Effect of discarded keratin-based biocomposite hydrogels on the wound healing process in vivo

Park, Soo‐Jin; Shin, Hyung Shik; Kim, Byoung‐Suhk; Kim, Myung Jin; Kim, In-Shik; Park, Byung-Yong; Kim, Hee Young

doi:10.1016/j.msec.2015.03.033

Cited by 74 publications

(35 citation statements)

References 33 publications

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“…Differences in epithelization observed in the FKDP‐dressed vs. control wounds indicate that dressing accelerated epithelial cells migration and proliferation. Similar results were reported in a porcine full‐thickness skin wound model using commercial dressings Keragel and Keramatrix (Keraplast Technologies, San Antonio, TX), and in the rat full‐thickness skin wound model . These results show that keratin‐derived biomaterials tested on different animal models support favorable conditions for healing and tissue recovery.…”

Section: Discussionsupporting

confidence: 80%

“…Similar results were reported in a porcine full-thickness skin wound model 25 using commercial dressings Keragel and Keramatrix (Keraplast Technologies, San Antonio, TX), and in the rat full-thickness skin wound model. 26,27 These results show that keratin-derived biomaterials tested on different animal models support favorable conditions for healing and tissue recovery. Nevertheless, the dressings employed in these models were prepared using more complex procedures and employed further chemical modifications leading to preparation of water-soluble keratin.…”

Section: Discussionmentioning

confidence: 75%

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The role of allogenic keratin‐derived dressing in wound healing in a mouse model

Konop

Sulejczak

Czuwara

et al. 2017

Wound Repair Regeneration

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Keratin is an interesting protein needed for wound healing and tissue recovery. We have recently proposed a new, simple and inexpensive method to obtain fur and hair keratin-derived biomaterials suitable for medical application. The aim of the study was to evaluate the role of the fur keratin-derived protein (FKDP) dressing in the allogenic full-thickness surgical skin wound model. The data obtained using scanning electron microscopy showed that employed processed biomaterial had higher surface porosity compared with control raw material. From the MTS test, it was found keratin biomaterial is not only toxic to the NIH/3T3 cell line (p < 0.05), but also enhances cell proliferation compared with the control. In vivo studies have shown keratin dressings are tissue biocompatible, accelerate wound closure and epithelialization to the statistically significant differences on day 5 (p < 0.05) in comparison to control wounds. Histological examination revealed, that in FKDP-treated wounds the inflammatory response contained predominantly macrophages whilst their morphological untreated variants showed mixed cell infiltrates rich in neutrophils. Predominant macrophages based response creates more favorable environment for healing. In FKDP-dressed wounds the number of microhemorrhages was also significantly decreased (p < 0.05) as compared with undressed wounds. Applied keratin dressing favors reconstruction of a more regular skin structure and assures better cosmetic effect in terms of scar formation and appearance. In conclusion, fur keratin-derived protein dressings significantly accelerated wound healing in the mouse model. Further studies are needed to determine the molecular mechanisms involved in the multilayer wound healing process and to assess the possible use of these dressings for medical purposes.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 75%

The role of allogenic keratin‐derived dressing in wound healing in a mouse model

Konop

Sulejczak

Czuwara

et al. 2017

Wound Repair Regeneration

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“…Keratin scaffolds achieved earlier vascularization and better skin repair compared with the self-healing process of full-thickness wounds. Park et al 121 prepared keratin-based hydrogels that were shown to augment the process of excision wound healing by increasing collagen synthesis during the wound healing process in vivo . Scaffolds of human hair proteins were fabricated by Verma et al 122 and studies show that these scaffolds have the capability to enhance cell–cell contacts with LDV-mediated cell-matrix contacts and support long-term cell culture.…”

Section: Natural Proteins As Carriers For Drug Delivery and Tissue Enmentioning

confidence: 99%

Biomacromolecules as carriers in drug delivery and tissue engineering

Zhang

Sun

Jiang

2018

Acta Pharmaceutica Sinica B

315

178

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Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability, nontoxicity, biocompatibility, biodegradability, long blood circulation time and targeting ability. Recent advances in our understanding of the biological functions of natural-origin biomacromolecules and the progress in the study of biological drug carriers indicate that such carriers may have advantages over synthetic material-based carriers in terms of half-life, stability, safety and ease of manufacture. In this review, we give a brief introduction to the biochemical properties of the widely used biomacromolecule-based carriers such as albumin, lipoproteins and polysaccharides. Then examples from the clinic and in recent laboratory development are summarized. Finally the current challenges and future prospects of present biological carriers are discussed.

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“…The gel forming may be assigned not only to the physical interaction between S-sulfo keratin chains, oxygen groups in PVA aqueous solution and the amine groups of PEI, but also to the keratin covalent crosslinking by EBI. Later, these hydrogels have been tested for wound healing [393] and was suggested that the treatment with these keratin-based hydrogels enhanced the production of new collagen and fibroblast proliferation during granulation tissue formation and the remodeling phase of wound healing. Synthetic polymers as PEGDA [394], PVA [395], poly(N-hydroxyethyl acrylamide) (PHEA) [396], PAAm [397] etc., were used in combination with silk sericin to obtain hybrid hydrogels that could be used especially for wound dressings and dermal reconstructions.…”

Section: Wound Healingmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

195

131

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New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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Effect of discarded keratin-based biocomposite hydrogels on the wound healing process in vivo

Cited by 74 publications

References 33 publications

The role of allogenic keratin‐derived dressing in wound healing in a mouse model

The role of allogenic keratin‐derived dressing in wound healing in a mouse model

Biomacromolecules as carriers in drug delivery and tissue engineering

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

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