2018
DOI: 10.11613/bm.2018.020701
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Effect of different pre-analytical conditions on plasma lactate concentration

Abstract: IntroductionPlasma lactate is a frequently used and important parameter for medical decision making. To setup a pre-analytical algorithm, we aimed to investigate the influence of different test tube additives, aliquoting, ice storage and haemolysis on plasma lactate concentrations for possible sparing critically ill (ICU) patients of additional blood drawing.Materials and methodsIn our study (N = 177), lactate concentration and haemolysis index (HI) were measured in aliquoted (AHP) and unaliquoted (HP) Li-hepa… Show more

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Cited by 5 publications
(4 citation statements)
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“…Rapid recognition of sepsis is of paramount importance, since it allows early treatment and reduces mortality [ 20 ]. Lactate concentrations increase with decreasing tissue perfusion due to anaerobic cellular respiration, making lactate an early warning indicator for directly assessing of shock severity and mortality rates [ 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…Rapid recognition of sepsis is of paramount importance, since it allows early treatment and reduces mortality [ 20 ]. Lactate concentrations increase with decreasing tissue perfusion due to anaerobic cellular respiration, making lactate an early warning indicator for directly assessing of shock severity and mortality rates [ 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…This may delay the results for clinical use, require recollection of patients, increases the cost of personnel time and consumables, and certainly may increase the risk for patient harm. 7 Several studies have examined stability of lactate in whole blood, plasma or serum, with either heparin or fluorinated collection tubes 7,9,10,[12][13][14] ; however, the conditions outlined in these studies failed to fully reflect the delayed timing conditions experienced by some remote/ rural laboratories or nursing stations with pre-analytical constraints (e.g. not having centrifuges for rapid separation of plasma from cells).…”
Section: Discussionmentioning
confidence: 99%
“…Blood collection devices containing lithium heparin or sodium fluoride/ potassium oxalate (NaF/KOx) additives are commonly used and are usually delivered to the laboratory at room temperature or on ice, and are usually centrifuged within 15-30 min from collection. [9][10][11] However, this practice is not standardized, and some laboratories have even extended the allowed turnaround time (TAT) interval to 45 min or 1 h, and some even longer, without having the appropriate evidence to support this practice. Furthermore, many large tertiary care centres are also reference sites, performing referred-in work from remote laboratories or clinical stations that may not have the appropriate pre-analytical equipment or technical oversight to process blood specimens (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Lactate was measured by point-of-care testing (StatStrip Xpress lactate, Nova Biomedical), as lactate cannot be measured reliably from stored blood samples. 18 The venous blood samples were stored at -70⁰C for later measurements of CRP and PCT. All patients received care as usual.…”
Section: Methodsmentioning
confidence: 99%