Effect of Diflubenzuron (Dimilin; TH—6040) on the Hyaluronic Acid Concentration in Chicken Combs ,

Abstract

The addition of N-[[(4-chlorphenyl)amino]carbonyl]-2,6-difluorobenzamide(diflubenzuron; Dimilin; TH-6040) up to levels of 250 ppm of the total diet of both male broilers and layers for 98 days did not affect the hyaluronic acid (HA) concentration (microgram/g tissue) in the combs. The concentration was measured at 21, 28, 42, 56, and 98 days on feed. The concentration in the combs of the layers were not significantly different at any sampling period regardless of diet. At the end of 56 days on feed, the combs of the broiler controls had a significantly (P less than .025) higher concentration than did any of the groups fed diflubenzuron. There were no differences observed at 21, 28, 42, or 98 days in the broilers. The HA concentration increased as the chickens matured and became larger; however, large variations were observed within the various groups at a given sample period.

Chitin synthesis inhibitors: Effects on insects and on nontarget organisms

“…29 Feeding diflubenzuron to growing chickens at the same levels did not affect body, testes, liver, comb, and feet weights. No significant effects on body weight gain, egg production, fertility, and hatchability were observed 30 -31 when two breeds of laying hens were fed 10|xg/g diflubenzuron for 15 weeks.…”

Toxicology of insecticides to mammals

“…The chitin synthesis inhibitors include the benzoylureas, diflubenzuron, lufenuron and hexaflumuron and a chemically different compound, buprofezin. Diflubenzuron, the most studied compound of the group, does not appear to inhibit hexosamine transferases, which are required for glycosaminoglycan formation in vertebrates 42–45. The acute toxicity of the benzoylureas is low, while the repeated‐dose toxicity in experimental animals is dominated by effects on the blood, probably mediated through aniline metabolites (see the review by Marrs46).…”

The Influence of Diflubenzuron on Several Weight Characteristics in Growing Male Broiler and Layer Chickens

“…Miller et al (1976) observed no significant effects on body weight gain, egg production, fertility, or hatchability when two breeds of laying hens were fed 10 ppm diflubenzuron for 15 weeks. Crookshank et al (1978) showed that feeding diflubenzuron for 98 days at levels up to 250 ppm did not affect the hyaluronic acid content of combs of male broiler or layer chickens. There is not adequate information in the literature on the effects of diflubenzuron ingestion by poultry.…”