Effect of Different Types of Exercise in HIV + Mozambican Women Using Antiretroviral Therapy

Mangona, Lucília; Daca, Timóteo; Tchonga, Francisco; Bule, Odete; Bhatt, Nilesh; Jani, Ilesh; Damasceno, Albertino; Prista, António

doi:10.2174/1874613601509010089

Cited by 17 publications

(20 citation statements)

References 36 publications

(61 reference statements)

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“…In addition, Terry et al [74], included flexibility exercise. Seven (7) studies utilized Resistant exercises [36, 68–70, 73, 75, 77]. In addition, four studies [36, 68, 70, 77] included flexibility exercise.…”

Section: Resultsmentioning

confidence: 99%

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

et al. 2019

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Background Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release of heat shock protein, immune function alteration or reduced tissue hypoxia, have been highlighted as possible mechanisms by which increasing physical activity may reduce plasma pro-inflammatory cytokines in uninfected individuals and should be appraised in the literature for evidence of similar benefits in people living with HIV (PLWH). Therefore, we evaluated the effects of physical exercises on 1) inflammatory biomarkers and 2) cardiopulmonary function (VO 2 Max) in PLWH. Method A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to January 2018. Only randomized control trials investigating the effects of either aerobic or resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted with random effect models using the Review Manager (RevMan) computer software. Result Twenty-three studies met inclusion criteria ( n = 1073 participants at study completion) comprising male and female with age range 18–65 years. Three meta-analyses across three sub-groups comparisons were performed. The result showed no significant change in biomarkers of inflammation (IL-6 and IL-1β) unlike a significant (Z = 3.80, p < 0.0001) improvement in VO 2 Max. Overall, the GRADE evidence for this review was of moderate quality. Conclusion There was evidence that engaging in either aerobic or resistance exercise, or a combination of both exercises, two to five times per week can lead to a significant improvement in cardiopulmonary function but not biomarkers of inflammation (IL-6 and IL-1β). However, this should not be interpreted as “No evidence of effect” because the individual trial studies did not attain sufficient power to detect treatment effects. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate. Electronic supplementary material The online version of this article (10.1186/s12879-019-3960-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

et al. 2019

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“…After screening titles and application of the eligibility criteria, 21 studies (Baigis et al, 2002;Cade et al, 2003;Cade et al, 2013;Cutrono et al, 2015;Dolan et al, 2006;Ezema et al, 2014;Hand et al, 2008;Jaggers et al, 2014;MacArthur et al, 1993;Mangona et al, 2015;Mapstone et al, 2014;Mutimura et al, 2008;Neto et al, 2016;Oursler et al, 2009;Perna et al, 1999;Ramírez-Marrero et al, 2014;Raso et al, 2013;Smith et al, 2001;Sullivan et al, 2014;Terry et al, 2006;Thoni et al, 2002) were eligible for inclusion in the meta-analysis. (n=31) and sub-maximal (n=5) exercise tests.…”

Section: Search Results and Flow Of Studies Through The Reviewmentioning

confidence: 99%

Cardiorespiratory fitness levels and moderators in people with HIV: A systematic review and meta-analysis

Vancampfort

Mugisha

Rosenbaum

et al. 2016

Preventive Medicine

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Cardiorespiratory fitness (CRF) is a modifiable risk factor for cardiovascular disease and premature mortality. CRF levels and moderators among people living with HIV (PLWH) are unknown. The aim of the current meta-analysis was to (1) determine mean CRF in PLWH and compare levels with age-and gender-matched healthy controls (HCs), (2) explore moderators of CRF,3and (4) explore moderators of CRF outcomes following physical activity (PA) interventions. Major electronic databases were searched systematically for articles reporting CRF expressed as maximum or peak oxygen uptake (ml/min/kg) in PLWH. A random effects meta-analysis calculating the pooled mean CRF including subgroup-and meta-regression analyses was undertaken. Across 21 eligible studies, the CRF level was 26.4 ml/kg/min (95%CI=24.6 to 28.1) (n=1,010; mean age =41years). There were insufficient data to compare CRF levels with HCs. A higher body mass index (β=-0.99, 95%CI=-1.93 to -0.06, P=0.04), older age (β=-0.31, 95%CI=-0.58 to -0.04, P=0.02) and the presence of lipodystrophy (β=-4.63, 95%CI=-7.88 to -1.39, P=0.005) were significant moderators of lower CRF levels. Higher CD4+ counts (β=0.004, 95%CI=0.0007 to 0.007, P=0.016), supervised interventions (P<0.001) and interventions with a lower frequency of weekly sessions (2 or 3 versus 4 times) (P<0.001) predicted a better CRFoutcome following PA. CRF levels of PLWH are among the lowest in comparison to other vulnerable populations. More research on the most optimal physical activity intervention characteristics is needed.

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“… 32 Although research in these areas is limited, it is, however, apparent that therapeutic exercise is synchronously becoming an accepted alternative care modality for HIV/AIDS sufferers. 20 , 21 , 34 Figure 1 depicts the potential for transference and behavioral reinforcement, which a structured program of therapeutic exercise can elicit.…”

Section: Introductionmentioning

confidence: 99%

The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa

Daniels

Niekerk

2018

HIV

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IntroductionAttitudes, responses, and reactions of HIV-positive women in three sub-Saharan African regions toward a therapeutic exercise intervention, aimed to determine the presence of depression and low body self-image, were captured. This provided insight into body satisfaction and desire to exercise (Stage 1, n=60), body self-image and depression (Stage 2, n=60), and overall concerns around the often adverse side effects of antiretroviral treatment (ART). A program of therapeutic (specialty) exercise was developed for the experimental design (Stage 2), to quantify the psychological side effects of these variables.MethodologyStage 1 constituted a qualitative exploration into attitudes and perceptions around ART, toxicity, health concerns, metabolic irregularities (lipodystrophy), body shape and size dissatisfaction, and cultural attitudes toward exercise. This stage deployed brief informal face-to-face interviews, based on the World Health Organization (WHO)/United Nations Fund for Population Activities (UNFPA) AIDS Inventory, in three sub-Saharan African regions (including provincial and district hospitals, nongovernmental organizations, voluntary counseling and testing/HIV and testing centers, and primary care outpatient clinics). Stage 2 of the study comprised a quantitative experimental design, conducted on a sample of HIV-positive women (mean age=39.0 years; mean years on ART=5.5; 86% black) in three selected HIV outpatient clinics in Johannesburg, South Africa.Data analysisThe collated data sets from both stages of the research were presented, analyzed, and interpreted (thematic analyses [Stage 1] and statistical analyses [Stage 2]) using the body self-image questionnaire and Beck’s depression inventory.ResultsStage 1 outlined participants’ concerns and reports around 1) body shape and size, including long-term effects of ART and 2) attitudes toward exercise, as a function of HIV status. Stage 2 represented pre- and posttest statistics, showing low statistical means for both the experiment and the control groups, with statistical significance for four out of nine items of subscales of body self-image questionnaire.

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Effect of Different Types of Exercise in HIV + Mozambican Women Using Antiretroviral Therapy

Cited by 17 publications

References 36 publications

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis

Cardiorespiratory fitness levels and moderators in people with HIV: A systematic review and meta-analysis

The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa

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