch of the pelvic nerve was stimulated electrically and maximal increases in clitoral intracavernosal and vaginal wall blood¯ows and pressures were recorded. After this APO was injected intravenously in a dose ± response manner (0.05, 0.1, 0.2, 0.3 and 0.4 mgakg) and nerve stimulation was performed after each dose. Changes in nerve-stimulated increase of clitoral intracavernosal and vaginal blood¯ows and pressures after APO was compared to those recorded before APO.Electrical stimulation of the vaginalaclitoral branch of the pelvic nerve signi®cantly increased clitoral intracavernosal and vaginal wall blood¯ows in the rabbit. Intravenous administration of APO caused concentration dependent increase in nerve stimulation-induced peak clitoral intracavernosal and vaginal wall blood¯ows reaching to statistically signi®cant at the concentration of 0.1 and 0.2 mgakg. Inravenous administration of APO greater than 0.2 mgakg (0.3 and 0.4 mgakg) were less effective or produced adverse effects on clitoral intracavernosal and vaginal wall blood¯ows. Intravenous APO also tended to increase nerve-stimulated increase of clitoral intracavernosal and vaginal wall pressures, but the effect was not statistically signi®cant.In conclusion, our studies suggest that systemic administration of APO may improve clitoral and vaginal engorgement by increasing clitoral intracavernosal and vaginal wall arterial in¯ow.

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“…The present studies in man suggest that CCK-33 has no effect on basal GH or PRL secretion. Apo increases GH secretion by an effect on a DA receptor within the hypothalamic-pituitary axis which is not linked to adenylate cyclase and which lies outside the blood brain barrier (Lal, Nair, Iskandar, Etienne, Wood, Schwartz and Guyda 1982). The DA receptor modulating PRL secretion is also located outside the blood brain barrier.…”

Section: Discussionmentioning

confidence: 99%

Effect of CCK-33 on Prolactin and Apomorphine-Induced Growth Hormone Secretion in Man

Nair¹,

S²,

Lizondo³

et al. 1983

Horm Metab Res

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Effect of domperidone on apomorphine-induced growth hormone secretion in normal men

Cited by 32 publications

References 44 publications

Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers

Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers

Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit

Effect of CCK-33 on Prolactin and Apomorphine-Induced Growth Hormone Secretion in Man

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