Effect of Disinfectants on Antibiotics Susceptibility of Pseudomonas aeruginosa

Abstract

Disinfectants are widely used to get rid of microorganisms whether in hospitals, health centers or for normal domestic use. Some suggested that when disinfectants are incorrectly diluted the disinfectant might promote the growth of antibiotic-resistant bacteria, therefore, in this study pathogenic bacterium (Pseudomonas aeruginosa), isolated from patient with urinary tract infection, treated with two locally popular disinfectants (Claradone and Sarttol). Results showed that the bacterial growth was affected by both disinfectants. The lowest concentration of Claradone that inhibit the growth of this bacterium is considered as the minimum inhibitory concentration (MIC), this was 30%, while the lowest effecting concentration of Sarttol was 3%. A number of survival colonies after treated with high concentration of Calarodone and Sarttol were investigated for their susceptibility to antibiotics, using standard disc diffusion method. Results indicated that these colonies of P. aeruginosa resisted antibiotics they were sensitive to before treatment. So it can be concluded that using Claradone and sarttol can make the pathogenic bacterium (P. aeruginosa) resist some antibiotics.

The use of minimum selectable concentrations (MSCs) for determining the selection of antimicrobial resistant bacteria

“…In this study, growth-rate data were applied to determine minimal selective concentrations of disinfectants which lead to increased resistance traits. It has been considered that the disinfectant resistance could enhance antibiotic resistance in environment and contribute to increased public health risk (Al-Jailawi et al 2013 ; Capita et al 2014 ; Seier-Petersen et al 2014 ).…”

Characterization of antibiotic and disinfectant susceptibility profiles amongPseudomonas aeruginosaveterinary isolates recovered during 1994-2003

“…; Al‐Jailawi et al . ). This study was designed to characterize the antibiotic and disinfectant susceptibility profiles among Ps.…”

“…Ciprofloxacin is a very potent antimicrobial used in human medicine (Bergan et al 1988), and increased multidrug-resistant pathogens are a concern in both human and veterinary medicine (Cohen et al 1991;Hartmann et al 1997). Reports also have suggested increasing resistance of bacteria to biocides (McDonnell and Russell 1999;Russell 2002), that sublethal concentrations of food-grade biocides influenced formation of biofilms and antimicrobial resistance (Capita et al 2014) and that biocide use resulted in cross-resistance to antibiotics (Maris 1991;Sidhu et al 2002a;Braoudaki and Hilton 2004;Beier et al 2005;Al-Jailawi et al 2013). This study was designed to characterize the antibiotic and disinfectant susceptibility profiles among Ps.…”

Disinfectant and Antimicrobial Susceptibility Profiles of Campylobacter coli Isolated in 1998 to 1999 and 2015 from Swine and Commercial Pork Chops

“…The emergence of multidrug-resistant pathogens worldwide as well as a lack of new drug development is a concern in both human and veterinary medicine (CDC, 2013;Ventola, 2015). Research studies show that there is bacterial resistance to biocides (Davin-Regli & Pagès, 2012;Maillard, 2007;Russell, 2002;Slipski, Zhanel, & Bay, 2018;Tumah, 2009), and biocide use has resulted in cross-resistance to antimicrobials (Al-Jailawi, Ameen, & Al-Jeboori, 2013;Beier, Bischoff, Ziprin, Poole, & Nisbet, 2005;Braoudaki & Hilton, 2004;Davin-Regli & Pagès, 2012;Gnanadhas, Marathe, & Chakravortty, 2013;Maris, 1991;Romaro, Burgos, Pérez-Pulido, Gálvez, & Lucas, 2017;Sidhu, Heir, Leegaard, Wiger, & Holck, 2002;Wales & Davies, 2015;Wand, Bock, Bonney, & Sutton, 2017) producing a real risk that increased biocide use may exacerbate the trend of increasing AMR in pathogenic organisms (Fraise, 2002).…”