1989
DOI: 10.1002/pros.2990150206
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Effect of DMSO and DFMO on rat prostate tumor growth

Abstract: An anaplastic, metastatic subline of the Dunning rat tumor was exposed to non-cytodestructive doses of the cellular differentiation agents dimethylsulfoxide and difluoromethylornithine. Copenhagen rats hosting prostate tumors were evaluated by comparing solid tumor growth resulting from injection of treated cells with solid tumor growth of untreated control cells. Results showed significantly slower solid tumor growth after a 15 day in vitro exposure of cells to either agent, after oral treatment of host anima… Show more

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Cited by 9 publications
(7 citation statements)
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References 23 publications
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“…The rationale for differentiation therapy in prostate cancer is supported by several lines of evidence. First, prostatic cancer growth and differentiation can be altered by various differentiating agents, including retinoids [Slawin et al, 1991;Pollard et al, 1991;Dahiya et al, 1995], dimethylsulfoxide (DMSO) [Carvalho et al, 1989;Kaneski et al, 1991], butyrate [Figg et al, 1994], and phenylacetate [Samid et al, 1993]. For example, noncytotoxic doses of DMSO reduce Dunning rat prostate cancer cell growth rates [Carvalho et al, 1989;Kaneski et al, 1991], while fenretinide inhibits carcinogenesis and metastases in Lobund-Wistar rats [Pollard et al, 1991] as well as tumor incidence and growth of rasϩmyc-induced carcinomas in the mouse prostate reconstitution model [Slawin et al, 1991].…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…The rationale for differentiation therapy in prostate cancer is supported by several lines of evidence. First, prostatic cancer growth and differentiation can be altered by various differentiating agents, including retinoids [Slawin et al, 1991;Pollard et al, 1991;Dahiya et al, 1995], dimethylsulfoxide (DMSO) [Carvalho et al, 1989;Kaneski et al, 1991], butyrate [Figg et al, 1994], and phenylacetate [Samid et al, 1993]. For example, noncytotoxic doses of DMSO reduce Dunning rat prostate cancer cell growth rates [Carvalho et al, 1989;Kaneski et al, 1991], while fenretinide inhibits carcinogenesis and metastases in Lobund-Wistar rats [Pollard et al, 1991] as well as tumor incidence and growth of rasϩmyc-induced carcinomas in the mouse prostate reconstitution model [Slawin et al, 1991].…”
mentioning
confidence: 99%
“…First, prostatic cancer growth and differentiation can be altered by various differentiating agents, including retinoids [Slawin et al, 1991;Pollard et al, 1991;Dahiya et al, 1995], dimethylsulfoxide (DMSO) [Carvalho et al, 1989;Kaneski et al, 1991], butyrate [Figg et al, 1994], and phenylacetate [Samid et al, 1993]. For example, noncytotoxic doses of DMSO reduce Dunning rat prostate cancer cell growth rates [Carvalho et al, 1989;Kaneski et al, 1991], while fenretinide inhibits carcinogenesis and metastases in Lobund-Wistar rats [Pollard et al, 1991] as well as tumor incidence and growth of rasϩmyc-induced carcinomas in the mouse prostate reconstitution model [Slawin et al, 1991]. Second, when androgens are used as differentiation agents and replaced intermittently after castration, repeated cycles of androgen-induced differentiation and androgen withdrawal-induced PSA nadirs are possible, and the time to androgen independence is delayed [Akakura et al, 1993;Sato et al, 1996].…”
mentioning
confidence: 99%
“…Historically, DMSO has been shown to have multiple effects on cellular functioning [ 55 ]. Its most noteworthy trait includes its ability to induce differentiation in malignant tumor cells at low doses, resulting in a loss of tumorigenicity and altered cell morphology into more mature, differentiated cells in leukemias, colon, prostate, lung, and breast carcinomas [ 56 58 ]. The exact mechanism of DMSO’s ability to induce differentiation remains relatively unknown; however, a study performed by Iwatani et al suggests DMSO impacting a cell’s epigenetic profile.…”
Section: Discussionmentioning
confidence: 99%
“…employed a cultured medium for freezing isolated MSCs from rat's bone marrow, in addition to a 10% fetal calf serum and a 5% DMSO. [ 138 ] Other researchers have employed a similar solution composition to cryopreserve human MSCs isolated from the bone marrow. Pal et al.…”
Section: Applications Of Cryopreservationmentioning
confidence: 99%