Effect of Different Remineralizing Agents on White Spot Lesions

Abstract

AIM: This study evaluated the impact of two remineralizing agents containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and tricalcium phosphate (TCP) on white spot lesions.
 MATERIALS AND METHODS: A total of 90 freshly extracted upper premolars were divided in three equal groups (30 each): Group A: Control group, Group B: Varnish containing CPP-ACP, and Group C: Varnish containing TCP. The teeth were subjected to Diagnodent test after inducing white spot lesions to assess any surface changes present on the teeth. The readings were repeated post-demineralization and post-remineralization.
 RESULTS: Statistically significant difference was present in the mean values between the tested groups. CPP-ACP group recorded higher mean value at demineralization when compared to TCP group. Statistically significant difference (p < 0.00`01) was present between the baseline and the demineralization values. CPP-ACP group presented higher remineralization results when compared to TCP group. T-test proved a significant difference between the tested groups.
 CONCLUSION: CPP-ACP containing varnish had higher remineralizing effect when compared to TCP containing varnish.
 CLINICAL SIGNIFICANCE: Recently, the focus of restorative dentistry has been directed toward a conservative approach. Prevention and non-restorative treatment of initial enamel caries is the main concern. Remineralization procedures are the most preferred way of regeneration of lost tooth structure.

Combined Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Is Not Superior to Fluoride Alone in Early Carious Lesions: A Meta-Analysis

“…Casein phosphopeptide (CPP) is actually based on casein, a milk protein that binds and chelates calcium, providing the basis for its calcium phosphate donor capacity [Shen et al, 2018;Philip, 2019;Alhamed et al, 2020;Mekky et al, 2021]. CPP may serve as a saliva biomimetic compound with a great capacity of stabilizing calcium and phosphate, preventing the formation of poorly soluble phases and maintaining the bioavailability of ions to facilitate their precipitation on the enamel surface lesions and thus effectively inhibiting demineralization and enhancing remineralization [Cochrane and Reynolds, 2012;Ma et al, 2019;Alagha and Samy, 2021;Sbaraini et al, 2021]. The binding between CPP-ACP is pHdependent.…”

Remineralization potential and mechanical evaluation of a bioactive glass containing composite (An ex vivo study)

“…The remineralization of demineralized dentin is a process in which minerals are restored through inorganic minerallike materials formation. Calcium-based compounds were efficiently incorporated into dental restorations to enhance the healing of dental tissues [1], [2], [3].…”