1975
DOI: 10.1159/000231411
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Effect of Disodium Cromoglycate on Lymphocyte Response to Antigen and Mitogen

Abstract: The effect of disodium cromoglycate (DSCG) on the three following in vitro correlates of cell-mediated immunity has been studied: (1) Transformation of human peripheral blood lymphocytes after stimulation by an antigen, purified protein derivative and a mitogen, phytohaemagglutinin; (2) release of macrophage migration inhibitory factor, and (3) cytotoxic factor production, from these stimulated lymphocytes. At two non-toxic concentrations DSCG did not inhibit these three lymphocyte functions. These results sug… Show more

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Cited by 4 publications
(1 citation statement)
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“…To our knowledge this compound has not previously been investigated in an animal model of colitis. However, experiments have investigated the action of DSCG on in vitro correlates of cell-mediated immunity and have shown it to be without modulatory properties [18]. In addition, in vivo studies in guinea-pigs have examined the ability of DSCG to inhibit the 24 h delayed-type hypersensitivity skin reaction and found it to be devoid of any activity in doses up to 1 mg/kg i.v.…”
Section: Discussionmentioning
confidence: 99%
“…To our knowledge this compound has not previously been investigated in an animal model of colitis. However, experiments have investigated the action of DSCG on in vitro correlates of cell-mediated immunity and have shown it to be without modulatory properties [18]. In addition, in vivo studies in guinea-pigs have examined the ability of DSCG to inhibit the 24 h delayed-type hypersensitivity skin reaction and found it to be devoid of any activity in doses up to 1 mg/kg i.v.…”
Section: Discussionmentioning
confidence: 99%