Effect of dobutamine on extravascular lung water index, ventilator function, and perfusion parameters in acute respiratory distress syndrome associated with septic shock

Zhou, Min; Dai, Ji; Du, Min; Wang, Wei; Chang-xing, Guo; Wang, Yi; Tang, Rui; Xu, Fei; Rao, Zhuqing; Sun, Guibo

doi:10.3109/21691401.2015.1052470

Cited by 4 publications

(2 citation statements)

References 32 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the early administration of medication reduced the 28-day mortality, improved the shock reversal rate, shortened the ICU stay, and decreased the duration of mechanical ventilation. Further, a prospective study by Zhou showed that in the early stage of acute respiratory distress syndrome caused by septic shock, dobutamine increased the cardiac output, reduced pulmonary edema in patients and reduced the required dose of norepinephrine ( 24 ). Fink et al confirmed that dobutamine can improve liver function and hepatic microcirculation in septic shock ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Early administration of dobutamine in the treatment of septic shock patients with tumor-a retrospective comparative cohort study

Wu¹,

Yin²,

Tang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background Studies have found that dobutamine may be beneficial to protect organs function in patients with septic shock, but there is still a lack of relevant research in septic shock patients with tumor. The study sought to explore the role of the early administration of dobutamine in the treatment of septic shock patients with tumors. Methods We retrospectively collected the data of tumor patients who developed septic shock at Sun Yat-sen University Cancer Center between June 2008 and November 2021. All the patients were divided into the following 3 groups: (I) the early administration group (<3 days, n=15); (II) the late administration group (≥3 days, n=22); and (III) the non-administration group (n=85). The primary observation indicator was 28-day mortality, and the secondary observation indicators included the shock reversal rate, the length of stay in the intensive care unit (ICU) and the duration of mechanical ventilation. There was no statistical difference in the basic data of the three groups. Results The early administration group had a significant decrease in 28-day mortality compared to the late and non-administration groups (log-rank P=0.018). The comparison between the groups showed that the 28-day mortality of the early administration group was significantly lower than that of the non-administration group [20.0% vs. 58.8%, P=0.013, hazard ratios (HRs) =0.248, 95% confidence intervals (CIs): 0.077–0.796]. There was no statistically significant difference in 28-day mortality between the late administration group and the non-administration group (63.6% vs. 58.8%, P=0.682, HR =0.983, 95% CI: 0.543–1.778). Additionally, the early administration group had a significantly increased shock reversal rate (P=0.014), shortened length of stay in the ICU (P<0.001), and reduced duration of mechanical ventilation (P=0.049). Conclusions Early use of dobutamine may be beneficial to reduce the in-hospital mortality of septic shock patients with tumor, but the sample size of this study was small, which still needs to be confirmed by a multi-center randomized controlled clinical study.

show abstract

Section: Discussionmentioning

confidence: 99%

Early administration of dobutamine in the treatment of septic shock patients with tumor-a retrospective comparative cohort study

Wu¹,

Yin²,

Tang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Dobutamine (DBT) [1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (±)-] is a beta-1 adrenergic agonist and was first developed as a structural analogue of isoprenaline [20] . DBT revealed that during the early stage of septic shock-induced ARDS, DBT treatment indicated a beneficial effect by relieving pulmonary edema in patients [21] . DBT was also shown to be effective for renal function parameters and it was well tolerated and elicited few side effects, thus, DBT appears to be used safely [22] .…”

Section: Introductionmentioning

confidence: 98%

Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study

Bolelli

Ertan-Bolelli

Ünsalan

et al. 2021

Journal of Molecular Structure

View full text Add to dashboard Cite

Highlights Fenoterol and dobutamine inhibit COVID-19 main protease (6W63). Docking study showed that fenoterol docked better than dobutamine. Fenoterol and dobutamine may be used in treatment of COVID-19. These compounds were extracted from ZINC database against COVID-19. Virtual screening approach helped to find two FDA approved drugs.

show abstract

Critical Care in the Severely Burned

Culnan¹,

Sherman

Chung

et al. 2018

Total Burn Care

View full text Add to dashboard Cite

Effect of dobutamine on extravascular lung water index, ventilator function, and perfusion parameters in acute respiratory distress syndrome associated with septic shock

Cited by 4 publications

References 32 publications

Early administration of dobutamine in the treatment of septic shock patients with tumor-a retrospective comparative cohort study

Early administration of dobutamine in the treatment of septic shock patients with tumor-a retrospective comparative cohort study

Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study

Critical Care in the Severely Burned

Contact Info

Product

Resources

About