Effect of Diphenylhydantoin Treatment on the Release of Corticotrophin in Epileptic Patients

Rinne, U. K.

doi:10.1159/000103979

Cited by 10 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three of the five patients in whom the metyrapone test gave a pathological result were receiving diphenylhydantoin. It has been shown that diphenylhydantoin may diminish or block the response to metyrapone (Krieger 1962, Rinne 1966. It is therefore probable that the diphenylhydantoin treatment had contributed to the pathological response in these cases.…”

Section: Resultsmentioning

confidence: 96%

Hypothalamo-Pituitary-Adrenal Function Following Subarachnoid Hemorrhage

Osterman

2009

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

The endocrine function was evaluated in 50 patients a minimum of 3.5 months after a subarachnoid hemorrhage. The hypothalamopituitary‐adrenal function was assessed by studying the circadian rhythm of plasma 11‐hydroxycorticosteroids and with the metyrapone test. In addition, screening methods were used to evaluate thyroid and gonadal functions. The results indicate that hypothalamo‐pituitaryadrenal disturbances may occur in patients surviving a subarachnoid hemorrhage. In patients who have survived a subarachnoid hemorrhage more than 3.5 months, however, frank hypopituitarism is rare.

show abstract

Section: Resultsmentioning

confidence: 96%

Hypothalamo-Pituitary-Adrenal Function Following Subarachnoid Hemorrhage

Osterman

2009

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…Similarly, a DPH-induced reduction in calcium-stimulated CT secretion in vitro has been observed (Pento arui Orme, unpubJished observation). It has also been reported that basal function of the pituitary-adrenal axis is normal in DPH-treated epileptics; however, stimulated ACTH release is reduced (Rinne 1966).…”

Section: Discussionmentioning

confidence: 94%

“…In addition, DPH has been shown to influence the regulation and secretion of a number of endocrines such as adrenocorticotropin (ACTH) (Krieger 1962, Rinne 1966, antidiuretic hormone (ADH) (Fichman, Kleeman and Bethune 1970) and insulin (Peters and Samaan 1969, Kizer, Vargas-Cordan, Brendel and Bressler 1970. Similarly, in a previous study a DPHinduced inhibition of calcium-and glucagon-stirnulated calcitonin (CT) secretion was observed (Pento, GUck and Kagan 1973a).…”

Section: Introductionmentioning

confidence: 83%

Diphenylhydantoin Inhibition of Pentagastrin-Stimulated Calcitonin Secretion in the Pig

Jt¹

1976

Horm Metab Res

View full text Add to dashboard Cite

The present study examined the influence of diphenylhydantoin (DPH) on pentagastrin-induced calcitonin (CT) secretion in the pig. Diphenylhydantoin was observed to slow the onset and prolong the duration of pentagastrin stimulation on CT secretion. Further, pentagastrin reduced plasma calcium in both the control and DPH treated groups. The results of this study indicate a significant DPH-induced inhibition of pentagastrin-stimulated CT secretion in the pig.

show abstract

Hydantoins

Jones¹,

Wimbish²

1985

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

Effect of Diphenylhydantoin Treatment on the Release of Corticotrophin in Epileptic Patients

Cited by 10 publications

References 12 publications

Hypothalamo-Pituitary-Adrenal Function Following Subarachnoid Hemorrhage

Hypothalamo-Pituitary-Adrenal Function Following Subarachnoid Hemorrhage

Diphenylhydantoin Inhibition of Pentagastrin-Stimulated Calcitonin Secretion in the Pig

Hydantoins

Contact Info

Product

Resources

About