Effect of different ventilation modes with FC‐77 on pulmonary inflammatory reaction in piglets after cardiopulmonary bypass

Jiang, Lijun; Wang, Qiang; Liu, Yinglong; Du, Ming; Xiang‐dong, Shen; Xie, Ning; Song, Wu

doi:10.1002/ppul.20510

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…By contrast, studies in different lung-injury models generally showed a decrease in expression of several cytokines, such as IL-1β [23,25,27], IL-6 [27,71,73,74] and IL-8 [23,27,28,73,[85][86][87], in the PLVtreatment group compared with the respective GV-treatment group. By contrast, the effect of PLV with a PFC on TNF-α levels did not follow a consistent trend in the various animal studies [71,83,[88][89][90][91] and may depend on where TNF-α levels were assessed.…”

Section: Review Lehmlermentioning

confidence: 89%

“…A recent study demonstrated that TLV can be more effective at reducing pulmonary neutrophil infiltration than PLV [73]. Even systemic administration of PFCs, such as FC-77 administered intraperitoneally 48 h prior to lung injury, could decrease neutrophil infiltration in the lung [77].…”

Section: Anti-inflammatory Effects Of Pfcsmentioning

confidence: 97%

“…As mentioned earlier, in vivo studies have shown that liquid ventilation with PFCs protects the lung from acute inflammation by reducing the neutrophil infiltration in different lung-injury animal models [26, [64][65][66][67][68][69][70][71][72][73][74] and clinical studies [76]. Cell-adhesion molecules, such as integrins and selectins, are expressed by leukocytes, as well as endothelial and epithelial cells, and play an important role during acute lung injury by controlling the migration of inflammatory cells, in particular neutrophils, to the lung.…”

Section: Pfcs and Adhesion Molecules: Cell-culture Studiesmentioning

confidence: 99%

“…• Surfactant depletion is the most commonly employed model of lung injury (in addition, LPS [83,89], pneumonia [90], hydrochloric acid [91,93], acidified infant formula [72,75], hypotension and cardiac arrest [87], as well as cardiopulmonary bypass alone or plus LPS [73,74], have been studied as models of lung injury)…”

Section: Effect Of Plv With Pfcs On Cytokine Levels: Clinical Studiesmentioning

confidence: 99%

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Anti-inflammatory effects of perfluorocarbon compounds

Lehmler¹

2008

Expert Review of Respiratory Medicine

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Perfluorocarbon compounds (PFCs) are of interest for the treatment of acute lung injury due to unique physicochemical properties such as high solubility for oxygen. Different respiratory treatment modalities (e.g., liquid ventilation or aerosolized PFCs) have been shown to decrease pulmonary inflammatory responses in addition to improving lung compliance in animal models of lung injury and in clinical trials. Specifically, PFC-based treatment modalities have been shown to reduce levels of cytokines, chemokines and other mediators of pulmonary inflammation in a PFC- and, to some extent, concentration-dependent manner. As a result, neutrophil adhesion, accumulation and activation are reduced in PFC-treated animals and in humans undergoing partial liquid ventilation. Although more fundamental studies of the underlying anti-inflammatory mechanisms are needed, respiratory treatment modalities involving PFCs hold great clinical promise.

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Section: Review Lehmlermentioning

confidence: 89%

Section: Anti-inflammatory Effects Of Pfcsmentioning

confidence: 97%

Section: Pfcs and Adhesion Molecules: Cell-culture Studiesmentioning

confidence: 99%

Section: Effect Of Plv With Pfcs On Cytokine Levels: Clinical Studiesmentioning

confidence: 99%

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Anti-inflammatory effects of perfluorocarbon compounds

Lehmler¹

2008

Expert Review of Respiratory Medicine

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“…Beside positive effects on gas exchange, lung mechanics, and ventilation/perfusion matching, animals treated with liquid ventilation also exhibited attenuated pulmonary damage with concomitant reduction in pulmonary neutrophil sequestration (19,21,32,39). A clinical trial investigating PFC treatment in trauma patients with acute lung injury demonstrated reduced neutrophil counts and decreased levels of proinflammatory cytokines in bronchoalveolar lavage fluid (7).…”

mentioning

confidence: 99%

Leukocyte antibacterial functions are not impaired by perfluorocarbon exposure in vitro

