Effect of Distal Gastrectomy on Gut Hormone Release following Vagal Stimulation in Dogs

Kameyama, J; Suzuki, Airi; Yasaku, Y; Kuzu, Hiroshi; Tsukamoto, Masuhisa

doi:10.1159/000129306

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…This procedures takes advantage of intestinal peristalsis and the tolerance of the jejunum to acidic gastric juice and alkaline digestive juice. Kameyama et al first reported that the interposition of a jejunal pouch could preserve storage capacity in the remnant stomach (9). Katai et al reported that the incidence of reflux symptoms after jejunal interposition was 5.6%, and that of reflux esophagitis on endoscopy was 1.7%, which significantly improved the patients' postoperative quality Jejunal interposition: a segment of jejunum is inserted between the esophagus and the remnant stomach to construct an antireflux barrier.…”

Section: Jejunal Interpositionmentioning

confidence: 99%

Cardia function-preserving surgery and anti-reflux anastomotic method after proximal gastrectomy for gastric cancer: Current status and future perspectives

Liu

Cai

et al. 2022

Front. Oncol.

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The incidence and mortality of gastric cancer ranked 5th and 3rd worldwide, respectively, in 2018, and the incidence of gastroesophageal junction adenocarcinoma increased over the past 40 years. Radical resection and lymph node dissection is the preferred treatment for gastric cancer. Proximal gastrectomy or total gastrectomy is usually performed for gastroesophageal junction adenocarcinoma and upper gastric cancer. Owing to the resection of the cardia structures, the incidence of reflux esophagitis increases significantly after proximal gastrectomy and total gastrectomy, resulting in poor postoperative quality of life. To reduce the incidence of reflux esophagitis and improve patients’ postoperative quality of life, various methods to preserve the function of the cardia or to perform anti-reflux reconstruction have emerged. In this manuscript, we systematically introduced the advantages and problems of various anti-reflux anastomotic method after proximal gastrectomy, and cardia-preserving gastrectomy including endoscopic resection (ER), local gastrectomy by gastroscopy combined with laparoscopy, segmental gastrectomy, subtotal gastrectomy, and cardia-preserving radical gastrectomy. Cardia-preserving radical gastrectomy has the advantage of more thorough lymph node dissection and wider indications than those for subtotal gastrectomy. However, the clinical efficacy of cardia-preserving radical gastrectomy requires verification in prospective and controlled clinical trials. Cardia-preserving radical gastrectomy is a promising approach as one of the more reasonable anti-reflux surgeries.

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Section: Jejunal Interpositionmentioning

confidence: 99%

Cardia function-preserving surgery and anti-reflux anastomotic method after proximal gastrectomy for gastric cancer: Current status and future perspectives

Liu

Cai

et al. 2022

Front. Oncol.

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“…Beim Menschen bewirkt Scheinfu È tterung einen prompten Anstieg der PP-Sekretion, die vagal stimuliert wird [37,28]. Nach Gastrektomie ist die Gesamtsekretion von PP deutlich reduziert, was mit den fehlenden vagalen Reizen nach Gastrektomie erkla Èrt werden kann [1,9,39]. In der klinischen Studie von Friess et al [9] ist der PP-Basalwert nach Gastrektomie um 61% und die PP-Gesamtsekretion um 42% niedriger.…”

Section: Pp Wird Von Den In Den Langerhansschen Inseln Und Im Exokrinunclassified

Veränderungen im gastrointestinalen Hormonhaushalt nach Gastrektomie: Was ist klinisch relevant?

2000

Visc Med

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Changes of Gastrointestinal Hormone Balance after Gastrectomy: What Is Clinically Relevant? After total gastrectomy, the gastrointestinal hormones insulin, GIP and cholecystokinin show a significant increase. However, there is a decrease in the basal concentrations and the total secretions of gastrin, pancreatic polypeptide, motilin and secretin. The changes of gastrointestinal hormone balance are clinically relevant because of the disturbance of blood sugar regulation, the development of an exocrine insufficiency of the pancreas, and an increased frequency of steatorrhea. The correct choice of the type of reconstruction after gastrectomy significantly influences the balance of gastrointestinal hormones. The preservation of the duodenal passage is important. This can be attained if the disturbance of blood sugar regulation is prevented and the rate of steatorrhea is diminished. However, a pouch reconstruction alone does not significantly influence the gastrointestinal hormone balance.

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Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia

Holtmann

Goebell

Jockenhoevel

et al. 1998

Gut

123

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.05 versus all others). In healthy controls and patients with functional dyspepsia, insulin hypoglycaemia significantly (p<0.001) increased plasma PP levels. However, only two out of seven patients with functional dyspepsia had a more than twofold increase in PP values whereas all healthy controls had a more than twofold increase in PP levels after insulin hypoglycaemia (p<0.05). In contrast, there was no significant PP response in the gastrectomised patients (median 2%, range −10 to +23%). PP responses and visceral sensory thresholds were significantly correlated (r=0.65, p<0.002). Conclusions-The diminished PP response after insulin hypoglycaemia indicates disturbed eVerent vagal function in a subgroup of patients with functional dyspepsia. The data also suggest that the intact vagal nerve may exert an antinociceptive visceral eVect. (Gut 1998;42:501-506)

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Effect of Distal Gastrectomy on Gut Hormone Release following Vagal Stimulation in Dogs

Cited by 3 publications

References 2 publications

Cardia function-preserving surgery and anti-reflux anastomotic method after proximal gastrectomy for gastric cancer: Current status and future perspectives

Cardia function-preserving surgery and anti-reflux anastomotic method after proximal gastrectomy for gastric cancer: Current status and future perspectives

Veränderungen im gastrointestinalen Hormonhaushalt nach Gastrektomie: Was ist klinisch relevant?

Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia

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