Effect of Digitalis Administration on Experimental Hypertrophy.

Schwab, Edward H.; Herrmann, G

doi:10.3181/00379727-36-9419p

Cited by 4 publications

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“…And the foxglove ( Digitalis purpurea ) is said to have diuretic properties benefiting dropsy 2 . Digitalis improves cardiac output by neurohumoral and interrelated mechanisms on the cardiac, vascular and autonomic nervous systems 1–32 (Figure 1). Digitalis can:…”

Section: Figurementioning

confidence: 99%

“… improve atrial natriuretic peptide (ANP) responsiveness to increase left atrial and ventricular pressures – a ‘preload’ modulation 2,3,22,29 reduce renin‐angiotensin vasopressor effects indirectly or via baroreceptor reflex mechanisms – an ‘afterload’ effect improve beta‐receptor responsiveness and induce sodium potassium pump release of intracellular calcium for contraction or ‘inotropy’ 1–3,10,23,29 attenuate growth factors and collagen for improving compliance – a ‘lusitropic’ effect 5,14–23,29 increase vagal tone – a negative ‘chronotropic’ effect to provide ‘synergistic’ rate control in atrial fibrillation (AF) and reduce pulmonary congestion in diastolic dysfunction situations 1–3 …”

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confidence: 99%

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The Old but Reliable Digitalis: Persistent Concerns and Expanded Indications

2001

Int J Clinical Practice

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SUMMARYDigitalis has been an old but reliable drug for 240 years. Concerns regarding its clinical indications and benefits still exist in the absence of a reduction in all‐cause mortality. While intravenous digitalis is used without question in cases of atrial fibrillation, it is still controversial in sinus rhythm, despite the Digitalis Investigation Group (DIG) study showing a significant reduction in death and the need for hospitalisation for congestive heart failure in both diastolic and systolic dysfunction. The influence of digitalis in acute myocardial infarction, coronary artery disease and sudden cardiac death remains speculative. In cases of uncomplicated hypertension, it appears to prevent the onset of left ventricular dysfunction and myocardial infarction. Thus, digitalis can be a cost‐effective agent with added benefits.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

The Old but Reliable Digitalis: Persistent Concerns and Expanded Indications

2001

Int J Clinical Practice

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“…Although there is experimental evidence to support the "proReceived for publication 9 December 1974 and in revised form 17 March 1975. phylactic" use of glycosides (1)(2)(3)(4), results of these studies have not been sufficiently convincing to generate or justify widespread clinical acceptance of this use of digitalis. Furthermore, Katz has raised the theoretical possibility that maintenance of glycoside-induced positive inotropism in nonfailing myocardium for an extended period may be detrimental (5).…”

Section: Introductionmentioning

confidence: 99%

The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium.

Williams¹,

Potter²

1975

J. Clin. Invest.

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A B S T R A C T To determine the effect of prolonged digitoxin administration on contractile function of nonfailing myocardium, right ventricular papillary muscle mechanics were examined after 6 or 24 wk of glycoside administration to control and pulmonary artery banded cats. Resting length-tension relations were not affected by digitoxin; however, isometrically developed force and the maximal rate of force development at the peak of the length-tension curve were increased in all treated groups.In untreated animals, banding resulted in a 28% incidence of deaths from heart failure. 6 wk after constriction, contractile function was depressed whereas normal function was observed 24 wk after banding. Digitoxin significantly reduced mortality from heart failure and enhanced the recovery of contractile function; contractile function in the 6 wk banded treated group approached that of untreated control and 24-wk banded groups. The long-term effects of digitoxin on contractile function were not importantly related to the temporal association between banding and institution of glycoside administration. Development of myocardial hypertrophy was comparable in treated and untreated banded groups.These results demonstrate that a significant positive inotropic effect persists in both normal and nonfailing hypertrophied myocardium during chronic digitoxin administration.

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Digitalis in non-failing cardiac diseases

Kassebaum

Griswold

1970

Progress in Cardiovascular Diseases

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Effect of Digitalis Administration on Experimental Hypertrophy.

Cited by 4 publications

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The Old but Reliable Digitalis: Persistent Concerns and Expanded Indications

The Old but Reliable Digitalis: Persistent Concerns and Expanded Indications

The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium.

Digitalis in non-failing cardiac diseases

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