Haufe¹,

Koenigshausen²,

Knels³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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Application of liquid, aerosolized, and vaporized perfluorocarbons (PFC) in acute lung injury has shown anti-inflammatory effects. Although this may be beneficial in states of pulmonary hyperinflammation, it also could increase susceptibility to nosocomial lung infection. We hypothesized that PFC impair cellular host defense and therefore investigated in an in vitro model the influence of perfluorohexane (PFH) on crucial mechanisms of bacterial elimination in human neutrophils and monocytes. Using scanning and transmission electron microscopy, we could show membrane-bound and ingested PFH particles that morphologically did not alter adherence and phagocytosis of Escherichia coli or leukocyte viability. The amount of adherent and phagocytosed bacteria as determined by flow cytometry was not influenced in cells only pretreated with PFH for 1 and 4 h. When PFH was present during E. coli challenge, bacterial adherence was decreased in polymorphonuclear neutrophils, but respective intracellular uptake was not impaired and was even significantly promoted in monocytes. Overall, E. coli-induced respiratory burst capacity was not reduced by PFH. Our findings provide evidence that key functions of innate host defense are not compromised by PFH treatment in vitro.phagocytosis; burst; perfluorohexane; anti-inflammatory; immune LIQUID VENTILATION WITH PERFLUOROCARBONS (PFC) has been successfully applied in experimental and human acute lung injury (18,20,27,36). Beside positive effects on gas exchange, lung mechanics, and ventilation/perfusion matching, animals treated with liquid ventilation also exhibited attenuated pulmonary damage with concomitant reduction in pulmonary neutrophil sequestration (19,21,32,39). A clinical trial investigating PFC treatment in trauma patients with acute lung injury demonstrated reduced neutrophil counts and decreased levels of proinflammatory cytokines in bronchoalveolar lavage fluid (7). Although removal of alveolar inflammatory exudate by dense, water-insoluble PFC probably contributes to mitigation of pulmonary hyperinflammation, a direct interference with immune cell function may also be involved. This proposition is supported by recent in vivo studies using aerosolized PFC in a surfactant-washout model that reported PFC to decrease mRNA expression of proinflammatory cytokines and adhesion molecules in lung tissue samples as well as in microdissected alveolar macrophages and pulmonary parenchymal cells (42,49,50). Further evidence for cellular anti-inflammatory effects of PFC is provided by in vitro experiments showing a decreased response of activated polymorphonuclear neutrophils (PMN) and monocytic cells in terms of cytokine secretion, chemotaxis, cyclooxygenase-2 (COX-2) expression, and NF-B activation (5,25,37,46,51). Liquid ventilation with PFC did not result in improved survival or reduced need for ventilatory support in recent multicenter trials of patients with acute respiratory distress syndrome (ARDS) (17, 24). Nevertheless, intrinsic anti-inflammatory properties of PFC might b...

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Preparation of inclusion complex of perfluorocarbon compound with β-cyclodextrin for ultrasound contrast agent

Yao

Liu

et al. 2015

RSC Adv.

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Effect of different ventilation modes with FC‐77 on pulmonary inflammatory reaction in piglets after cardiopulmonary bypass

Abstract: Both TLV and PLV improved oxygenation and reduced pulmonary inflammatory reaction in piglets after CPB, whereas TLV is more effective than PLV.

Cited by 7 publications

References 32 publications

Anti-inflammatory effects of perfluorocarbon compounds

Anti-inflammatory effects of perfluorocarbon compounds

Leukocyte antibacterial functions are not impaired by perfluorocarbon exposure in vitro

Preparation of inclusion complex of perfluorocarbon compound with β-cyclodextrin for ultrasound contrast agent

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